Macrophage Uptake of Core−Shell Nanoparticles Surface Modified with Poly(ethylene glycol)

Langmuir ◽  
2006 ◽  
Vol 22 (19) ◽  
pp. 8178-8185 ◽  
Author(s):  
Alisar S. Zahr ◽  
Cheryl A. Davis ◽  
Michael V. Pishko
Keyword(s):  
Ethylene Glycol ◽  
Core Shell ◽  
Poly Ethylene Glycol ◽  
Shell Nanoparticles ◽  
Poly Ethylene ◽  
Surface Modified ◽  
Core Shell Nanoparticles ◽  
Macrophage Uptake

Synthesis of curdlan-graft-poly(ethylene glycol) and formulation of doxorubicin-loaded core–shell nanoparticles

2012 ◽  
Vol 27 (1) ◽  
pp. 3-17 ◽  
Author(s):  
Benjamin C. Lehtovaara ◽  
Mohit S. Verma ◽  
Frank X. Gu
Keyword(s):  
Ethylene Glycol ◽  
Graft Copolymer ◽  
Fickian Diffusion ◽  
High Yield ◽  
Core Shell ◽  
Hydroxyl Groups ◽  
Poly Ethylene Glycol ◽  
Shell Nanoparticles ◽  
Hemolysis Assay ◽  
Poly Ethylene

A new core–shell nanoparticle containing the chemotherapeutic drug doxorubicin was formulated via amphiphilic graft copolymer self-assembly using curdlan- graft-poly(ethylene glycol) (curdlan -g-PEG). The graft copolymer was synthesized through the dicyclohexylcarbodiimide ester linkage of carboxylated PEG to the hydroxyl groups of the curdlan backbone. The nanoparticles were 109.9 nm in size and encapsulated doxorubicin in high yield (4%–5% wt/wt). The nanoparticles also controlled the release of doxorubicin over 24 h with a release profile that followed a Fickian diffusion model. The biocompatibility of curdlan- g-PEG was confirmed by hemolysis assay. This is the first nanoparticle formulated using the hydrophobicity of curdlan for concealing the immunomodulatory potential of curdlan within the core.

Development of biocompatible hydroxyapatite–poly(ethylene glycol) core–shell nanoparticles as an improved drug carrier: structural and electrical characterizations

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 102853-102868 ◽  
Author(s):  
Ayan Manna ◽  
Sumit Pramanik ◽  
Ashis Tripathy ◽  
Ali Moradi ◽  
Zamri Radzi ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Controlled Drug Release ◽  
Release Mechanism ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Drug Release Mechanism ◽  
Poly Ethylene ◽  
Core Shell Nanoparticles ◽  
Electrical Characterizations ◽  
Shell Composite

A model of a controlled drug release mechanism of a dielectric core–shell composite carrier.

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