Molecular Basis of Anti-Apoptotic Effect of Immunophilin Ligands on Hydrogen Peroxide–Induced Apoptosis in Human Glioma Cells

2004 ◽  
Vol 29 (8) ◽  
pp. 1529-1536 ◽  
Author(s):  
Ken-ichi Tanaka ◽  
Masato Asanuma ◽  
Norio Ogawa
Keyword(s):  
Hydrogen Peroxide ◽  
Molecular Basis ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Apoptotic Effect ◽  
Induced Apoptosis

scholarly journals Inhibition of cell proliferation by 2-fluorobenzaldehyde retinoic acid conjugate through suppression of STAT3 activation in human glioma cells

2015 ◽  
Vol 10 (4) ◽  
pp. 966
Author(s):  
Ji-Heng Hao ◽  
Dian-Feng Hu ◽  
Li-Mei Mao ◽  
Shi-Gang Zhang ◽  
Ji-Yue Wang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Glioma Cells ◽  
Inhibitory Effect ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Expression Of Genes ◽  
Acid Conjugate ◽  
G0 Phase ◽  
Induced Apoptosis ◽  
Endothelial Growth Factor

<p class="Abstract">The present study was performed to investigate the effect of 2-fluorobenzaldehyde retinoic acid conjugate on activation of STAT3 pathway in human glioma cells. The results revealed that the compound exhibited inhibitory effect on the activation of STAT3 induced constitutively and by interleukin-6. The inhibitory effect on STAT3 activation was found to be concentration- and time-dependent. In U373 glioma cells, 2-fluorobenzaldehyde retinoic acid conjugate treatment caused a significant enhancement in the expression of proapoptotic proteins like Bax and Bak. Its treatment inhibited the expression of genes including, cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor (VEGF) in U373 glioma cells. Furthermore, the conjugate inhibited proliferation, induced apoptosis and caused accumulation of cells in G1-G0 phase of cell cycle. Thus, 2-fluorobenzaldehyde retinoic acid conjugate acts as a potent inhibitor of STAT3 activation that can be promising importance for the prevention and treatment of gliomas.</p><p> </p>

scholarly journals Mig-2 attenuates cisplatin-induced apoptosis of human glioma cells in vitro through AKT/JNK and AKT/p38 signaling pathways

2014 ◽  
Vol 35 (9) ◽  
pp. 1199-1206 ◽  
Author(s):  
Yun-wei Ou ◽  
Zi-tong Zhao ◽  
Chuan-yue Wu ◽  
Bai-nan Xu ◽  
Yong-mei Song ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis

scholarly journals Sensitization to CD95 ligand-induced apoptosis in human glioma cells by hyperthermia involves enhanced cytochrome c release

Oncogene ◽  
2000 ◽  
Vol 19 (19) ◽  
pp. 2338-2345 ◽  
Author(s):  
Mirjam Hermisson ◽  
Bettina Wagenknecht ◽  
Hartwig Wolburg ◽  
Tamara Glaser ◽  
Johannes Dichgans ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Cytochrome C Release ◽  
Cd95 Ligand ◽  
Induced Apoptosis

scholarly journals Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

FEBS Letters ◽  
2010 ◽  
Vol 584 (16) ◽  
pp. 3519-3524 ◽  
Author(s):  
Ting-Kuang Niu ◽  
Yan Cheng ◽  
Xingcong Ren ◽  
Jin-Ming Yang
Keyword(s):  
Glioma Cells ◽  
Beclin 1 ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis

Role of ERK in Hydrogen Peroxide-Induced Cell Death of Human Glioma Cells

2005 ◽  
Vol 30 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Won Chang Lee ◽  
Chang Hwa Choi ◽  
Seung Heon Cha ◽  
Hyun Lim Oh ◽  
Yong Keun Kim
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells

Two Different Mechanisms of Apoptosis Resistance Observed in Interferon-  Induced Apoptosis of Human Glioma Cells

2004 ◽  
Vol 67 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Ryuta Saito ◽  
Masaaki Mizuno ◽  
Manabu Hatano ◽  
Toshihiro Kumabe ◽  
Takashi Yoshimoto ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Apoptosis Resistance ◽  
Induced Apoptosis

scholarly journals Migfilin sensitizes cisplatin-induced apoptosis in human glioma cells in vitro

2012 ◽  
Vol 33 (10) ◽  
pp. 1301-1310 ◽  
Author(s):  
Jing Fan ◽  
Yun-wei Ou ◽  
Chuan-yue Wu ◽  
Chun-jiang Yu ◽  
Yong-mei Song ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis

scholarly journals p53-Independent ceramide formation in human glioma cells during γ-radiation-induced apoptosis

2004 ◽  
Vol 11 (8) ◽  
pp. 853-861 ◽  
Author(s):  
S Hara ◽  
S Nakashima ◽  
T Kiyono ◽  
M Sawada ◽  
S Yoshimura ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Γ Radiation ◽  
Radiation Induced ◽  
Induced Apoptosis

scholarly journals Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation

2011 ◽  
Vol 13 (3) ◽  
pp. 267-279 ◽  
Author(s):  
In Young Kim ◽  
You Jung Kang ◽  
Mi Jin Yoon ◽  
Eun Hee Kim ◽  
Seung U Kim ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis
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