scholarly journals Ethyl 1,8-Naphthyridone-3-carboxylates Downregulate Human Papillomavirus-16 E6 and E7 Oncogene Expression

2014 ◽  
Vol 57 (13) ◽  
pp. 5649-5663 ◽  
Author(s):  
Manuela Donalisio ◽  
Serena Massari ◽  
Monica Argenziano ◽  
Giuseppe Manfroni ◽  
Valeria Cagno ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Human Papillomavirus 16 ◽  
Oncogene Expression ◽  
E6 And E7 ◽  
E7 Oncogene

scholarly journals Leukemia Inhibitory Factor Downregulates Human Papillomavirus-16 Oncogene Expression and Inhibits the Proliferation of Cervical Carcinoma Cells

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Joseph M. Bay ◽  
Bruce K. Patterson ◽  
Nelson N. H. Teng
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Cells ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Human Papillomavirus 16 ◽  
Oncogene Expression ◽  
Hpv E6 ◽  
Cervical Cancer Cells ◽  
E6 And E7

The constitutive proliferation and resistance to differentiation and apoptosis of neoplastic cervical cells depend on sustained expression of human papillomavirus oncogenes. Inhibition of these oncogenes is a goal for the prevention of progression of HPV-induced neoplasias to cervical cancer. SiHa cervical cancer cells were transfected with an HPV-16 promoter reporter construct and treated with leukemia inhibitory factor (LIF), a human cytokine of the interleukin 6 superfamily. SiHa and CaSki cervical cancer cells were also assessed for proliferation by MTT precipitation, programmed cell death by flow cytometry, and HPV E6 and E7 expression by real-time PCR. LIF-treated cervical cancer cells showed significantly reduced HPV LCR activation, reduced levels of E6 and E7 mRNA, and reduced proliferation. We report the novel use of LIF to inhibit viral oncogene expression in cervical cancer cells, with concomitant reduction in proliferation suggesting re-engagement of cell-cycle regulation.

E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP)

2006 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Bahig Shehata ◽  
Kristen Otto ◽  
Steven Sobol ◽  
Christina Stockwell ◽  
Cora Foulks ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Aggressive Behavior ◽  
Laryngeal Papillomatosis ◽  
Papilloma Virus ◽  
Oncogene Expression ◽  
E6 And E7 ◽  
E7 Oncogene

scholarly journals Human Papillomavirus Genotype Distribution and E6/E7 Oncogene Expression in Turkish Women with Cervical Cytological Findings

2014 ◽  
Vol 15 (9) ◽  
pp. 3997-4003 ◽  
Author(s):  
Seda Tezcan ◽  
Didem Ozgur ◽  
Mahmut Ulger ◽  
Gonul Aslan ◽  
Iclal Gurses ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Genotype Distribution ◽  
Turkish Women ◽  
Oncogene Expression ◽  
E7 Oncogene

scholarly journals E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam

2013 ◽  
Vol 85 (6) ◽  
pp. 1069-1076 ◽  
Author(s):  
Azumi Ishizaki ◽  
Kaori Matsushita ◽  
Huyen Thi Thanh Hoang ◽  
Dorothy M. Agdamag ◽  
Cuong Hung Nguyen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
The Philippines ◽  
Human Papillomavirus 16 ◽  
E6 And E7
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