scholarly journals Organically Modified Silica Nanoparticles with Intraparticle Heavy-Atom Effect on the Encapsulated Photosensitizer for Enhanced Efficacy of Photodynamic Therapy

2009 ◽  
Vol 113 (29) ◽  
pp. 12641-12644 ◽  
Author(s):  
Sehoon Kim ◽  
Tymish Y. Ohulchanskyy ◽  
Dhruba Bharali ◽  
Yihui Chen ◽  
Ravindra K. Pandey ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Silica Nanoparticles ◽  
Heavy Atom ◽  
Modified Silica ◽  
Heavy Atom Effect ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles ◽  
Atom Effect

Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer

Nano Letters ◽  
2007 ◽  
Vol 7 (9) ◽  
pp. 2835-2842 ◽  
Author(s):  
Tymish Y. Ohulchanskyy ◽  
Indrajit Roy ◽  
Lalit N. Goswami ◽  
Yihui Chen ◽  
Earl J. Bergey ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Silica Nanoparticles ◽  
Modified Silica ◽  
Photodynamic Therapy Of Cancer ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

scholarly journals Organically Modified Silica Nanoparticles Are Biocompatible and Can Be Targeted to Neurons In Vivo

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29424 ◽  
Author(s):  
Farda Barandeh ◽  
Phuong-Lan Nguyen ◽  
Rajiv Kumar ◽  
Gary J. Iacobucci ◽  
Michelle L. Kuznicki ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

Organically modified silica nanoparticles as drug delivery vehicles in photodynamic therapy

2011 ◽  
Vol 15 (05n06) ◽  
pp. 401-411 ◽  
Author(s):  
Anurag Gupta ◽  
Lalit N. Goswami ◽  
Manivannan Ethirajan ◽  
Joseph Missert ◽  
K.V.R. Rao ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Encapsulation Efficiency ◽  
Release Kinetics ◽  
Alkyl Ether ◽  
Modified Silica ◽  
Drug Delivery Vehicles ◽  
Organically Modified ◽  
Delivery Vehicles ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

To investigate the effect of hydrophobicity, charge and size of photosensitizers (PS) on their encapsulation efficiency in organically modified silica nanoparticles (ORMOSIL), a series of alkyl ether analogs of 2-(1′-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) containing varied number of carbon units, HPPH with anionic and cationic functionalities, and HPPH analogs with molecular weight ranging from ~630 to 6000 Daltons were synthesized. Our preliminary results suggest that these factors play a significant role in encapsulation of the photosensitizers and their release from ORMOSIL nanoparticles. The synthesis and characterization of PS-encapsulated ORMOSIL and a comparative study on the effect of PS size, lipophilicity and charge on encapsulation efficiency, photophysical characteristics and release kinetics are discussed.

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