Structural studies of P22 phage, precursor particles, and proteins by laser Raman spectroscopy

Biochemistry ◽  
1982 ◽  
Vol 21 (16) ◽  
pp. 3866-3878 ◽  
Author(s):  
George J. Thomas ◽  
Yinglin Li ◽  
Margaret T. Fuller ◽  
Jonathan King
Keyword(s):  
Raman Spectroscopy ◽  
Laser Raman Spectroscopy ◽  
Structural Studies ◽  
Laser Raman

Structural studies of bean pod mottle virus, capsid and RNA in crystal and solution states by laser Raman spectroscopy

Biochemistry ◽  
1990 ◽  
Vol 29 (21) ◽  
pp. 5018-5026 ◽  
Author(s):  
Tiansheng Li ◽  
Zhongguo Chen ◽  
John E. Johnson ◽  
George J. Thomas
Keyword(s):  
Raman Spectroscopy ◽  
Laser Raman Spectroscopy ◽  
Mottle Virus ◽  
Structural Studies ◽  
Virus Capsid ◽  
Bean Pod Mottle Virus ◽  
Laser Raman

Raman Spectroscopy and Virus Research

1976 ◽  
Vol 30 (5) ◽  
pp. 483-494 ◽  
Author(s):  
George J. Thomas
Keyword(s):  
Raman Spectroscopy ◽  
Nucleic Acid ◽  
Infrared Spectra ◽  
Viral Assembly ◽  
Laser Raman Spectroscopy ◽  
Structural Studies ◽  
Laser Raman ◽  
Protein Molecules ◽  
Virus Research ◽  
Spectral Ranges

A survey is given of developments leading to the application of laser-Raman spectroscopy in structural studies of viruses and model nucleoproteins. The major constituents of viruses — nucleic acid and protein molecules — exhibit Raman spectra which differ greatly from one another, both in the spectral ranges that contain vibrational frequencies of conformational interest and in the relative intensities of Raman scattering of their respective subgroups. These features, not common to the infrared spectra, allow laser-Raman spectroscopy to be exploited for the study of viral assembly and nucleoprotein interactions. Examples considered here are the RNA-containing virus MS2, the DNA-containing viruses Pfl and fd, and the complex of polylysine with DNA.

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