Microbial Transformation of Isosteviol Lactone and Evaluation of the Transformation Products on Androgen Response Element

2008 ◽  
Vol 71 (4) ◽  
pp. 602-607 ◽  
Author(s):  
Bo-Hon Chou ◽  
Li-Ming Yang ◽  
Shwu-Fen Chang ◽  
Feng-Lin Hsu ◽  
Chia-Hsin Lo ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Transformation Products ◽  
Response Element ◽  
Androgen Response Element

Functional characterization of an androgen response element

1990 ◽  
Vol 18 (4) ◽  
pp. 561-562 ◽  
Author(s):  
F. CLAESSENS ◽  
N. RUSHMERE ◽  
L. CELIS ◽  
B. PEETERS ◽  
P. DAVIES ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Response Element ◽  
Androgen Response Element

scholarly journals Effects of G/A polymorphism, rs266882, in the androgen response element 1 of the PSA gene on prostate cancer risk, survival and circulating PSA levels

2008 ◽  
Vol 99 (10) ◽  
pp. 1743-1747 ◽  
Author(s):  
C Jesser ◽  
L Mucci ◽  
D Farmer ◽  
C Moon ◽  
H Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Response Element ◽  
Androgen Response Element

scholarly journals Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element

2013 ◽  
Vol 27 (12) ◽  
pp. 2028-2040 ◽  
Author(s):  
Liesbeth Clinckemalie ◽  
Lien Spans ◽  
Vanessa Dubois ◽  
Michaël Laurent ◽  
Christine Helsen ◽  
...  
Keyword(s):  
Response Element ◽  
Androgen Response Element ◽  
Androgen Regulation

scholarly journals Further evidence for the importance of an androgen response element in the factor IX promoter

1997 ◽  
Vol 98 (1) ◽  
pp. 79-85 ◽  
Author(s):  
GARETH E. MORGAN ◽  
GABRIELLA ROWLEY ◽  
PETER M. GREEN ◽  
MORAG CHISHOLM ◽  
FRANCESCO GIANNELLI ◽  
...  
Keyword(s):  
Factor Ix ◽  
Response Element ◽  
Androgen Response Element

High-Throughput Identification of Microbial Transformation Products of Organic Micropollutants

2010 ◽  
Vol 44 (17) ◽  
pp. 6621-6627 ◽  
Author(s):  
Damian E. Helbling ◽  
Juliane Hollender ◽  
Hans-Peter E. Kohler ◽  
Heinz Singer ◽  
Kathrin Fenner
Keyword(s):  
High Throughput ◽  
Microbial Transformation ◽  
Transformation Products ◽  
Organic Micropollutants

Abstract 4984: Androgen response element of the glycine N-methyltransferase gene is located in first intron

2010 ◽  
Author(s):  
Cheng-Ming Lee ◽  
Chia-Hung Yen ◽  
Yi-Ming A. Chen
Keyword(s):  
Response Element ◽  
Androgen Response Element ◽  
First Intron ◽  
Methyltransferase Gene

Microbial Transformations of Azaarenes in Creosote-Contaminated Soil and Ground Water: Laboratory and Field Studies

1988 ◽  
Vol 20 (11-12) ◽  
pp. 17-23 ◽  
Author(s):  
Wilfred E. Pereira ◽  
Colleen E. Rostad ◽  
David M. Updegraff ◽  
Jon L. Bennett
Keyword(s):  
Ground Water ◽  
Contaminated Soil ◽  
Isotope Labeling ◽  
Microbial Transformation ◽  
Wood Preservative ◽  
Transformation Products ◽  
Gas Chromatography Mass Spectrometry ◽  
Experimental Conditions ◽  
Hydroxylation Reaction ◽  
Contaminated Aquifers

Azaarenes or aromatic nitrogen heterocycles are a class of compounds found in wood-preservative wastes containing creosote. The fate and movement of these compounds in contaminated aquifers is not well understood. Water-quality studies in an aquifer contaminated with creosote near Pensacola, Florida, indicated that ground water was contaminated with several azaarenes and their oxygenated and alkylated derivatives, suggesting that these oxygenated compounds may be products of microbial transformation reactions. Accordingly, laboratory studies were designed to investigate the fate of these compounds. Under aerobic conditions, soil pseudomonads isolated from creosote-contaminated soil converted quinoline to 2(lH)quinolinone that subsequently was degraded to unknown products. A methanogenic consortium isolated from an anaerobic sewage digestor, in presence of ground-water and creosote-contaminated soil, converted quinoline, isoquinoline, and 4-methylquinoline to their respective oxygenated analogs. In addition, N-, C-, and O-methylated analogs of oxygenated azaarenes were identified by gas chromatography-mass spectrometry (GC-MS) in anaerobic cultures. Under the experimental conditions, 2-methylquinoline was biorefractory. Presence of similar biotransformation products in anaerobic cultures and contaminated ground water from the Pensacola site provided further evidence that these compounds indeed were microbial transformation products. Stable isotope labeling studies indicated that the source of the oxygen atom for this hydroxylation reaction under aerobic and anaerobic conditions was water. A mechanism was proposed for this hydroxylation reaction. Whereas parent azaarenes are biodegradable in both anaerobic and aerobic zones, oxygenated and alkylated analogs are more biorefractory and, hence, persistent in anaerobic zones of contaminated aquifers.

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