scholarly journals InVitroExpression Levels of Cell-Cycle Checkpoint Proteins Are Associated with Cellular DNA Repair Capacity in Peripheral Blood Lymphocytes:  A Multivariate Analysis

2007 ◽  
Vol 6 (4) ◽  
pp. 1560-1567 ◽  
Author(s):  
You-Hong Fan ◽  
Zhibin Hu ◽  
Chunying Li ◽  
Li-E Wang ◽  
Zhaozheng Guo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Multivariate Analysis ◽  
Peripheral Blood Lymphocytes ◽  
Cell Cycle Checkpoint ◽  
Repair Capacity ◽  
Checkpoint Proteins ◽  
Dna Repair Capacity ◽  
Cycle Checkpoint ◽  
Cellular Dna

scholarly journals The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 479
Author(s):  
Pavel Vodicka ◽  
Ladislav Andera ◽  
Alena Opattova ◽  
Ludmila Vodickova
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Repair ◽  
Dna Lesions ◽  
Cell Cycle Checkpoint ◽  
Solid Cancer ◽  
Genomic Integrity ◽  
Repair Capacity ◽  
Mutational Status ◽  
Telomere Homeostasis

The disruption of genomic integrity due to the accumulation of various kinds of DNA damage, deficient DNA repair capacity, and telomere shortening constitute the hallmarks of malignant diseases. DNA damage response (DDR) is a signaling network to process DNA damage with importance for both cancer development and chemotherapy outcome. DDR represents the complex events that detect DNA lesions and activate signaling networks (cell cycle checkpoint induction, DNA repair, and induction of cell death). TP53, the guardian of the genome, governs the cell response, resulting in cell cycle arrest, DNA damage repair, apoptosis, and senescence. The mutational status of TP53 has an impact on DDR, and somatic mutations in this gene represent one of the critical events in human carcinogenesis. Telomere dysfunction in cells that lack p53-mediated surveillance of genomic integrity along with the involvement of DNA repair in telomeric DNA regions leads to genomic instability. While the role of individual players (DDR, telomere homeostasis, and TP53) in human cancers has attracted attention for some time, there is insufficient understanding of the interactions between these pathways. Since solid cancer is a complex and multifactorial disease with considerable inter- and intra-tumor heterogeneity, we mainly dedicated this review to the interactions of DNA repair, telomere homeostasis, and TP53 mutational status, in relation to (a) cancer risk, (b) cancer progression, and (c) cancer therapy.

scholarly journals DNA repair and cell cycle checkpoint defects in a mouse model of ‘BRCAness’ are partially rescued by 53BP1 deletion

Cell Cycle ◽  
2018 ◽  
Vol 17 (7) ◽  
pp. 881-891 ◽  
Author(s):  
Sarah M. Misenko ◽  
Dharm S. Patel ◽  
Joonyoung Her ◽  
Samuel F. Bunting
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Mouse Model ◽  
Cell Cycle Checkpoint ◽  
Cycle Checkpoint

Convergence of DNA repair and cell-cycle checkpoint control

2000 ◽  
Vol 2 (6) ◽  
pp. E95-E95 ◽  
Author(s):  
Angela Eggleston
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Control ◽  
Cycle Checkpoint

scholarly journals ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107142 ◽  
Author(s):  
Erhong Meng ◽  
Aparna Mitra ◽  
Kaushlendra Tripathi ◽  
Michael A. Finan ◽  
Jennifer Scalici ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Dna Repair ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Cycle Checkpoint ◽  
Cycle Checkpoint ◽  
Altered Regulation ◽  
Regulation Of Cell Cycle

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

1997 ◽  
Vol 11 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Peer Bork ◽  
Kay Hofmann ◽  
Philipp Bucher ◽  
Andrew F. Neuwald ◽  
Stephen F. Altschul ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Checkpoint ◽  
Conserved Domains ◽  
Checkpoint Proteins ◽  
Cycle Checkpoint ◽  
Responsive Cell
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