Will the Digital Mass Filter Be the Next High-Resolution High-Mass Analyzer?

2021 ◽  
Author(s):  
Peter T. A. Reilly ◽  
Sumeet Chakravorty ◽  
Conner F. Bailey ◽  
Fatima O. Obe ◽  
Adam P. Huntley
Keyword(s):  
High Resolution ◽  
High Mass ◽  
Mass Analyzer ◽  
Mass Filter

scholarly journals Ultra High-Mass Resolution Paper Spray by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Kevin D. Quinn ◽  
Charmion I. Cruickshank ◽  
Troy D. Wood
Keyword(s):  
Fourier Transform ◽  
High Resolution ◽  
Cyclotron Resonance ◽  
Lung Surfactant ◽  
Resolving Power ◽  
High Mass ◽  
Mass Analyzer ◽  
Ion Cyclotron Resonance ◽  
Paper Spray ◽  
Ion Cyclotron

Paper Spray Ionization is an atmospheric pressure ionization technique that utilizes an offline electro-osmotic flow to generate ions off a paper medium. This technique can be performed on a Bruker SolariX Fourier transform ion cyclotron resonance mass spectrometer by modifying the existing nanospray source. High-resolution paper spray spectra were obtained for both organic and biological samples to demonstrate the benefit of linking the technique with a high-resolution mass analyzer. Error values in the range 0.23 to 2.14 ppm were obtained for calf lung surfactant extract with broadband mass resolving power (m/Δm50%) above 60,000 utilizing an external calibration standard.

Possibility of operating quadrupole mass filter at high resolution

2016 ◽  
Vol 408 ◽  
pp. 9-19 ◽  
Author(s):  
Mikhail Sudakov ◽  
Eugenij Mamontov ◽  
Fuxing Xu ◽  
Chongsheng Xu ◽  
Chuan-Fan Ding
Keyword(s):  
High Resolution ◽  
Quadrupole Mass Filter ◽  
Quadrupole Mass ◽  
Mass Filter

A high resolution multi-turn TOF mass analyzer

2019 ◽  
Vol 34 (36) ◽  
pp. 1942005 ◽  
Author(s):  
Vyacheslav Shchepunov ◽  
Michael Rignall ◽  
Roger Giles ◽  
Ryo Fujita ◽  
Hiroaki Waki ◽  
...  
Keyword(s):  
High Resolution ◽  
Mirror Symmetry ◽  
Rotational Symmetry ◽  
Optical Design ◽  
Resolving Power ◽  
Mass Analyzer ◽  
Rotationally Symmetric ◽  
Mass Resolving Power ◽  
Operational Modes ◽  
Drift Direction

An ion optical design of a high resolution multi-turn time-of-flight mass analyzer (MT-TOF MA) is presented. The analyzer has rotationally symmetric main electrodes with additional mirror symmetry about a mid-plane orthogonal to the axis of symmetry. Rotational symmetry allows a higher density of turns in the azimuthal (drift) direction compared to MT-TOF MAs that are linearly extended in the drift direction. Mirror symmetry about a mid-plane helps to achieve a high spatial isochronicity of the ions’ motion. The analyzer comprises a pair of polar-toroidal sectors S1 and S3, a pair of polar (trans-axial) lenses, and a pair of conical lenses for longitudinal and lateral focusing. A toroidal sector S2 located at the mid-plane of the analyzer has a set of embedded drift focusing segments providing focusing and spatial isochronicity in the drift direction. The ions’ drift in the azimuthal direction can be reversed by using dedicated reversing deflectors. This gives the possibility of several operational modes with different numbers of turns and passes in the drift direction. According to numerical simulations, the mass resolving power of the analyzer ranges from [Formula: see text]40 k (fwhm) at small (typically below ten) numbers of turns to [Formula: see text]450 k (fwhm) at 96 turns.

High resolution spectroscopy of X-ray emission from high mass X-ray binaries

2006 ◽  
Vol 38 (12) ◽  
pp. 2737-2741
Author(s):  
F. Nagase ◽  
S. Watanabe
Keyword(s):  
High Resolution ◽  
High Resolution Spectroscopy ◽  
High Mass ◽  
X Ray ◽  
X Ray Binaries

scholarly journals Characterizing filaments in regions of high-mass star formation: High-resolution submilimeter imaging of the massive star-forming complex NGC 6334 with ArTéMiS

2016 ◽  
Vol 592 ◽  
pp. A54 ◽  
Author(s):  
Ph. André ◽  
V. Revéret ◽  
V. Könyves ◽  
D. Arzoumanian ◽  
J. Tigé ◽  
...  
Keyword(s):  
Star Formation ◽  
High Resolution ◽  
Massive Star ◽  
High Mass ◽  
Mass Star ◽  
Star Forming ◽  
Ngc 6334

scholarly journals A high resolution spectrometer for the study of high mass muon pairs produced by intense hadron beams

1984 ◽  
Vol 223 (1) ◽  
pp. 26-39 ◽  
Author(s):  
L. Anderson ◽  
R. Benetta ◽  
J.D. Berst ◽  
B. Betev ◽  
J.J. Blaising ◽  
...  
Keyword(s):  
High Resolution ◽  
High Mass ◽  
Muon Pairs ◽  
High Resolution Spectrometer ◽  
Resolution Spectrometer

scholarly journals Precision proteomics: The case for high resolution and high mass accuracy

2008 ◽  
Vol 105 (47) ◽  
pp. 18132-18138 ◽  
Author(s):  
M. Mann ◽  
N. L. Kelleher
Keyword(s):  
High Resolution ◽  
Mass Accuracy ◽  
High Mass ◽  
High Mass Accuracy

scholarly journals Expert System for Computer-assisted Annotation of MS/MS Spectra

2012 ◽  
Vol 11 (11) ◽  
pp. 1500-1509 ◽  
Author(s):  
Nadin Neuhauser ◽  
Annette Michalski ◽  
Jürgen Cox ◽  
Matthias Mann
Keyword(s):  
Expert System ◽  
High Resolution ◽  
Search Engine ◽  
Expert Knowledge ◽  
Large Body ◽  
Mass Accuracy ◽  
High Mass ◽  
Computer Assisted ◽  
High Mass Accuracy ◽  
Almost All

An important step in mass spectrometry (MS)-based proteomics is the identification of peptides by their fragment spectra. Regardless of the identification score achieved, almost all tandem-MS (MS/MS) spectra contain remaining peaks that are not assigned by the search engine. These peaks may be explainable by human experts but the scale of modern proteomics experiments makes this impractical. In computer science, Expert Systems are a mature technology to implement a list of rules generated by interviews with practitioners. We here develop such an Expert System, making use of literature knowledge as well as a large body of high mass accuracy and pure fragmentation spectra. Interestingly, we find that even with high mass accuracy data, rule sets can quickly become too complex, leading to over-annotation. Therefore we establish a rigorous false discovery rate, calculated by random insertion of peaks from a large collection of other MS/MS spectra, and use it to develop an optimized knowledge base. This rule set correctly annotates almost all peaks of medium or high abundance. For high resolution HCD data, median intensity coverage of fragment peaks in MS/MS spectra increases from 58% by search engine annotation alone to 86%. The resulting annotation performance surpasses a human expert, especially on complex spectra such as those of larger phosphorylated peptides. Our system is also applicable to high resolution collision-induced dissociation data. It is available both as a part of MaxQuant and via a webserver that only requires an MS/MS spectrum and the corresponding peptides sequence, and which outputs publication quality, annotated MS/MS spectra (www.biochem.mpg.de/mann/tools/). It provides expert knowledge to beginners in the field of MS-based proteomics and helps advanced users to focus on unusual and possibly novel types of fragment ions.

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