Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series

Rafaela S. Ferreira; Clifford Bryant; Kenny K. H. Ang; James H. McKerrow; Brian K. Shoichet; Adam R. Renslo

doi:10.1021/jm9009229

Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series

Journal of Medicinal Chemistry ◽

10.1021/jm9009229 ◽

2009 ◽

Vol 52 (16) ◽

pp. 5005-5008 ◽

Cited By ~ 59

Author(s):

Rafaela S. Ferreira ◽

Clifford Bryant ◽

Kenny K. H. Ang ◽

James H. McKerrow ◽

Brian K. Shoichet ◽

...

Keyword(s):

Enzyme Inhibition ◽

Structure Activity ◽

Homologous Structure ◽

Activity Series

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Convergent synthesis of carbonic anhydrase inhibiting bi‐heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.4240 ◽

2021 ◽

Author(s):

Farhan M. Khan ◽

Muhammad A. Abbasi ◽

Aziz‐ur‐Rehman ◽

Sabahat Z. Siddiqui ◽

Abdul R. Sadiq Butt ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Enzyme Inhibition ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Computational Studies ◽

Inhibition Kinetics ◽

Convergent Synthesis ◽

Structure Activity ◽

Enzyme Inhibition Kinetics

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Quantitative Structure-Activity Relationships for Organophosphate Enzyme Inhibition

ACS Symposium Series - Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment ◽

10.1021/bk-2012-1099.ch017 ◽

2012 ◽

pp. 271-290

Author(s):

Christopher D. Ruark ◽

C. Eric Hack ◽

Peter J. Robinson ◽

Jeffery M. Gearhart

Keyword(s):

Enzyme Inhibition ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Fluoro-benzimidazole derivatives to cure Alzheimer’s disease: In-silico studies, synthesis, structure-activity relationship and in vivo evaluation for β secretase enzyme inhibition

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.102936 ◽

2019 ◽

Vol 88 ◽

pp. 102936 ◽

Cited By ~ 1

Author(s):

Sayyad Ali ◽

Muhammad Hassham Hassan Bin Asad ◽

Soham Maity ◽

Wahid Zada ◽

Albert A. Rizvanov ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Enzyme Inhibition ◽

In Silico ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Benzimidazole Derivatives ◽

In Vivo Evaluation ◽

Structure Activity ◽

In Silico Studies

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Design, synthesis, structure–activity relationship and antibacterial activity series of novel imidazo fused quinolone carboxamides

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2008.07.024 ◽

2009 ◽

Vol 44 (4) ◽

pp. 1570-1578 ◽

Cited By ~ 23

Author(s):

G. Venkat Reddy ◽

S. Ravi Kanth ◽

D. Maitraie ◽

B. Narsaiah ◽

P. Shanthan Rao ◽

...

Keyword(s):

Antibacterial Activity ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Activity Series

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Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c01214 ◽

2021 ◽

Author(s):

Arun K. Ghosh ◽

Jakka Raghavaiah ◽

Dana Shahabi ◽

Monika Yadav ◽

Brandon J. Anson ◽

...

Keyword(s):

Enzyme Inhibition ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structural Studies ◽

X Ray ◽

Antiviral Efficacy ◽

Structure Activity

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Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

ChemMedChem ◽

10.1002/cmdc.201300429 ◽

2014 ◽

Vol 9 (4) ◽

pp. 776-791 ◽

Cited By ~ 35

Author(s):

Pan Pan ◽

Susan E. Knudson ◽

Gopal R. Bommineni ◽

Huei-Jiun Li ◽

Cheng-Tsung Lai ◽

...

Keyword(s):

Antibacterial Activity ◽

Enzyme Inhibition ◽

Structure Activity Relationship ◽

Time Dependent ◽

Activity Relationship ◽

In Vivo Efficacy ◽

Structure Activity ◽

Diaryl Ether

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Enzyme Inhibition VI: Inhibition of Reverse Transcriptase Activity by Protoberberine Alkaloids and Structure–Activity Relationships

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600720515 ◽

1983 ◽

Vol 72 (5) ◽

pp. 538-541 ◽

Cited By ~ 44

Author(s):

Manohar L. Sethi

Keyword(s):

Reverse Transcriptase ◽

Enzyme Inhibition ◽

Reverse Transcriptase Activity ◽

Structure Activity Relationships ◽

Protoberberine Alkaloids ◽

Transcriptase Activity ◽

Structure Activity

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Structure–activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.09.021 ◽

2006 ◽

Vol 14 (4) ◽

pp. 1007-1020 ◽

Cited By ~ 46

Author(s):

Kristopher G. Virga ◽

Yong-Mei Zhang ◽

Roberta Leonardi ◽

Robert A. Ivey ◽

Kirk Hevener ◽

...

Keyword(s):

Enzyme Inhibition ◽

Kinase Inhibitors ◽

Pantothenate Kinase ◽

Structure Activity Relationships ◽

Structure Activity

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Simultaneous structure—activity determination of disulfiram photolysis products by on-line continuous-flow liquid secondary ion mass spectrometry and enzyme inhibition assay

Journal of Chromatography A ◽

10.1016/0021-9673(94)01101-j ◽

1995 ◽

Vol 693 (1) ◽

pp. 162-166 ◽

Cited By ~ 3

Author(s):

Linda M. Benson ◽

Karen A. Veverka ◽

Dennis C. Mays ◽

Albert N. Nelson ◽

Zachary H. Shriver ◽

...

Keyword(s):

Mass Spectrometry ◽

Enzyme Inhibition ◽

Continuous Flow ◽

Secondary Ion Mass Spectrometry ◽

Inhibition Assay ◽

Structure Activity ◽

On Line ◽

Enzyme Inhibition Assay ◽

Secondary Ion

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Competitive CYP2C9 Inhibitors: Enzyme Inhibition Studies, Protein Homology Modeling, and Three-Dimensional Quantitative Structure-Activity Relationship Analysis

Molecular Pharmacology ◽

10.1124/mol.59.4.909 ◽

2001 ◽

Vol 59 (4) ◽

pp. 909-919 ◽

Cited By ~ 58

Author(s):

Lovisa Afzelius ◽

Ismael Zamora ◽

Marianne Ridderström ◽

Tommy B. Andersson ◽

Anders Karlén ◽

...

Keyword(s):

Homology Modeling ◽

Enzyme Inhibition ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Protein Homology ◽

Relationship Analysis ◽

Structure Activity ◽

Inhibition Studies

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