Formation of Silicon Centered Spirocyclic Compounds: Reaction of N-Heterocyclic Stable Silylene with Benzoylpyridine, Diisopropyl Azodicarboxylate, and 1,2-Diphenylhydrazine

2011 ◽  
Vol 50 (7) ◽  
pp. 3028-3036 ◽  
Author(s):  
Ramachandran Azhakar ◽  
Sankaranarayana Pillai Sarish ◽  
Gašper Tavčar ◽  
Herbert W. Roesky ◽  
Jakob Hey ◽  
...  
Keyword(s):  
Spirocyclic Compounds ◽  
Stable Silylene

Strategies and methodologies for the construction of spiro-fused γ-lactams: an update

2021 ◽  
Author(s):  
Américo José dos Santos Alves ◽  
Nuno Guerreiro Alves Alves ◽  
Maria I.L. Soares ◽  
Teresa M. V. D. Pinho e Melo
Keyword(s):  
Naturally Occurring ◽  
Wide Range ◽  
Spirocyclic Compounds

Spiro-γ-lactams (spiropyrrolinin-2-ones) are a class of spirocyclic compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules. The increasing attention to spirocyclic lactams in drug...

ChemInform Abstract: Stereocontrolled [3 + 2] Annulations with Arene Chromium Tricarbonyl Complexes: Construction of Spirocyclic Compounds Related to Fredericamycin A.

ChemInform ◽  
2010 ◽  
Vol 33 (43) ◽  
pp. no-no
Author(s):  
William H. Moser ◽  
Jian Zhang ◽  
Carl S. Lecher ◽  
Tracy L. Franzier ◽  
Maren Pink
Keyword(s):  
Chromium Tricarbonyl ◽  
Fredericamycin A ◽  
Spirocyclic Compounds ◽  
Chromium Tricarbonyl Complexes ◽  
Arene Chromium Tricarbonyl

The stable silylene Si[(NCH2Bu)2C6H4-1,2]: insertion into LiC or LiSi bonds of lithium alkyls LiR or [Li{Si(SiMe3)3}(THF)3] [R=Me, Bu or CH(SiMe3)2]

2002 ◽  
Vol 651 (1-2) ◽  
pp. 150-156 ◽  
Author(s):  
Xiaoping Cai ◽  
Barbara Gehrhus ◽  
Peter B. Hitchcock ◽  
Michael F. Lappert ◽  
J.Chris Slootweg
Keyword(s):  
Stable Silylene

Two New Spirocyclic Compounds from Gymnotheca involucrata

2018 ◽  
Vol 54 (6) ◽  
pp. 1118-1120
Author(s):  
Ya-Mei Zhang ◽  
Ming-Sheng Su ◽  
Feng Shao ◽  
Ming Yang ◽  
Pu-Zhao Zhang
Keyword(s):  
Spirocyclic Compounds

Highly Regioselective Synthesis of Spirocyclic Compounds by a Palladium-Catalyzed Intermolecular Tandem Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (52) ◽  
Author(s):  
Hai-Peng Bi ◽  
Xue-Yuan Liu ◽  
Fa-Rong Gou ◽  
Li-Na Guo ◽  
Xin-Hua Duan ◽  
...  
Keyword(s):  
Regioselective Synthesis ◽  
Tandem Reaction ◽  
Palladium Catalyzed ◽  
Spirocyclic Compounds

scholarly journals Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Long Li ◽  
Shan Wang ◽  
Pengfei Luo ◽  
Ran Wang ◽  
Zheng Wang ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Functional Groups ◽  
Organic Synthesis ◽  
Enantioselective Synthesis ◽  
Direct Access ◽  
Cycloaddition Reactions ◽  
Drug Discovery And Development ◽  
Spirocyclic Compounds ◽  
And Control ◽  
By Products

AbstractSpirocycles play an important role in drug discovery and development. The direct, catalytic, and enantioselective synthesis of spirocycles from readily available starting materials and in an atom economic manner remains a highly sought-after task in organic synthesis. Herein, an enantioselective Pd-hydride-catalyzed cycloaddition method for the synthesis of spirocyclic compounds directly from two classes of commonly available starting materials, 1,3-enynes and cyclic carbon−hydrogen (C−H) bonds, is reported. The reactions employ a chiral Pd/WingPhos catalyst to both suppress the formation of bis-allenyl by-products and control the stereoselectivity. 1,3-Enynes are used as dielectrophilic four-carbon units in the cycloaddition reactions, which also enables an enyne substrate-directed enantioselectivity switch with good levels of stereocontrol. The present spirocycle synthesis tolerates a broad range of functional groups of 1,3-enyne substrates, including alcohols, esters, nitriles, halides, and olefins. A variety of diverse cyclic nucleophiles, including pharmaceutically important heterocycles and carbocycles, can be flexibly incorporated with spiro scaffolds.

Spirocyclic compounds of the siloxane series

1993 ◽  
Vol 62 (2) ◽  
pp. 193-202 ◽  
Author(s):  
M A Sipyagina ◽  
E E Stepanova ◽  
N M Buzyreva ◽  
T V Vasetchenkova ◽  
Eugeny A Chernyshev
Keyword(s):  
Spirocyclic Compounds

The Thermally Stable Silylene Si[{N(CH2But)}2C6H4-1,2]:  Reactivity toward CO Double Bonds

1997 ◽  
Vol 16 (22) ◽  
pp. 4861-4864 ◽  
Author(s):  
Barbara Gehrhus ◽  
Peter B. Hitchcock ◽  
Michael F. Lappert
Keyword(s):  
Thermally Stable ◽  
Double Bonds ◽  
Stable Silylene

Arylidenemalononitriles as Versatile Synthons in Heterocyclic Synthesis

2022 ◽  
Vol 19 ◽  
Author(s):  
Pannala Padmaja ◽  
Subba Reddy ◽  
Vinod G. Ugale ◽  
Pedavenkatagari Narayana Reddy
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Science ◽  
Heterocyclic Synthesis ◽  
Preparation Methods ◽  
Spirocyclic Compounds ◽  
Novel Complex

Background: Objective: Objective: biological science.: Background: Arylidenemalononitriles are valuable synthons for the construction of a variety of novel complex heterocyclic motifs, fused heterocycle derivatives and spirocyclic compounds. They are versatile chemical intermediates and have increasing applications in industry, agriculture, medicine, Objective: The aim of this review is to highlight the preparation methods and reactions of arylidenemalononitriles in the synthesis of various heterocyclic compounds. Conclusion: n this review, we have presented the application of arylidenemalononitriles to construct a variety of heterocycles. Various catalysts for the preparation of arylidnemalononitriles have been described.

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