8-Methoxydeoxyguanosine as an Effective Precursor of 2-Aminoimidazolone, a Major Guanine Oxidation Product in One-Electron Oxidation of DNA

1999 ◽  
Vol 121 (46) ◽  
pp. 10836-10837 ◽  
Author(s):  
Hisafumi Ikeda ◽  
Isao Saito
Keyword(s):  
Oxidation Product ◽  
Guanine Oxidation ◽  
Oxidation Of Dna

Electrodeposition of guanine oxidation product onto zinc oxide nanoparticles: Application to nanomolar detection of l-cysteine

2009 ◽  
Vol 135 (2) ◽  
pp. 632-641 ◽  
Author(s):  
Rahman Hallaj ◽  
Abdollah Salimi ◽  
Keivan Akhtari ◽  
Saied Soltanian ◽  
Hussein Mamkhezri
Keyword(s):  
Zinc Oxide ◽  
Oxidation Product ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Guanine Oxidation ◽  
Nanomolar Detection

Product Analysis of GG-Specific Photooxidation of DNA via Electron Transfer:  2-Aminoimidazolone as a Major Guanine Oxidation Product

1998 ◽  
Vol 120 (29) ◽  
pp. 7373-7374 ◽  
Author(s):  
Katsuhito Kino ◽  
Isao Saito ◽  
Hiroshi Sugiyama
Keyword(s):  
Electron Transfer ◽  
Oxidation Product ◽  
Product Analysis ◽  
Guanine Oxidation

scholarly journals Possible cause of G·C→C·G transversion mutation by guanine oxidation product, imidazolone

2001 ◽  
Vol 8 (4) ◽  
pp. 369-378 ◽  
Author(s):  
Katsuhito Kino ◽  
Hiroshi Sugiyama
Keyword(s):  
Oxidation Product ◽  
Guanine Oxidation ◽  
Transversion Mutation ◽  
Possible Cause

Oxidation mechanism of carcinogenic bis-azo dyestuff Trypan Blue

1982 ◽  
Vol 47 (10) ◽  
pp. 2746-2748 ◽  
Author(s):  
Miroslav Matrka ◽  
Jana Pípalová
Keyword(s):  
Acid Medium ◽  
Quantitative Evaluation ◽  
Oxidation Product ◽  
Trypan Blue ◽  
Oxidation Mechanism ◽  
Azo Coupling ◽  
Arenediazonium Salt

Oxidation of Trypan Blue with cerium(IV) ion in acid medium gives arenediazonium cation similar to the oxidation product of N,N-dimethyl-4-aminoazobenzene. Quantitative evaluation of the arenediazonium salt formed has been carried out spectrophotometrically after previous C-azo coupling with 2-naphthol.

Oxidation scheme of symmetrically disulphonated naphthidines with cerium(IV) sulphate

1981 ◽  
Vol 46 (3) ◽  
pp. 561-572 ◽  
Author(s):  
Karel Komers
Keyword(s):  
Sulphuric Acid ◽  
Rate Constants ◽  
Oxidation Product ◽  
Side Reaction ◽  
Reaction Scheme ◽  
Second Order ◽  
Intermediate Products ◽  
Stable Intermediate ◽  
Starting Compound ◽  
Oxidation Agent

The author derived theoretical dependences of preasymptotic slopes of the currentless E-t curves (potential of an indicator redox electrode against time) on the number of equivalents, n, of added oxidation agent, assuming a reaction scheme of two consecutive concurrent second-order reactions involving the formation of intermediate products ( a side reaction of the starting compound with the final oxidation product leading to an adduct, which undergoes consecutive bimolecular oxidations leading again to the final product). The dependences enable to determine the type of the relatively stable intermediate products and the ratios of the rate constants. The theory was applied to the oxidation of four symmetrically disulphonated naphthidines with cerium(IV) sulphate in aqueous sulphuric acid and the results were substantiated spectrophotometrically

scholarly journals AN OXIDATION PRODUCT OF CREATINE

1918 ◽  
Vol 35 (2) ◽  
pp. 277-280
Author(s):  
Louis Baumann ◽  
Thorsten Ingvaldsen
Keyword(s):  
Oxidation Product

scholarly journals Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes

2021 ◽  
Author(s):  
Anna Mieszkowska ◽  
Koleta Hemine ◽  
Anna Skwierawska ◽  
Ewa Augustin ◽  
Zofia Mazerska
Keyword(s):  
Phase I ◽  
Rat Liver ◽  
Phase Ii ◽  
Oxidation Product ◽  
Liver Microsomes ◽  
Correct Selection ◽  
Rat Liver Microsomes ◽  
Recombinant Enzymes ◽  
Data Set ◽  
Phase I Enzymes

AbstractThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase II, including UGT, often creates problems in correct selection of valuable compounds. Moreover, microsomes data set is richer in the contest and provides medical scientist to determine also the susceptibility of drugs to undergo phase I and then phase II. In the present work, we have shown that IS-noh was metabolized in vitro by phase I enzymes to the oxidation product, which was next transformed with UGTs to glucuronide. The results showed also that the previously known oxidation product of opipramol was changed to previously no reported glucuronidation product by UDP-glucuronosyltransferases. In addition, unlike IS-noh, opipramol did not prove to be the substrate for UGTs. Therefore, tricyclic antidepressants depending on the structure can trigger a different response after contact with UGT enzymes. Some will metabolize directly with UGTs, others only after activation by phase I enzymes.

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