Transition State Analysis of Thymidine Hydrolysis by Human Thymidine Phosphorylase

Phillip A. Schwartz; Mathew J. Vetticatt; Vern L. Schramm

doi:10.1021/ja105041j

Transition State Analysis of Thymidine Hydrolysis by Human Thymidine Phosphorylase

Journal of the American Chemical Society ◽

10.1021/ja105041j ◽

2010 ◽

Vol 132 (38) ◽

pp. 13425-13433 ◽

Cited By ~ 18

Author(s):

Phillip A. Schwartz ◽

Mathew J. Vetticatt ◽

Vern L. Schramm

Keyword(s):

Transition State ◽

Thymidine Phosphorylase ◽

State Analysis

Transition State Analysis of the Arsenolytic Depyrimidination of Thymidine by Human Thymidine Phosphorylase

Biochemistry ◽

10.1021/bi101900b ◽

2011 ◽

Vol 50 (8) ◽

pp. 1412-1420 ◽

Cited By ~ 19

Author(s):

Phillip A. Schwartz ◽

Mathew J. Vetticatt ◽

Vern L. Schramm

Keyword(s):

Transition State ◽

Thymidine Phosphorylase ◽

State Analysis

Kinetic investigation of hydroxide ion attack at high spin Fe(II) bromosalicylidine chelates with amino acids in binary aqueous solvents: Initial and transition state analysis

Russian Journal of General Chemistry ◽

10.1134/s1070363213120499 ◽

2013 ◽

Vol 83 (12) ◽

pp. 2510-2518 ◽

Cited By ~ 5

Author(s):

Laila H. Abdel-Rahman ◽

Rafat M. El-Khatib ◽

Lobna A. E. Nassr ◽

Ahmed M. Abu-Dief

Keyword(s):

Amino Acids ◽

Transition State ◽

High Spin ◽

Kinetic Investigation ◽

Hydroxide Ion ◽

State Analysis

Transient [3,3] Cope rearrangement of 3,3-dicyano-1,5-dienes: computational analysis and 2-step synthesis of arylcycloheptanes

Chemical Science ◽

10.1039/c8sc03057j ◽

2018 ◽

Vol 9 (46) ◽

pp. 8760-8764 ◽

Cited By ~ 8

Author(s):

Ehsan Fereyduni ◽

Jacob N. Sanders ◽

Gabriel Gonzalez ◽

K. N. Houk ◽

Alexander J. Grenning

Keyword(s):

Transition State ◽

Computational Analysis ◽

Cope Rearrangement ◽

State Analysis

Unexpectedly mild [3,3] rearrangement computed transition state analysis, regio- and diastereoselecitve transformations multicomponent couplings, convergent 2-step arylcycloheptene synthesis.

Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-enzymatic Glycoside Hydrolysis and Transfer

Advances in Physical Organic Chemistry ◽

10.1016/s0065-3160(02)37004-7 ◽

2002 ◽

pp. 239-314 ◽

Cited By ~ 34

Author(s):

Paul J. Berti ◽

Kelly S.E. Tanaka

Keyword(s):

Transition State ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Glycoside Hydrolysis ◽

State Analysis

Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction

Biochemistry ◽

10.1021/bi00211a033 ◽

1993 ◽

Vol 32 (48) ◽

pp. 13212-13219 ◽

Cited By ~ 112

Author(s):

Paul C. Kline ◽

Vern L. Schramm

Keyword(s):

Transition State ◽

Purine Nucleoside Phosphorylase ◽

Catalytic Mechanism ◽

Purine Nucleoside ◽

Nucleoside Phosphorylase ◽

State Analysis

[13] Enzymatic transition-state analysis and transition-state analogs

Methods in Enzymology - Enzyme kinetics and mechanism Part E: Energetics of Enzyme Catalysis ◽

10.1016/s0076-6879(99)08015-5 ◽

1999 ◽

pp. 301-355 ◽

Cited By ~ 53

Author(s):

Vern L. Schramm

Keyword(s):

Transition State ◽

Transition State Analogs ◽

State Analysis

Transition-state analysis of nucleoside hydrolase from Crithidia fasciculata

Biochemistry ◽

10.1021/bi00108a026 ◽

1991 ◽

Vol 30 (44) ◽

pp. 10788-10795 ◽

Cited By ~ 83

Author(s):

Benjamin A. Horenstein ◽

David W. Parkin ◽

Bernardo Estupinan ◽

Vern L. Schramm

Keyword(s):

Transition State ◽

Crithidia Fasciculata ◽

Nucleoside Hydrolase ◽

State Analysis

Hydrophobicity, reactivity trends of base catalyzed hydrolysis of some novel high spin Fe(II) Schiff base amino acid chelates in some binary aqueous solvent mixtures: Initial-transition state analysis

Journal of Saudi Chemical Society ◽

10.1016/j.jscs.2013.11.004 ◽

2017 ◽

Vol 21 ◽

pp. S128-S135 ◽

Cited By ~ 1

Author(s):

Laila H. Abdel-Rahman ◽

Rafat M. El-Khatib ◽

Lobna A.E. Nassr ◽

Ahmed M. Abu-Dief

Keyword(s):

Schiff Base ◽

Amino Acid ◽

Transition State ◽

High Spin ◽

Solvent Mixtures ◽

Aqueous Solvent Mixtures ◽

Aqueous Solvent ◽

Hydrolysis Of ◽

State Analysis

Uncovering pathways in DNA oligonucleotide hybridization via transition state analysis

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0904721106 ◽

2009 ◽

Vol 106 (43) ◽

pp. 18125-18130 ◽

Cited By ~ 36

Author(s):

E. J. Sambriski ◽

D. C. Schwartz ◽

J. J. de Pablo

Keyword(s):

Transition State ◽

Oligonucleotide Hybridization ◽

State Analysis

The Synthesis of N-Ribosyl Transferase Inhibitors Based on a Transition State Blueprint

Australian Journal of Chemistry ◽

10.1071/ch04112 ◽

2004 ◽

Vol 57 (9) ◽

pp. 837 ◽

Cited By ~ 7

Author(s):

Gary B. Evans

Keyword(s):

Transition State ◽

Enzyme Inhibitors ◽

Processing Enzymes ◽

Design And Synthesis ◽

Therapeutic Uses ◽

Transition State Analogue ◽

Transition State Analogue Inhibitors ◽

State Analysis

A quarter of a century ago transition state analysis and transition state analogue design promised the prospect of extraordinarily potent enzyme inhibitors. The present overview describes the transition state analysis of a variety of N-ribosyl transferases, the design and synthesis of extremely powerful transition state analogue inhibitors of these nucleoside processing enzymes, and their current therapeutic uses and potentials.