Modular design of synthetic protein mimics. Crystal structure of two seven-residue helical peptide segments linked by .epsilon.-aminocaproic acid

1991 ◽  
Vol 113 (10) ◽  
pp. 3952-3956 ◽  
Author(s):  
Isabella L. Karle ◽  
Judith L. Flippen-Anderson ◽  
M. Sukumar ◽  
K. Uma ◽  
P. Balaram
Keyword(s):  
Crystal Structure ◽  
Modular Design ◽  
Aminocaproic Acid ◽  
Protein Mimics ◽  
Synthetic Protein ◽  
Helical Peptide ◽  
Epsilon Aminocaproic Acid ◽  
Peptide Segments

Modular design of synthetic protein mimics. Characterization of the helical conformation of a 13-residue peptide in crystals

Biochemistry ◽  
1989 ◽  
Vol 28 (16) ◽  
pp. 6696-6701 ◽  
Author(s):  
Isabella L. Karle ◽  
Judith L. Flippen-Anderson ◽  
K. Uma ◽  
P. Balaram
Keyword(s):  
Modular Design ◽  
Helical Conformation ◽  
Protein Mimics ◽  
Synthetic Protein

Modular design of synthetic protein mimics. Crystal structures, assembly, and hydration of two 15- and 16-residue apolar, leucyl-rich helical peptides

1990 ◽  
Vol 112 (25) ◽  
pp. 9350-9356 ◽  
Author(s):  
Isabella L. Karle ◽  
Judith L. Flippen-Anderson ◽  
K. Uma ◽  
M. Sukumar ◽  
P. Balaram
Keyword(s):  
Crystal Structures ◽  
Modular Design ◽  
Helical Peptides ◽  
Protein Mimics ◽  
Synthetic Protein

Plasminogen Interactions with Immobilized Fibrinogen

1989 ◽  
Vol 62 (04) ◽  
pp. 1078-1082 ◽  
Author(s):  
Burt Adelman ◽  
Patricia Ouynn
Keyword(s):  
Immunosorbent Assay ◽  
Aminocaproic Acid ◽  
Enzyme Linked Immunosorbent Assay ◽  
Binding Regions ◽  
Dose Dependent Fashion ◽  
Epsilon Aminocaproic Acid ◽  
Dose Dependent

SummaryThis report describes the binding of plasminogen to fibrinogen adsorbed onto polystyrene wells. Binding was determined by enzyme linked immunosorbent assay. Both glu- and lys-plasminogen bound to immobilized fibrinogen in a dose-dependent fashion. However, more lys- than glu-plasminogen bound when equal concentrations of either were added to immobilized fibrinogen. Plasminogen binding was inhibited by epsilon aminocaproic acid indicating that binding was mediated via lysine-binding regions of plasminogen. Soluble fibrinogen added in excess of immobilized fibrinogen did not compete for plasminogen binding but fibrinogen fragments produced by plasmin digestion of fibrinogen did. Treatment of immobilized fibrinogen with thrombin caused a small but significant (p <0.01) increase in plasminogen binding. These studies demonstrate that immobilized fibrinogen binds both glu- and lys-plasminogen and that binding is mediated via lysine-binding regions. These interactions may facilitate plasminogen binding to fibrinogen adsorbed on to surfaces and to cells such as platelets which bind fibrinogen.

Determination of Epsilon Aminocaproic Acid Based on Charge Transfer Complexation with p-Nitrophenlol by Spectrophotometry

2020 ◽  
Vol 16 ◽  
Author(s):  
Sheng-Yun Li ◽  
Fang Tian
Keyword(s):  
Charge Transfer ◽  
Aminocaproic Acid ◽  
Concentration Limit ◽  
Official Method ◽  
Good Precision ◽  
Pharmaceutical Dosage Forms ◽  
Relative Standard ◽  
A Charge ◽  
Epsilon Aminocaproic Acid

: A spectrophotometry was investigated for the determination of epsilon aminocaproic acid (EACA) with p-nitrophenol (PNP). The method was based on a charge transfer (CT) complexation of this drug as n-electron donor with π-acceptor PNP. Experiment indicated that the CT complexation was carried out at room temperature for 10 minutes in dimethyl sulfoxide solvent. The spectrum obtained for EACA/PNP system showed the maximum absorption band at wavelength of 425 nm. The stoichiometry of the CT complex was found to be 1:1 ratio by Job’s method between the donor and the acceptor. Different variables affecting the complexation were carefully studied and optimized. At the optimum reaction conditions, Beer’s law was obeyed in a concentration limit of 1～6 µg mL-1. The relative standard deviation was less than 2.9%. The apparent molar absoptivity was determined to be 1.86×104 L mol-1cm-1 at 425 nm. The CT complexation was also confirmed by both FTIR and 1H NMR measurements. The thermodynamic properties and reaction mechanism of the CT complexation have been discussed. The developed method could be applied successfully for the determination of the studied compound in its pharmaceutical dosage forms with a good precision and accuracy compared to official method as revealed by t- and F-tests.

Pathological fibrinolytic states and their treatment with epsilon aminocaproic acid (EACA)

1966 ◽  
Vol 53 (1) ◽  
pp. 26-29 ◽  
Author(s):  
G. P. McNicol ◽  
M. K. Browne ◽  
Carolyn Bayley ◽  
A. S. Douglas
Keyword(s):  
Aminocaproic Acid ◽  
Epsilon Aminocaproic Acid

Blood loss and transfusion requirements with epsilon-aminocaproic acid use during cranial vault reconstruction surgery

2017 ◽  
Vol 36 ◽  
pp. 153-157 ◽  
Author(s):  
Mark E. Thompson ◽  
Charles Saadeh ◽  
Phillip Watkins ◽  
Laszlo Nagy ◽  
Joshua Demke
Keyword(s):  
Blood Loss ◽  
Aminocaproic Acid ◽  
Cranial Vault ◽  
Reconstruction Surgery ◽  
Transfusion Requirements ◽  
Epsilon Aminocaproic Acid

Could We Know epsilon-Aminocaproic Acid Level During Cardiopulmonary Bypass?

1998 ◽  
Vol 86 (3) ◽  
pp. 680-681
Author(s):  
Elliott Bennett-Guerrero ◽  
Michael G. Mythen
Keyword(s):  
Cardiopulmonary Bypass ◽  
Acid Level ◽  
Aminocaproic Acid ◽  
Epsilon Aminocaproic Acid

Epsilon-Aminocaproic Acid for Synovectomy in Haemophilic Patients

1972 ◽  
Vol 47 (3) ◽  
pp. 146-156 ◽  
Author(s):  
E. Storti ◽  
E. Ascari ◽  
R. Turpini ◽  
E. Molinari ◽  
G. Gamba ◽  
...  
Keyword(s):  
Aminocaproic Acid ◽  
Epsilon Aminocaproic Acid

scholarly journals Management of Idiopathic Thrombocytopenic Purpura in Adult: A Review Article

2012 ◽  
Vol 2 (1) ◽  
pp. 24-28
Author(s):  
Mohammad Ferdous Ur Rahaman ◽  
Farzana Rahman ◽  
Mohammad Salman ◽  
Md. Abdul Kader ◽  
Md. Abdul Kalam Azad
Keyword(s):  
Clinical Presentation ◽  
Protein A ◽  
Spontaneous Remission ◽  
Aminocaproic Acid ◽  
Review Article ◽  
Bleeding Complications ◽  
Medical College ◽  
Chronic Disorder ◽  
Insidious Onset ◽  
Epsilon Aminocaproic Acid

Idiopathic thrombocytopenic purpiira (ITP), also known as primary immune or autoimmune thmmbocytopenic purpura, is a common cause of thrombocytopenia and bleeding complications in children and adults. It mav be confused with other causes of thrombocvtopenia and is treated with agents that varv in efjicacv, toxicity, and cost. Clinical presentation very in children and adult. In children, ITP is usually an acute, self-limited disorder that resolves spontaneously: in adults, it is typically a chronic disorder with a more insidious onset. In about one third of adults with ITP, the condition is persistent and relatively resistant to most treatments .Available evidence suggests that only about 5% of adults with chronic ITP have spontaneous remission. The principal therapeutic options for ITP include glucocorticoids, intravenous immunoglobulin and splenectomy. Other treatments have been used for refractory cases; these include intravenous anti-Rh (D), azathioprine, cyclophosphamide, danazol, vinca alkaloids, ascorbic acid, colchicine, interferon-alpha, combination chemotherapy, protein A, immunoadsorption, cyclosporine, epsilon-aminocaproic acid, plasma exchange, and accessory splenectomy. Journal of Shaheed Suhrawardy Medical College Vol 2No.1 June 2010 page 24-28 DOI: http://dx.doi.org/10.3329/jssmc.v2i1.12348

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