Encoding Carbon Nanotubes with Tubular Nucleic Acids for Information Storage

2019 ◽  
Vol 141 (44) ◽  
pp. 17861-17866 ◽  
Author(s):  
Yueyue Zhang ◽  
Fan Li ◽  
Min Li ◽  
Xiuhai Mao ◽  
Xinxin Jing ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Nucleic Acids ◽  
Information Storage

scholarly journals De Novo Nucleic Acids: A Review of Synthetic Alternatives to DNA and RNA That Could Act as Bio-Information Storage Molecules

Life ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 346
Author(s):  
Kevin G Devine ◽  
Sohan Jheeta
Keyword(s):  
Nucleic Acids ◽  
Genetic Information ◽  
De Novo ◽  
Chemical Properties ◽  
Amino Acid Sequences ◽  
Information Storage ◽  
Heterocyclic Base ◽  
Dna And Rna ◽  
Phosphate Backbone ◽  
Physical And Chemical

Modern terran life uses several essential biopolymers like nucleic acids, proteins and polysaccharides. The nucleic acids, DNA and RNA are arguably life’s most important, acting as the stores and translators of genetic information contained in their base sequences, which ultimately manifest themselves in the amino acid sequences of proteins. But just what is it about their structures; an aromatic heterocyclic base appended to a (five-atom ring) sugar-phosphate backbone that enables them to carry out these functions with such high fidelity? In the past three decades, leading chemists have created in their laboratories synthetic analogues of nucleic acids which differ from their natural counterparts in three key areas as follows: (a) replacement of the phosphate moiety with an uncharged analogue, (b) replacement of the pentose sugars ribose and deoxyribose with alternative acyclic, pentose and hexose derivatives and, finally, (c) replacement of the two heterocyclic base pairs adenine/thymine and guanine/cytosine with non-standard analogues that obey the Watson–Crick pairing rules. This manuscript will examine in detail the physical and chemical properties of these synthetic nucleic acid analogues, in particular on their abilities to serve as conveyors of genetic information. If life exists elsewhere in the universe, will it also use DNA and RNA?

scholarly journals Hybrids of Nucleic Acids and Carbon Nanotubes for Nanobiotechnology

Nanomaterials ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 321-350 ◽  
Author(s):  
Kazuo Umemura
Keyword(s):  
Carbon Nanotubes ◽  
Nucleic Acids

Nucleic acids: function and potential for abiogenesis

2017 ◽  
Vol 50 ◽  
Author(s):  
Falk Wachowius ◽  
James Attwater ◽  
Philipp Holliger
Keyword(s):  
Nucleic Acids ◽  
Prebiotic Chemistry ◽  
Molecular Level ◽  
Rna World ◽  
Information Storage ◽  
Molecular Systems ◽  
Rna Molecules ◽  
Functional Potential ◽  
Self Replication ◽  
Uniform Composition

AbstractThe emergence of functional cooperation between the three main classes of biomolecules – nucleic acids, peptides and lipids – defines life at the molecular level. However, how such mutually interdependent molecular systems emerged from prebiotic chemistry remains a mystery. A key hypothesis, formulated by Crick, Orgel and Woese over 40 year ago, posits that early life must have been simpler. Specifically, it proposed that an early primordial biology lacked proteins and DNA but instead relied on RNA as the key biopolymer responsible not just for genetic information storage and propagation, but also for catalysis, i.e. metabolism. Indeed, there is compelling evidence for such an ‘RNA world’, notably in the structure of the ribosome as a likely molecular fossil from that time. Nevertheless, one might justifiably ask whether RNA alone would be up to the task. From a purely chemical perspective, RNA is a molecule of rather uniform composition with all four bases comprising organic heterocycles of similar size and comparable polarity and pKa values. Thus, RNA molecules cover a much narrower range of steric, electronic and physicochemical properties than, e.g. the 20 amino acid side-chains of proteins. Herein we will examine the functional potential of RNA (and other nucleic acids) with respect to self-replication, catalysis and assembly into simple protocellular entities.

scholarly journals Interaction of nucleic acids with carbon nanotubes and dendrimers

2012 ◽  
Vol 37 (3) ◽  
pp. 457-474 ◽  
Author(s):  
Bidisha Nandy ◽  
Mogurampelly Santosh ◽  
Prabal K Maiti
Keyword(s):  
Carbon Nanotubes ◽  
Nucleic Acids

scholarly journals Synthetic Life with Alternative Nucleic Acids as Genetic Materials

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3483
Author(s):  
Peng Nie ◽  
Yanfen Bai ◽  
Hui Mei
Keyword(s):  
Nucleic Acids ◽  
Genetic Information ◽  
Structural Parameters ◽  
Living Cells ◽  
Information Storage ◽  
Chemically Modified ◽  
Synthetic Life ◽  
Living Organisms

DNA, the fundamental genetic polymer of all living organisms on Earth, can be chemically modified to embrace novel functions that do not exist in nature. The key chemical and structural parameters for genetic information storage, heredity, and evolution have been elucidated, and many xenobiotic nucleic acids (XNAs) with non-canonical structures are developed as alternative genetic materials in vitro. However, it is still particularly challenging to replace DNAs with XNAs in living cells. This review outlines some recent studies in which the storage and propagation of genetic information are achieved in vivo by expanding genetic systems with XNAs.

Novel Multifunctional Hybrids of Single-Walled Carbon Nanotubes with Nucleic Acids: Synthesis and Interactions with Living Cells

2014 ◽  
Vol 6 (3) ◽  
pp. 1454-1461 ◽  
Author(s):  
Evgeny K. Apartsin ◽  
Marina Yu. Buyanova ◽  
Darya S. Novopashina ◽  
Elena I. Ryabchikova ◽  
Anton V. Filatov ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Nucleic Acids ◽  
Single Walled Carbon Nanotubes ◽  
Living Cells ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes
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