Multi pH-sensitive polymer–drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis

Multi pH-responsive polymer-drug conjugate mixed micelles were fabricated to co-deliver doxorubicin and curcumin for synergistic suppression tumor metastasis via inhibiting the invasion, migration, intravasation and extravasation of tumor cells.

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pH‐Responsive Polymer–Drug Conjugate: An Effective Strategy to Combat the Antimicrobial Resistance

Advanced Functional Materials ◽

10.1002/adfm.202002655 ◽

2020 ◽

Vol 30 (39) ◽

pp. 2002655 ◽

Cited By ~ 1

Author(s):

Mingzhou Ye ◽

Yi Zhao ◽

Yuyuan Wang ◽

Nisakorn Yodsanit ◽

Ruosen Xie ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Effective Strategy ◽

Ph Responsive ◽

Drug Conjugate ◽

Responsive Polymer

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Multifunctional microspherical magnetic and pH responsive carriers for combination anticancer therapy engineered by droplet-based microfluidics

Journal of Materials Chemistry B ◽

10.1039/c7tb00588a ◽

2017 ◽

Vol 5 (22) ◽

pp. 4097-4109 ◽

Cited By ~ 15

Author(s):

Shaheer Maher ◽

Abel Santos ◽

Tushar Kumeria ◽

Gagandeep Kaur ◽

Martin Lambert ◽

...

Keyword(s):

Colorectal Cancer ◽

Porous Silicon ◽

Anticancer Therapy ◽

Ph Sensitive ◽

Ph Responsive ◽

Ph Sensitive Polymer ◽

Bacterial Nanowires

Drug loaded luminescent porous silicon diatoms and magnetic bacterial nanowires were encapsulated within pH sensitive polymer forming biodegradable microcapsules using droplet-based microfluidics for targeting colorectal cancer.

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pH-Responsive prodrug nanoparticles based on a sodium alginate derivative for selective co-release of doxorubicin and curcumin into tumor cells

Nanoscale ◽

10.1039/c7nr03611f ◽

2017 ◽

Vol 9 (34) ◽

pp. 12533-12542 ◽

Cited By ~ 52

Author(s):

Cheng Gao ◽

Fan Tang ◽

Guiyi Gong ◽

Jianxiang Zhang ◽

Maggie P. M. Hoi ◽

...

Keyword(s):

Cancer Cells ◽

Tumor Cells ◽

Sodium Alginate ◽

Safety Profile ◽

Ph Sensitive ◽

Efficacy And Safety ◽

Ph Responsive

A pH-sensitive prodrug nanoparticle demonstrated the selective co-delivery of doxorubicin and curcumin into cancer cells with much improved efficacy and safety profile.

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pH-responsive polymer in a core–shell magnetic structure as an efficient carrier for delivery of doxorubicin to tumor cells

International Journal of Polymeric Materials ◽

10.1080/00914037.2017.1405348 ◽

2017 ◽

Vol 67 (16) ◽

pp. 967-977 ◽

Cited By ~ 6

Author(s):

Farzaaneh Zaaeri ◽

Mehdi Khoobi ◽

Mohammadreza Rouini ◽

Hamid Akbari Javar

Keyword(s):

Magnetic Structure ◽

Tumor Cells ◽

Core Shell ◽

Ph Responsive ◽

Responsive Polymer

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Stabilization and Release of Palm Tocotrienol Emulsion Fabricated Using pH-Sensitive Calcium Carbonate

Foods ◽

10.3390/foods10020358 ◽

2021 ◽

Vol 10 (2) ◽

pp. 358

Author(s):

Phui Yee Tan ◽

Beng Ti Tey ◽

Eng Seng Chan ◽

Oi Ming Lai ◽

Hon Weng Chang ◽

...

Keyword(s):

Calcium Carbonate ◽

Droplet Size ◽

Entrapment Efficiency ◽

Ph Sensitive ◽

Emulsion System ◽

Ph Responsive ◽

Small Droplet ◽

Homogenization Time ◽

Oil In Water ◽

Ph Range

Calcium carbonate (CaCO3) has been utilized as a pH-responsive component in various products. In this present work, palm tocotrienols-rich fraction (TRF) was successfully entrapped in a self-assembled oil-in-water (O/W) emulsion system by using CaCO3 as the stabilizer. The emulsion droplet size, viscosity and tocotrienols entrapment efficiency (EE) were strongly affected by varying the processing (homogenization speed and time) and formulation (CaCO3 and TRF concentrations) parameters. Our findings indicated that the combination of 5000 rpm homogenization speed, 15 min homogenization time, 0.75% CaCO3 concentration and 2% TRF concentration resulted in a high EE of tocotrienols (92.59–99.16%) and small droplet size (18.83 ± 1.36 µm). The resulting emulsion system readily released the entrapped tocotrienols across the pH range tested (pH 1–9); with relatively the highest release observed at pH 3. The current study presents a potential pH-sensitive emulsion system for the entrapment and delivery of palm tocotrienols.

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