Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library

LaTeca S. Glass; Aditi Bapat; Mark R. Kelley; Millie M. Georgiadis; Eric C. Long

doi:10.1016/j.bmcl.2010.01.033

Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.01.033 ◽

2010 ◽

Vol 20 (5) ◽

pp. 1685-1688 ◽

Cited By ~ 18

Author(s):

LaTeca S. Glass ◽

Aditi Bapat ◽

Mark R. Kelley ◽

Millie M. Georgiadis ◽

Eric C. Long

Keyword(s):

Dna Binding ◽

High Throughput ◽

Compound Library ◽

Binding Agents ◽

Dna Binding Agents ◽

Displacement Based ◽

Fluorescent Intercalator Displacement ◽

Large Compound

Total Synthesis of Distamycin A and 2640 Analogues: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity

Journal of the American Chemical Society ◽

10.1021/ja994192d ◽

2000 ◽

Vol 122 (27) ◽

pp. 6382-6394 ◽

Cited By ~ 146

Author(s):

Dale L. Boger ◽

Brian E. Fink ◽

Michael P. Hedrick

Keyword(s):

Dna Binding ◽

Total Synthesis ◽

High Throughput ◽

Solution Phase ◽

Combinatorial Approach ◽

Distamycin A ◽

Binding Agents ◽

Dna Binding Agents ◽

Dna Binding Affinity ◽

Binding Sequence

A High-Throughput, High-Resolution Strategy for the Study of Site-Selective DNA Binding Agents: Analysis of a “Highly Twisted” Benzimidazole-Diamidine

Journal of the American Chemical Society ◽

10.1021/ja0600936 ◽

2006 ◽

Vol 128 (24) ◽

pp. 7846-7854 ◽

Cited By ~ 27

Author(s):

Kristie D. Goodwin ◽

Mark A. Lewis ◽

Farial A. Tanious ◽

Richard R. Tidwell ◽

W. David Wilson ◽

...

Keyword(s):

High Resolution ◽

Dna Binding ◽

High Throughput ◽

Binding Agents ◽

Dna Binding Agents ◽

Resolution Strategy ◽

Selective Dna Binding ◽

Site Selective

Preface to Sequence-specific DNA Binding Agents

DNA-targeting Molecules as Therapeutic Agents - Chemical Biology ◽

10.1039/9781788012928-fp005 ◽

2018 ◽

pp. P005-P006

Keyword(s):

Dna Binding ◽

Binding Agents ◽

Dna Binding Agents

Faculty Opinions recommendation of Total synthesis of proximicin A-C and synthesis of new furan-based DNA binding agents.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1166298.627246 ◽

2009 ◽

Author(s):

Robert Fecik

Keyword(s):

Dna Binding ◽

Total Synthesis ◽

Binding Agents ◽

Dna Binding Agents

Binding mode and affinity studies of DNA-binding agents using topoisomerase I DNA unwinding assay

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.11.038 ◽

2007 ◽

Vol 17 (4) ◽

pp. 1013-1017 ◽

Cited By ~ 22

Author(s):

Ruel E. McKnight ◽

Aaron B. Gleason ◽

James A. Keyes ◽

Sadia Sahabi

Keyword(s):

Dna Binding ◽

Topoisomerase I ◽

Binding Mode ◽

Dna Unwinding ◽

Binding Agents ◽

Dna Binding Agents

Molecular Recognition of DNA Binding Agents: High-Field 1H and 3 1P One- and Two-Dimensional NMR Studies on the 1:1 Intercalation Complexes of Mitoxantrone with Selected Oligodeoxyribonucleotides

Mechanisms of DNA Damage and Repair ◽

10.1007/978-1-4615-9462-8_22 ◽

1986 ◽

pp. 211-218

Author(s):

Albin Otter ◽

Christopher C. Hanstock ◽

George Kotovych ◽

Bernard Rayner ◽

Jacques J. Vasseur ◽

...

Keyword(s):

Dna Binding ◽

Molecular Recognition ◽

High Field ◽

Two Dimensional ◽

Nmr Studies ◽

Intercalation Complexes ◽

Binding Agents ◽

Dna Binding Agents

Recent Advances in Multinuclear Complexes as Potential Anticancer and DNA Binding Agents

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/18715206113139990313 ◽

2014 ◽

Vol 14 (1) ◽

pp. 147-169 ◽

Cited By ~ 22

Author(s):

Kehua Wang ◽

Enjun Gao

Keyword(s):

Dna Binding ◽

Recent Advances ◽

Multinuclear Complexes ◽

Binding Agents ◽

Dna Binding Agents

Synthesis of Novel Pyrazole Derivatives as Promising DNA-Binding Agents and Evaluation of Antitumor and Antitopoisomerases I/II Activities

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.c18-00546 ◽

2018 ◽

Vol 66 (11) ◽

pp. 1065-1071 ◽

Cited By ~ 3

Author(s):

Jiajia Feng ◽

Hui Qi ◽

Xiaoyang Sun ◽

Siran Feng ◽

Zhenming Liu ◽

...

Keyword(s):

Dna Binding ◽

Pyrazole Derivatives ◽

Binding Agents ◽

Dna Binding Agents

Dihydroimidazophenanthridinium (DIP)-Based DNA Binding Agents with Tuneable Structures and Biological Activity

ChemBioChem ◽

10.1002/cbic.200600205 ◽

2006 ◽

Vol 7 (11) ◽

pp. 1757-1763 ◽

Cited By ~ 17

Author(s):

Louise V. Smith ◽

Alexis D. C. Parenty ◽

Kevin M. Guthrie ◽

Jane Plumb ◽

Robert Brown ◽

...

Keyword(s):

Biological Activity ◽

Dna Binding ◽

Binding Agents ◽

Dna Binding Agents

Polyethylene glycol-bonded triethylammonium l-prolinate: a new biodegradable amino-acid-based ionic liquid for the one-pot synthesis of bis(pyrazolyl)methanes as DNA binding agents

New Journal of Chemistry ◽

10.1039/d0nj02682d ◽

2020 ◽

Vol 44 (39) ◽

pp. 16995-17012

Author(s):

Reza Kordnezhadian ◽

Mohsen Shekouhy ◽

Somaye Karimian ◽

Zohreh Tavaf ◽

Saeed Malek-Hosseini ◽

...

Keyword(s):

Ionic Liquid ◽

Polyethylene Glycol ◽

Amino Acid ◽

Dna Binding ◽

One Pot ◽

One Pot Synthesis ◽

Binding Agents ◽

Dna Binding Agents ◽

The One

[PEG-TEA]LP, as a new biodegradable ionic liquid catalyst, was successfully synthesized, characterized, and applied to the one-pot pseudo-five-component synthesis of bis(pyrazolyl)methanes.