scholarly journals The Transcriptional Complex Between theBCL2i-Motif and hnRNP LL Is a Molecular Switch for Control of Gene Expression That Can Be Modulated by Small Molecules

2014 ◽  
Vol 136 (11) ◽  
pp. 4172-4185 ◽  
Author(s):  
Hyun-Jin Kang ◽  
Samantha Kendrick ◽  
Sidney M. Hecht ◽  
Laurence H. Hurley
Keyword(s):  
Gene Expression ◽  
Small Molecules ◽  
Molecular Switch ◽  
Control Of Gene Expression ◽  
Transcriptional Complex

scholarly journals Control of Gene Expression with Small Molecules

2003 ◽  
Vol 10 (12) ◽  
pp. 1245-1253 ◽  
Author(s):  
Sonalee Athavankar ◽  
Blake R Peterson
Keyword(s):  
Gene Expression ◽  
Small Molecules ◽  
Control Of Gene Expression

Syntheses of Functionalized Biotin N-1‘ Derivatives:  New Tools for the Control of Gene Expression with Small Molecules

2006 ◽  
Vol 17 (4) ◽  
pp. 1030-1035 ◽  
Author(s):  
Cyril Inard ◽  
Emmanuelle Fourcade ◽  
Rudi Baron ◽  
Daniel Tovar ◽  
Laurent Chaisemartin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Small Molecules ◽  
Control Of Gene Expression

scholarly journals A tunable dual-input system for ‘on-demand’ dynamic gene expression regulation

2018 ◽  
Author(s):  
Elisa Pedone ◽  
Dan L. Rocca ◽  
Lorena Postiglione ◽  
Francesco Aulicino ◽  
Sandra Montes-Olivas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Protein Stability ◽  
Small Molecules ◽  
Cellular Systems ◽  
Signalling Pathway ◽  
Control Of Gene Expression ◽  
Protein Levels ◽  
Cell Functions ◽  
Input System

AbstractCellular systems have evolved numerous mechanisms to finely control signalling pathway activation and properly respond to changing environmental stimuli. This is underpinned by dynamic spatiotemporal patterns of gene expression. Indeed, in addition to gene transcription and translation regulation, modulation of protein levels, dynamics and localization are also essential checkpoints that govern cell functions. The introduction of tetracycline-inducible promoters has allowed gene expression control using orthogonal small molecules, facilitating rapid and reversible manipulation to study gene function in biological systems. However, differing protein stabilities means this solely transcriptional regulation is insufficient to allow precise ON-OFF dynamics, thus hindering generation of temporal profiles of protein levels seen in vivo. We developed an improved Tet-On based system augmented with conditional destabilising elements at the post-translational level that permits simultaneous control of gene expression and protein stability. Integrating these properties to control expression of a fluorescent protein in mouse Embryonic Stem Cells (mESCs), we found that adding protein stability control allows faster response times to changes in small molecules, fully tunable and enhanced dynamic range, and vastly improved microfluidic-based in-silico feedback control of gene expression. Finally, we highlight the effectiveness of our dual-input system to finely modulate levels of signalling pathway components in stem cells.

A Review on Important Histone Acetyltransferase (HAT) Enzymes as Targets for Cancer Therapy

2019 ◽  
Vol 15 (2) ◽  
pp. 120-130
Author(s):  
Mohammad Ghanbari ◽  
Reza Safaralizadeh ◽  
Kiyanoush Mohammadi
Keyword(s):  
Gene Expression ◽  
Histone Acetyltransferase ◽  
Critical Role ◽  
Cancer Treatments ◽  
Control Of Gene Expression ◽  
Post Translational Modifications ◽  
Therapeutic Drugs ◽  
The Status ◽  
Acetyl Group ◽  
Increase Gene Expression

At the present time, cancer is one of the most lethal diseases worldwide. There are various factors involved in the development of cancer, including genetic factors, lifestyle, nutrition, and so on. Recent studies have shown that epigenetic factors have a critical role in the initiation and development of tumors. The histone post-translational modifications (PTMs) such as acetylation, methylation, phosphorylation, and other PTMs are important mechanisms that regulate the status of chromatin structure and this regulation leads to the control of gene expression. The histone acetylation is conducted by histone acetyltransferase enzymes (HATs), which are involved in transferring an acetyl group to conserved lysine amino acids of histones and consequently increase gene expression. On the basis of similarity in catalytic domains of HATs, these enzymes are divided into different groups such as families of GNAT, MYST, P300/CBP, SRC/P160, and so on. These enzymes have effective roles in apoptosis, signaling pathways, metastasis, cell cycle, DNA repair and other related mechanisms deregulated in cancer. Abnormal activation of HATs leads to uncontrolled amplification of cells and incidence of malignancy signs. This indicates that HAT might be an important target for effective cancer treatments, and hence there would be a need for further studies and designing of therapeutic drugs on this basis. In this study, we have reviewed the important roles of HATs in different human malignancies.

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