Structural studies of viruses by laser Raman spectroscopy. Part XXXVI. Cysteine conformation and sulfhydryl interactions in proteins and viruses. 2. Normal coordinate analysis of the cysteine side chain in model compounds

1992 ◽  
Vol 114 (19) ◽  
pp. 7463-7469 ◽  
Author(s):  
Huimin Li ◽  
Charles J. Wurrey ◽  
George J. Thomas
Biochemistry ◽  
1990 ◽  
Vol 29 (21) ◽  
pp. 5018-5026 ◽  
Author(s):  
Tiansheng Li ◽  
Zhongguo Chen ◽  
John E. Johnson ◽  
George J. Thomas

2006 ◽  
Vol 20 (5-6) ◽  
pp. 269-273 ◽  
Author(s):  
J. H. Zhou ◽  
X. H. Wu ◽  
S. H. Wei ◽  
X. T. Gu ◽  
Y. Y. Feng ◽  
...  

Laser Raman spectroscopy was used to detect the nature of the structural change in lysozyme sensitized by hypocrellin A (HA) at the molecular level. The results indicated that the orderly structure of lysozyme has been damaged by the active oxygen (1O2, O2−·and.OH, etc.) generated by HA, and cause the changes in H-bonds system of the main chain and the side chain of lysozyme.


Biochemistry ◽  
1982 ◽  
Vol 21 (16) ◽  
pp. 3866-3878 ◽  
Author(s):  
George J. Thomas ◽  
Yinglin Li ◽  
Margaret T. Fuller ◽  
Jonathan King

1976 ◽  
Vol 30 (5) ◽  
pp. 483-494 ◽  
Author(s):  
George J. Thomas

A survey is given of developments leading to the application of laser-Raman spectroscopy in structural studies of viruses and model nucleoproteins. The major constituents of viruses — nucleic acid and protein molecules — exhibit Raman spectra which differ greatly from one another, both in the spectral ranges that contain vibrational frequencies of conformational interest and in the relative intensities of Raman scattering of their respective subgroups. These features, not common to the infrared spectra, allow laser-Raman spectroscopy to be exploited for the study of viral assembly and nucleoprotein interactions. Examples considered here are the RNA-containing virus MS2, the DNA-containing viruses Pfl and fd, and the complex of polylysine with DNA.


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