Multimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine

2020 ◽  
Vol 31 (12) ◽  
pp. 2401-2415
Author(s):  
Elizabeth K. Neumann ◽  
Katerina V. Djambazova ◽  
Richard M. Caprioli ◽  
Jeffrey M. Spraggins
Keyword(s):  
Mass Spectrometry ◽  
Multimodal Imaging ◽  
Molecular Mapping ◽  
Imaging Mass Spectrometry ◽  
Next Generation

P2-152: Molecular mapping of Alzheimer's disease: Imaging mass spectrometry

2015 ◽  
Vol 11 (7S_Part_11) ◽  
pp. P545-P545
Author(s):  
George Perry ◽  
Andrea Renee Kelley ◽  
Stephan Bach ◽  
Rudolph J. Castellani
Keyword(s):  
Mass Spectrometry ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Mapping ◽  
Imaging Mass Spectrometry

Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry

2021 ◽  
Author(s):  
Jarod A. Fincher ◽  
Katerina V. Djambazova ◽  
Dustin R. Klein ◽  
Martin Dufresne ◽  
Lukasz G. Migas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Mapping ◽  
Neutral Lipids ◽  
Imaging Mass Spectrometry

scholarly journals Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

2019 ◽  
Vol 116 (44) ◽  
pp. 21980-21982 ◽  
Author(s):  
William J. Perry ◽  
Jeffrey M. Spraggins ◽  
Jessica R. Sheldon ◽  
Caroline M. Grunenwald ◽  
David E. Heinrichs ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Staphylococcus Aureus ◽  
Small Molecules ◽  
Multimodal Imaging ◽  
Imaging Mass Spectrometry ◽  
Infected Tissue ◽  
Siderophore Production ◽  
Vertebrate Host ◽  
Nutritional Immunity ◽  
Iron Competition

Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host−pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of Staphylococcus aureus siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly iron-depleted environment to invading microbes.

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