Syntheses of Water-Soluble Octahedral, Truncated Octahedral, and Cubic Pt–Ni Nanocrystals and Their Structure–Activity Study in Model Hydrogenation Reactions

2012 ◽  
Vol 134 (21) ◽  
pp. 8975-8981 ◽  
Author(s):  
Yuen Wu ◽  
Shuangfei Cai ◽  
Dingsheng Wang ◽  
Wei He ◽  
Yadong Li
Keyword(s):  
Water Soluble ◽  
Structure Activity ◽  
Hydrogenation Reactions

Catalytically active, magnetically separable, and water-soluble FePt nanoparticles modified with cyclodextrin for aqueous hydrogenation reactions

2009 ◽  
Vol 11 (9) ◽  
pp. 1337 ◽  
Author(s):  
Kohsuke Mori ◽  
Naoki Yoshioka ◽  
Yuichi Kondo ◽  
Tetsuya Takeuchi ◽  
Hiromi Yamashita
Keyword(s):  
Water Soluble ◽  
Fept Nanoparticles ◽  
Catalytically Active ◽  
Hydrogenation Reactions ◽  
Magnetically Separable

A structure-activity study of seven new water soluble nitrosoureas

1979 ◽  
Vol 28 (8) ◽  
pp. 1301-1306 ◽  
Author(s):  
Joanna M. Heal ◽  
Patricia Fox ◽  
Philip S. Schein
Keyword(s):  
Water Soluble ◽  
Structure Activity

scholarly journals Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

2020 ◽  
Author(s):  
Alexander L. Nielsen ◽  
Nima Rajabi ◽  
Norio Kudo ◽  
Kathrine Lundø ◽  
Carlos Moreno-Yruela ◽  
...  
Keyword(s):  
Drug Target ◽  
Water Soluble ◽  
Target Engagement ◽  
X Ray ◽  
Tubulin Acetylation ◽  
Structure Activity ◽  
Complex Functions ◽  
Lysine Residues ◽  
Chain Acyl ◽  
Single Compound

ABSTRACTSirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and cancer. Therefore, access to well-characterized and robust tool compounds is essential for the continued investigation of the complex functions of this enzyme. Here, we report a collection of probes that are potent, selective, stable in serum, water-soluble, amenable to cell culture experiments, and inhibit both SIRT2 deacetylation and demyristoylation. Compared to the current landscape of SIRT2 inhibitors, this is a unique ensemble of features built into a single compound. We expect the developed chemotypes to find broad application in the interrogation of SIRT2 functions in both healthy and diseased cells, and to provide a foundation for the development of future therapeutics.

scholarly journals Water soluble polymer–surfactant complexes-stabilized Pd(0) nanocatalysts: Characterization and structure–activity relationships in biphasic hydrogenation of alkenes and α,β-unsaturated ketones

2016 ◽  
Vol 340 ◽  
pp. 144-153 ◽  
Author(s):  
Brunno L. Albuquerque ◽  
Audrey Denicourt-Nowicki ◽  
Cristelle Mériadec ◽  
Josiel B. Domingos ◽  
Alain Roucoux
Keyword(s):  
Water Soluble ◽  
Soluble Polymer ◽  
Water Soluble Polymer ◽  
Unsaturated Ketones ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Polymer Surfactant

Water-soluble small-molecule probes for RNA based on a two-photon fluorescence “off–on” process: systematic analysis in live cell imaging and understanding of structure–activity relationships

2017 ◽  
Vol 53 (99) ◽  
pp. 13245-13248 ◽  
Author(s):  
Hong Li ◽  
Yuncang Li ◽  
Huihui Zhang ◽  
Guoyong Xu ◽  
Yuliang Zhang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Systematic Analysis ◽  
Pyridinium Cation ◽  
Two Photon ◽  
Small Molecule Probes ◽  
Structure Activity ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

The remarkable two-photon fluorescence responses in vitro and in vivo of L1–5 for RNA revealed the synergistic effect of the amino group and the pyridinium cation.

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