Synthesis and chiroptical properties of .gamma.-substituted rigid and conformationally flexible systems having 1,3-diene and .alpha.,.beta.-unsaturated carbonyl chromophores. The planar diene rule

The mechanical properties of three titanium alloys (Ti-7Mo-3Al, Ti-7Mo- 3Cu and Ti-7Mo-3Ta) were evaluated as function of: 1) Solutionizing in the beta field and aging, 2) Thermal Mechanical Processing in the beta field and aging, 3) Solutionizing in the alpha + beta field and aging. The samples were isothermally aged in the temperature range 300° to 700*C for 4 to 24 hours, followed by a water quench. Transmission electron microscopy and X-ray method were used to identify the phase formed. All three alloys solutionized at 1050°C (beta field) transformed to martensitic alpha (alpha prime) upon being water quenched. Despite this heavily strained alpha prime, which is characterized by microtwins the tensile strength of the as-quenched alloys is relatively low and the elongation is as high as 30%.

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Practical Resources for Provision of Services to Culturally and Linguistically Diverse Users of AAC

Perspectives on Communication Disorders and Sciences in Culturally and Linguistically Diverse Populations ◽

10.1044/cds22.1.25 ◽

2015 ◽

Vol 22 (1) ◽

pp. 25-39

Author(s):

Elena Dukhovny ◽

E. Betsy Kelly

Keyword(s):

Best Practices ◽

Augmentative And Alternative Communication ◽

Linguistically Diverse ◽

Intervention Strategies ◽

Culturally And Linguistically Diverse ◽

Limited Resources ◽

Flexible Systems ◽

Alternative Communication ◽

Practical Applications ◽

Provision Of Services

According to the 2010 U.S. Census, over 20% of Americans speak a language other than English in the home, with Spanish, Chinese, and French being the languages most commonly spoken, aside from English. However, few augmentative and alternative communication (AAC) systems offer multilingual support for individuals with limited functional speech. There has been much discussion in the AAC community about best practices in AAC system design and intervention strategies, but limited resources exist to help us provide robust, flexible systems for users who speak languages other than English. We must provide services that take into consideration the unique needs of culturally and linguistically diverse users of AAC and help them reach their full communication potential. This article outlines basic guidelines for best practices in AAC design and selection, and presents practical applications of these best practices to multilingual/multicultural clients.

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Bioavailability of naringenin chalcone in humans after ingestion of cherry tomatoes

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000574 ◽

2020 ◽

Vol 90 (5-6) ◽

pp. 411-416 ◽

Cited By ~ 2

Author(s):

Carina Kolot ◽

Ana Rodriguez-Mateos ◽

Rodrigo Feliciano ◽

Katharina Bottermann ◽

Wilhelm Stahl

Keyword(s):

Plasma Levels ◽

Average Concentration ◽

Biologically Active ◽

Thiol Groups ◽

Structural Element ◽

Active Molecule ◽

Reactive Center ◽

Average Maximum ◽

Alpha Beta ◽

Cherry Tomatoes

Abstract. Chalcones are a type of flavonoids characterized by an α-β unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system. Naringenin chalcone is abundant in the diet but little is known about its bioavailability. In this work, the bioavailability of naringenin chalcone from tomatoes was investigated in a group of healthy men (n=10). After ingestion of 600 grams of tomatoes providing a single dose of 17.3 mg naringenin chalcone, 0.2 mg of naringenin, and 195 mg naringin plasma levels of free and conjugated naringenin and naringenin chalcone (glucuronide and sulfate) were analyzed by UHPLC-QTOF-MS at 0.5, 1, 3, and 6 h post-consumption. Plasma levels of conjugated naringenin increased to about 12 nmol/L with a maximum at about 3 h. Concentrations of free naringenin hardly elevated above baseline. Plasma levels of free and conjugated naringenin chalcone significantly increased. A maximum of the conjugated chalcone was reached at about 3 h after ingestion with an average concentration of about 0.5 nmol/L. No free chalcone was detectable at baseline but low amounts of the unconjugated compound could be detected with an average maximum of 0.8 nmol/L at about 1 h after ingestion. The data demonstrate that naringenin chalcone is bioavailable in humans from cherry tomatoes as a dietary source. However, availability is poor and intramolecular cyclisation as well as extended metabolism likely contribute to the inactivation of the reactive alpha-beta unsaturated reactive center as well as the excretion of the biologically active molecule, respectively.

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