Development and Application of a Biorelevant Dissolution Method Using USP Apparatus 4 in Early Phase Formulation Development

2010 ◽  
Vol 7 (5) ◽  
pp. 1466-1477 ◽  
Author(s):  
Jiang B. Fang ◽  
Vivian K. Robertson ◽  
Archana Rawat ◽  
Tawnya Flick ◽  
Zhe J. Tang ◽  
...  
Keyword(s):  
Early Phase ◽  
Formulation Development ◽  
Dissolution Method ◽  
Biorelevant Dissolution ◽  
Usp Apparatus 4 ◽  
Usp Apparatus

USP Apparatus 4: a Valuable In Vitro Tool to Enable Formulation Development of Long-Acting Parenteral (LAP) Nanosuspension Formulations of Poorly Water-Soluble Compounds

2017 ◽  
Vol 19 (1) ◽  
pp. 413-424 ◽  
Author(s):  
William P. Forrest ◽  
Kevin G. Reuter ◽  
Vivek Shah ◽  
Irina Kazakevich ◽  
Michael Heslinga ◽  
...  
Keyword(s):  
Water Soluble ◽  
Formulation Development ◽  
Usp Apparatus 4 ◽  
Poorly Water Soluble ◽  
Long Acting ◽  
Usp Apparatus

Validation of USP apparatus 4 method for microsphere in vitro release testing using Risperdal® Consta®

2011 ◽  
Vol 420 (2) ◽  
pp. 198-205 ◽  
Author(s):  
Archana Rawat ◽  
Erika Stippler ◽  
Vinod P. Shah ◽  
Diane J. Burgess
Keyword(s):  
In Vitro Release ◽  
Usp Apparatus 4 ◽  
Usp Apparatus ◽  
Vitro Release ◽  
Release Testing

scholarly journals USP Apparatus 4 (Flow-Through Method) Primer

1996 ◽  
Vol 3 (4) ◽  
pp. 10-12 ◽  
Author(s):  
Terry J. Looney
Keyword(s):  
Flow Through ◽  
Usp Apparatus 4 ◽  
Usp Apparatus

scholarly journals Simultaneous Sampling and HPLC Injection from USP Apparatus 4 using a Dual Sampling Rack

2005 ◽  
Vol 12 (2) ◽  
pp. 44-45
Author(s):  
Dr. Andrew Hodson ◽  
Keith A. Wilkinson
Keyword(s):  
Usp Apparatus 4 ◽  
Usp Apparatus

scholarly journals Development of USP Apparatus 3 Dissolution Method with IVIVC for Extended Release Tablets of Metformin Hydrochloride and Development of a Generic Formulation

2019 ◽  
Vol 67 (1) ◽  
pp. 23-31
Author(s):  
Thamara de Carvalho Mendes ◽  
Alice Simon ◽  
Jaqueline Correia Villaça Menezes ◽  
Eduardo Costa Pinto ◽  
Lucio Mendes Cabral ◽  
...  
Keyword(s):  
Extended Release ◽  
Metformin Hydrochloride ◽  
Dissolution Method ◽  
Apparatus 3 ◽  
Usp Apparatus

scholarly journals Study of Release-Retardant Polymers in Formulation Development of Cinnarizine-HCl Sustained-release Oral Suspension Using Raft Technology

2020 ◽  
Vol 19 (1) ◽  
pp. 14-24
Author(s):  
Tabinda Islam ◽  
Nusrat Hossain ◽  
Mohsina Rahman ◽  
Sadia Shabnam ◽  
Eyasmin Chowdhury ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Vitro Dissolution ◽  
Formulation Development ◽  
Hydrochloric Acid Medium ◽  
Sodium Saccharin ◽  
Physical Mixing ◽  
Mixing Method ◽  
Usp Apparatus

The main objective of this research was to develop a sustained-release suspension of cinnarizine hydrochloride using raft-forming technique. This innovative approach has been utilized to formulate a series of suspension formulations using hydroxypropyl cellulose (HPC) as a release-retardant polymeric agent. Cinnarizine sustained-release suspensions were prepared by physical mixing method with varying concentrations and combinations of HPC, sodium citrate, sodium saccharin, calcium carbonate, sodium alginate, methyl hydroxybenzoate and propyl hydroxybenzoate. The formulations were subjected for determination of floating time, floating lag time, weight of the raft, physical appearance and in-vitro dissolution. The dissolution was conducted through USP apparatus 2 (paddle type) in 0.1N hydrochloric acid medium having pH 1.2. The key findings of the study demonstrate that a stable sustained-release suspension of cinnarizine can be formulated using raft-forming approach for increased bioavailability and patient-convenience. Dhaka Univ. J. Pharm. Sci. 19(1): 15-24, 2020 (June)

DISSOLUTION METHOD DEVELOPMENT AND VALIDATION OF TRAMADOL HYDROCHLORIDE CAPSULES

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (08) ◽  
pp. 47-50
Author(s):  
H Farheen ◽  
◽  
T Mamatha . ◽  
Z Yasmeen ◽  
Rao J. Venkateswara
Keyword(s):  
Method Development ◽  
Estimation Method ◽  
Dissolution Behavior ◽  
Official Method ◽  
Dissolution Medium ◽  
Tramadol Hydrochloride ◽  
Dissolution Method ◽  
Ich Guidelines ◽  
Development And Validation ◽  
Usp Apparatus

A dissolution method was developed and validated for evaluation of the dissolution behavior of capsule dosage form of tramadol hydrochloride as there was no official method available. The UV spectrophotometric method developed was based on the direct estimation method using 271 nm as λmax of tramadol hydrochloride. The method was validated according to International Conference on Harmonisation (ICH) guidelines which include accuracy, precision, specificity, linearity, and analytical range. In addition, solubility and stability of the drug in dissolution medium i.e., 0.1 N HCl was studied. The established dissolution conditions were 900 mL dissolution medium at temperature 37 ± 0.5°C, using USP apparatus I at stirring rate of 100 rpm for 30 min. The corresponding dissolution profiles were constructed and all the selected brands showed more than 80% drug release with in 30 min. Thus, the proposed dissolution method can be applied successfully for the quality control of tramadol hydrochloride capsules.

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