Hypothesis: the act of taking a Papanicolaou smear reduces the prevalence of human papillomavirus infection: a potential impact on the risk of cervical cancer

2003 ◽  
Vol 14 (10) ◽  
pp. 953-957 ◽  
Author(s):  
Samuel Shapiro ◽  
Henri Carrara ◽  
Bruce R. Allan ◽  
Margaret Hoffman ◽  
Lynn Rosenberg ◽  
...  
Sexual Health ◽  
2010 ◽  
Vol 7 (3) ◽  
pp. 368 ◽  
Author(s):  
David G. Regan ◽  
David J. Philp ◽  
Edward K. Waters

Mathematical transmission models are widely used to forecast the potential impact of interventions such as vaccination and to inform the development of health policy. Effective vaccines are now available for the prevention of cervical cancer and other diseases attributable to human papillomavirus (HPV). Considerable uncertainties remain regarding the characterisation of HPV infection and its sequelae, infectivity, and both vaccine-conferred and naturally-acquired immunity. In this review, we discuss the key knowledge gaps that impact on our ability to develop accurate models of HPV transmission and vaccination.


Author(s):  
Jacqueline M. Mills ◽  
Elizabeth A. Stier

In 1992 Lorincz et al. were the first to evaluate the clinicopathologic correlation with 11 recently identified human papillomavirus (HPV) genotypes: 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, and 58. Using cervical samples from 8 studies that included specimens from 2627 women, HPV genotypes were categorized by the likelihood of association with grades of cervical neoplasia (from normal to cancer). These findings were the basis of the determination that (a) HPV causes cervical cancer, (b) detection of the cancer associated HPV genotypes could identify women at risk for cervical pre-cancer and cancer, and (c) a prophylactic HPV vaccine should include protection against (at least) HPV 16 and 18.


Apmis ◽  
1994 ◽  
Vol 102 (1-6) ◽  
pp. 122-128 ◽  
Author(s):  
EWY Kristiansen ◽  
ANDREW Jenkins ◽  
GUNNAR Kristensen ◽  
EIRIK Ask ◽  
JANNE KaeRn ◽  
...  

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