Capillary Electrophoresis–High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer’s Disease Mouse Models

2021 ◽  
Author(s):  
Kendra J. Adams ◽  
Joan G. Wilson ◽  
David S. Millington ◽  
M. Arthur Moseley ◽  
Carol A. Colton ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Alzheimer’S Disease ◽  
Capillary Electrophoresis ◽  
High Resolution ◽  
Mouse Models ◽  
High Resolution Mass Spectrometry ◽  
Isotope Incorporation ◽  
High Resolution Mass ◽  
Resolution Mass

P3-025: Characterization of transthyretin isoforms in CSF from patients with Alzheimer's disease and controls by high resolution mass spectrometry

2009 ◽  
Vol 5 (4S_Part_11) ◽  
pp. P347-P347
Author(s):  
Keld Poulsen ◽  
Justyna M.C. Bahl ◽  
Anja H. Simonsen ◽  
Gunhild Waldemar ◽  
Martin R. Larsen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Resolution Mass

scholarly journals Identification and Distribution of Novel Metabolites of Lolitrem B in Mice by High-Resolution Mass Spectrometry

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 372 ◽  
Author(s):  
Priyanka Reddy ◽  
Aaron Elkins ◽  
Joanne Hemsworth ◽  
Kathryn Guthridge ◽  
Simone Vassiliadis ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Brain Regions ◽  
High Resolution Mass ◽  
Metabolic Products ◽  
Severe Intoxication ◽  
Lolitrem B ◽  
Resolution Mass

Lolitrem B is the most potent indole-diterpene mycotoxin produced by Epichloë festucae var. lolii (termed LpTG-1), with severe intoxication cases reported in livestock. To date, there are no in vivo metabolism studies conducted for the mycotoxin. A mouse model assay established for assessing toxicity of indole-diterpenes was used to investigate metabolic products of lolitrem B. Mice were administered lolitrem B at 0.5 and 2.0 mg/kg body weight (b.wt) intraperitoneally before body and brain tissues were collected at 6 h and 24 h post-treatment. Samples were cryoground and subjected to a biphasic or monophasic extraction. The aqueous and lipophilic phases were analysed using liquid chromatography high-resolution mass spectrometry (LC–HRMS); data analysis was performed with Compound Discoverer™ software. A total of 10 novel phase I metabolic products were identified in the lipophilic phase and their distribution in the liver, kidney and various brain regions are described. The biotransformation products of lolitrem B were found to be present in low levels in the brain. Based on structure–activity postulations, six of these may contribute towards the protracted tremors exhibited by lolitrem B-exposed animals.

In vitro and in vivo metabolism of 3-quinuclidinyl benzilate by high-resolution mass spectrometry

2020 ◽  
Vol 190 ◽  
pp. 113519
Author(s):  
Martin Uher ◽  
Martin Mžik ◽  
Jana Žďárová Karasová ◽  
David Herman ◽  
Lenka Čechová ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
In Vivo Metabolism ◽  
High Resolution Mass ◽  
Resolution Mass ◽  
Quinuclidinyl Benzilate

Hyaluronidase reaction kinetics evaluated by capillary electrophoresis with UV and high-resolution mass spectrometry (HRMS) detection

2017 ◽  
Vol 951 ◽  
pp. 140-150 ◽  
Author(s):  
Syntia Fayad ◽  
Reine Nehmé ◽  
Monika Langmajerová ◽  
Benjamin Ayela ◽  
Cyril Colas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Capillary Electrophoresis ◽  
High Resolution ◽  
Reaction Kinetics ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Resolution Mass
Sign in / Sign up

Export Citation Format

Share Document