enzyme inhibition assay
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scholarly journals Catechol-O-Methyltransferase Inhibitors Isolated From Thai Propolis

2021 ◽  
Vol 16 (10) ◽  
pp. 1934578X2110502
Author(s):  
Ryo Miyata ◽  
Tomoharu Motoyama ◽  
Shogo Nakano ◽  
Sohei Ito ◽  
Kazuma Mukaide ◽  
...  
Keyword(s):  
Enzyme Inhibition ◽  
Inhibitory Activity ◽  
Biological Activities ◽  
Inhibition Assay ◽  
Chiang Mai ◽  
Comt Inhibitors ◽  
Prevention And Treatment ◽  
Potential Applications ◽  
Enzyme Inhibition Assay ◽  
Functional Components

Propolis is an aggregate of functional components found in plant resins and has been reported to exhibit a variety of valuable biological activities. This study investigated the inhibitory properties of propolis from Thailand toward human catechol- O-methyltransferase (COMT), a key neurotransmitter involved in Parkinson's disease and depression. Samples collected from Chanthaburi and Chiang Mai exhibited relatively high inhibitory activity against COMT. γ-Mangostin (1) and 6-prenyleriodictyol (3) were identified as COMT inhibitors with IC50 values of 62 and 75 μM, respectively. In an enzyme inhibition assay, 1 exhibited mixed inhibition toward COMT. The results suggest that both 1 and propolis have potential applications in the prevention and treatment of psychological illness.

Synthesis, molecular docking and ADMET prediction of novel swertiamarin analogues for the restoration of type-2 diabetes: an enzyme inhibition assay

2020 ◽  
pp. 1-11
Author(s):  
Satyender Kumar ◽  
Prakash Niguram ◽  
Vedika Bhat ◽  
Seema Jinagal ◽  
Vinod Jairaj ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Molecular Docking ◽  
Enzyme Inhibition ◽  
Inhibition Assay ◽  
Enzyme Inhibition Assay

Enzyme inhibition assay for metabolic disorders—exploring leads from medicinal plants

2020 ◽  
pp. 631-653
Author(s):  
Pulok K. Mukherjee ◽  
Ranjit K. Harwansh ◽  
Shiv Bahadur ◽  
Joydeb Chanda ◽  
Sayan Biswas ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Enzyme Inhibition ◽  
Metabolic Disorders ◽  
Inhibition Assay ◽  
Enzyme Inhibition Assay

scholarly journals ANTI-DIABETIC POTENTIAL OF PEPTIDE FROM P. NIRURI REVEALS THROUGH CARBOHYDRATE HYDROLYZING ENZYME INHIBITION ASSAY

2019 ◽  
Vol 3 (1) ◽  
pp. 17-19
Author(s):  
Noor Hasniza Md Zin ◽  
Ainul Mardhiah Mohd Nail
Keyword(s):  
Enzyme Inhibition ◽  
Inhibition Assay ◽  
Enzyme Inhibition Assay

Supramolecular Heteroleptic Copper(II) Carboxylates: Synthesis, Spectral Characterization, Crystal Structures, and Enzyme Inhibition Assay

2018 ◽  
Vol 44 (3) ◽  
pp. 187-197 ◽  
Author(s):  
A. Mushtaq ◽  
S. Ali ◽  
M. Iqbal ◽  
S. Shahzadi ◽  
M. N. Tahir ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Enzyme Inhibition ◽  
Spectral Characterization ◽  
Inhibition Assay ◽  
Enzyme Inhibition Assay
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