Glucose Binding Isotope Effects in the Ternary Complex of Brain Hexokinase Demonstrate Partial Relief of Ground-State Destabilization

2003 ◽  
Vol 125 (16) ◽  
pp. 4672-4673 ◽  
Author(s):  
Brett E. Lewis ◽  
Vern L. Schramm
Keyword(s):  
Ground State ◽  
Ternary Complex ◽  
Isotope Effects ◽  
Partial Relief ◽  
Glucose Binding

Isotope effects in nucleophilic substitution reactions. V. The mechanism of the decomposition of 1-phenylethyldimethylphenylammonium halides in chloroform

1986 ◽  
Vol 64 (6) ◽  
pp. 1206-1214 ◽  
Author(s):  
Helen Alma Joly ◽  
Kenneth Charles Westaway
Keyword(s):  
Ground State ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Steric Effects ◽  
Halide Ions ◽  
Substitution Reactions ◽  
Kinetic Isotope ◽  
Hydrogen Deuterium ◽  
Primary Substrate ◽  
Triple Ion

Secondary α and β hydrogen–deuterium kinetic isotope effects have been used together to show that the SN reaction between 1-phenylethyldimethylphenylammonium ion and bromide or iodide ion in chloroform occurs by way of an SN2 mechanism within a triple ion in spite of the fact that it reacts faster than the primary substrate, benzyldimethylphenylammonium bromide. The very loose transition state and steric effects in the ground state appear to be responsible for the unusually fast SN2 reactions between 1-phenylethyldimethylphenylammonium ion and halide ions in chloroform.

Imaging the isotope effects in the ground state reaction of Cl CH4 and CD4

2005 ◽  
Vol 103 (13) ◽  
pp. 1757-1763 ◽  
Author(s):  
J. Zhou ◽  
B. Zhang ◽  
J. J. Lin ◽  
K. Liu
Keyword(s):  
Ground State ◽  
Isotope Effects

Deuterium Isotope Effects on Reaction Rates of Ground State Zr with Ethylene and Propylene

2000 ◽  
Vol 104 (7) ◽  
pp. 1524-1531 ◽  
Author(s):  
Meredith Porembski ◽  
James C. Weisshaar
Keyword(s):  
Ground State ◽  
Isotope Effects ◽  
Reaction Rates ◽  
Deuterium Isotope Effects

scholarly journals Mechanistic origin of the sigmoidal rate behaviour of glucokinase

1986 ◽  
Vol 233 (2) ◽  
pp. 347-350 ◽  
Author(s):  
G Pettersson
Keyword(s):  
Ternary Complex ◽  
Flow Characteristics ◽  
Free Enzyme ◽  
Kinetic Properties ◽  
Complex Mechanism ◽  
Insufficient Evidence ◽  
Conformational States ◽  
Model Studies ◽  
Glucose Binding ◽  
Rate Behaviour

Model studies are presented which demonstrate that reactions proceeding by a random ternary-complex mechanism may exhibit most pronounced deviations from Michaelis-Menten kinetics even if the reaction is effectively ordered with respect to net reaction flow. In particular, the kinetic properties and reaction flow characteristics of glucokinase can be accounted for in such terms. It is concluded that insufficient evidence has been presented to support the idea that glucokinase operates by a ‘mnemonical’ type of mechanism involving glucose binding to distinct conformational states of free enzyme. The sigmoidal rate behaviour of glucokinase can presently be more simply explained in terms of glucose binding to differently ligated states of the enzyme.

ChemInform Abstract: IDENTIFICATION BY MEANS OF HEAVY-ATOM ISOTOPE EFFECTS OF A PHOTOACTIVATED REACTION AS A GROUND-STATE PROCESS

1979 ◽  
Vol 10 (1) ◽  
Author(s):  
H. KWART ◽  
D. A. BENKO ◽  
J. STREITH ◽  
J. L. SCHUPPISER
Keyword(s):  
Ground State ◽  
Isotope Effects ◽  
Heavy Atom ◽  
State Process

A Search for Isotope Effects in Chemiluminescent Reactions of Metastable Ca*( 3Pj, 1D2 ) Atoms with CH3I and CD3I Molecules

1999 ◽  
Vol 54 (3-4) ◽  
pp. 191-194 ◽  
Author(s):  
B. Pranszke ◽  
P. Kierzkowski ◽  
A. Kowalski
Keyword(s):  
Cross Sections ◽  
Ground State ◽  
Isotope Effects ◽  
Reaction Cross ◽  
Isotopic Substitution ◽  
Methyl Group ◽  
Total Collision ◽  
Reaction Cross Sections

Chemiluminescent reactions of calcium atoms in the metastable 3Pj and 1D2 states with CH3I and CD3I were studied in a beam-gas arrangement. Calcium monoiodide spectra associated with transitions from the electronic A 2Π, B 2Σ+ and C 2Π states to the X 2Σ+ ground state were recorded. Total collision and chemiluminescence cross sections were measured. It was found that isotopic substitution in the methyl group does not change the reaction cross sections and the chemiluminescence spectra.

Identification by means of heavy-atom isotope effects of a photoactivated reaction as a ground-state process

1978 ◽  
Vol 100 (20) ◽  
pp. 6502-6504 ◽  
Author(s):  
H. Kwart ◽  
D. A. Benko ◽  
J. Streith ◽  
J. L. Schuppiser
Keyword(s):  
Ground State ◽  
Isotope Effects ◽  
Heavy Atom ◽  
State Process
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