Regulating the Anticancer Efficacy of Sgc8–Combretastatin A4 Conjugates: A Case of Recognizing the Significance of Linker Chemistry for the Design of Aptamer-Based Targeted Drug Delivery Strategies

2021 ◽  
Author(s):  
Zhiyong Huang ◽  
Dan Wang ◽  
Cheng-Yu Long ◽  
Shen-Huan Li ◽  
Xue-Qiang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Anticancer Efficacy ◽  
Combretastatin A4 ◽  
Delivery Strategies ◽  
Targeted Drug

Hyaluronic Acid-Coated Camptothecin Nanocrystals for Targeted Drug Delivery to Enhance Anticancer Efficacy

2020 ◽  
Vol 17 (7) ◽  
pp. 2411-2425
Author(s):  
Jihui Wang ◽  
Nazim Muhammad ◽  
Tongtong Li ◽  
Han Wang ◽  
Yujia Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Anticancer Efficacy ◽  
Targeted Drug

scholarly journals Emerging skin-targeted drug delivery strategies to engineer immunity: A focus on infectious diseases

2020 ◽  
pp. 1-17
Author(s):  
Emrullah Korkmaz ◽  
Stephen C. Balmert ◽  
Cara Donahue Carey ◽  
Geza Erdos ◽  
Louis D. Falo
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Targeted Drug Delivery ◽  
Delivery Strategies ◽  
Targeted Drug

Novel methotrexate prodrug-targeted drug delivery system based on PEG–lipid–PLA hybrid nanoparticles for enhanced anticancer efficacy and reduced toxicity of mitomycin C

2014 ◽  
Vol 2 (38) ◽  
pp. 6534-6548 ◽  
Author(s):  
Yang Li ◽  
Jinyan Lin ◽  
Hongjie Wu ◽  
Mengmeng Jia ◽  
Conghui Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Late Phase ◽  
Hybrid Nanoparticles ◽  
Anticancer Effect ◽  
Anticancer Efficacy ◽  
Targeted Drug ◽  
Reduced Toxicity ◽  
Targeting Effect ◽  
Targeted Drug Delivery System

Lipid–MMC in cooperation with pegylated lipid–MTX based on PEG–PE–PLA hybrid NPs can coordinate an early-phase targeting effect with a late-phase anticancer effect.

scholarly journals Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases

2009 ◽  
Vol 7 (suppl_1) ◽  
Author(s):  
Wiebke Ulbrich ◽  
Alf Lamprecht
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Inflammatory Diseases ◽  
Site Of Action ◽  
Specific Uptake ◽  
Inflammatory Bowel ◽  
Delivery Strategies ◽  
Targeted Drug ◽  
High Doses

Limitations in therapy induced by adverse effects due to unselective drug availability and therefore the use of potentially too high doses are a common problem. One prominent example for this dilemma are inflammatory diseases. Colloidal carriers allow one to improve delivery of drugs to the site of action and appear promising to overcome this general therapeutic drawback. Specific uptake of nanoparticles by immune-related cells in inflamed barriers offers selective drug targeting to the inflamed tissue. Here we focus on nanocarrier-based drug delivery strategies for the treatment of common inflammatory disorders like rheumatoid arthritis, multiple sclerosis, uveitis or inflammatory bowel disease.

scholarly journals Brain tumor-targeted drug delivery strategies

2014 ◽  
Vol 4 (3) ◽  
pp. 193-201 ◽  
Author(s):  
Xiaoli Wei ◽  
Xishan Chen ◽  
Man Ying ◽  
Weiyue Lu
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Targeted Drug Delivery ◽  
Delivery Strategies ◽  
Targeted Drug

Synthesis and biological evaluation of dual functionalized glutathione sensitive poly(ester-urethane) multiblock polymeric nanoparticles for cancer targeted drug delivery

2015 ◽  
Vol 6 (43) ◽  
pp. 7603-7617 ◽  
Author(s):  
Arun Kumar ◽  
Shantanu V. Lale ◽  
Farhat Naz ◽  
Veena Choudhary ◽  
Veena Koul
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Biological Evaluation ◽  
Anticancer Efficacy ◽  
Redox Responsive ◽  
Targeted Drug ◽  
Synthesis And Biological Evaluation

Dual targeted redox responsive doxorubicin loaded polymeric nanoparticles were prepared and evaluated for anticancer efficacy.

scholarly journals Liposomal Tumor Targeting in Drug Delivery Utilizing MMP-2- and MMP-9-Binding Ligands

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Oula Penate Medina ◽  
Merja Haikola ◽  
Marja Tahtinen ◽  
Ilkka Simpura ◽  
Sami Kaukinen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Phage Display ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Treatment Options ◽  
Delivery Vehicle ◽  
High Affinity ◽  
Binding Peptides ◽  
Delivery Strategies ◽  
Targeted Drug

Nanotechnology offers an alternative to conventional treatment options by enabling different drug delivery and controlled-release delivery strategies. Liposomes being especially biodegradable and in most cases essentially nontoxic offer a versatile platform for several different delivery approaches that can potentially enhance the delivery and targeting of therapies to tumors. Liposomes penetrate tumors spontaneously as a result of fenestrated blood vessels within tumors, leading to known enhanced permeability and subsequent drug retention effects. In addition, liposomes can be used to carry radioactive moieties, such as radiotracers, which can be bound at multiple locations within liposomes, making them attractive carriers for molecular imaging applications. Phage display is a technique that can deliver various high-affinity and selectivity peptides to different targets. In this study, gelatinase-binding peptides, found by phage display, were attached to liposomes by covalent peptide-PEG-PE anchor creating a targeted drug delivery vehicle. Gelatinases as extracellular targets for tumor targeting offer a viable alternative for tumor targeting. Our findings show that targeted drug delivery is more efficient than non-targeted drug delivery.

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