Compartmentalization Technologies via Self-Assembly and Cross-Linking of Amphiphilic Random Block Copolymers in Water

2017 ◽  
Vol 139 (21) ◽  
pp. 7164-7167 ◽  
Author(s):  
Mayuko Matsumoto ◽  
Takaya Terashima ◽  
Kazuma Matsumoto ◽  
Mikihito Takenaka ◽  
Mitsuo Sawamoto
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Cross Linking ◽  
Random Block ◽  
Amphiphilic Random Block Copolymers

Design of stimuli-responsive nanoparticles with optoelectronic cores by post-assembly cross-linking and self-assembly of functionalized block copolymers

Polymer ◽  
2016 ◽  
Vol 86 ◽  
pp. 56-68 ◽  
Author(s):  
Kazuhiro Nakabayashi ◽  
Daiki Noda ◽  
Tomoki Takahashi ◽  
Hideharu Mori
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Cross Linking ◽  
Stimuli Responsive

scholarly journals A facile strategy for manipulating micellar size and morphology through intramolecular cross-linking of amphiphilic block copolymers

2017 ◽  
Vol 8 (23) ◽  
pp. 3647-3656 ◽  
Author(s):  
Ryoto Tanaka ◽  
Kodai Watanabe ◽  
Takuya Yamamoto ◽  
Kenji Tajima ◽  
Takuya Isono ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
Amphiphilic Block Copolymers ◽  
Amphiphilic Block Copolymer ◽  
Cross Linking ◽  
Micellar Size ◽  
System P ◽  
Assembly Behavior ◽  
Size And Morphology

The effect of intramolecular cross-linking on aqueous self-assembly behavior was systematically investigated based on an amphiphilic block copolymer system.

scholarly journals Supramolecular Functionalizable Linear–Dendritic Block Copolymers for the Preparation of Nanocarriers by Microfluidics

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 684 ◽  
Author(s):  
Miriam Abad ◽  
Alejandro Martínez-Bueno ◽  
Gracia Mendoza ◽  
Manuel Arruebo ◽  
Luis Oriol ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
The Self ◽  
Cross Linking ◽  
Spectroscopic Techniques ◽  
Polymeric Nanocarriers ◽  
Transmission Electron ◽  
Click Coupling ◽  
Drug Nanocarriers ◽  
Fast Synthesis

Hybrid linear–dendritic block copolymers (LDBCs) having dendrons with a precise number of peripheral groups that are able to supramolecular bind functional moieties are challenging materials as versatile polymeric platforms for the preparation of functional polymeric nanocarriers. PEG2k-b-dxDAP LDBCs that are based on polyethylene glycol (PEG) as hydrophilic blocks and dendrons derived from bis-MPA having 2,6-diacylaminopyridine (DAP) units have been efficiently synthesized by the click coupling of preformed blocks, as was demonstrated by spectroscopic techniques and mass spectrometry. Self-assembly ability was first checked by nanoprecipitation. A reproducible and fast synthesis of aggregates was accomplished by microfluidics optimizing the total flow rate and phase ratio to achieve spherical micelles and/or vesicles depending on dendron generation and experimental parameters. The morphology and size of the self-assemblies were studied by TEM, Cryogenic Transmission Electron Microscopy (cryo-TEM), and Dynamic Light Scattering (DLS). The cytotoxicity of aggregates synthesized by microfluidics and the influence on apoptosis and cell cycle evaluation was studied on four cell lines. The self-assemblies are not cytotoxic at doses below 0.4 mg mL−1. Supramolecular functionalization using thymine derivatives was explored for reversibly cross-linking the hydrophobic blocks. The results open new possibilities for their use as drug nanocarriers with a dynamic cross-linking to improve nanocarrier stability but without hindering disassembly to release molecular cargoes.

Self-Assembly and Photo-Cross-Linking of Eight-Armed PEG-PTMC Star Block Copolymers

2011 ◽  
Vol 12 (7) ◽  
pp. 2746-2754 ◽  
Author(s):  
Sytze J. Buwalda ◽  
Laura B. Perez ◽  
Sandra Teixeira ◽  
Lucia Calucci ◽  
Claudia Forte ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Cross Linking ◽  
Star Block Copolymers

Self-Assembly Behavior and Biocompatible Cross-Linking of Double Hydrophilic Linear-Brush Block Copolymers

2017 ◽  
Vol 18 (11) ◽  
pp. 3695-3705 ◽  
Author(s):  
Noah Al Nakeeb ◽  
Jochen Willersinn ◽  
Bernhard V. K. J. Schmidt
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Cross Linking ◽  
Assembly Behavior
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