Nutrient Supplementation as Adjunct Therapy in Pulmonary Tuberculosis

2004 ◽  
Vol 74 (2) ◽  
pp. 144-146 ◽  
Author(s):  
Chandra

The study examined the effect of supplementation with multivitamins and trace elements on microbiological and radiological recovery in patients with pulmonary tuberculosis. Forty-four patients aged 28–50 years were diagnosed with active pulmonary tuberculosis based on X-ray of the chest and smear examination of the sputum for the presence of acid-fast bacilli. They were all treated for six months with a standard anti-tuberculosis regimen that has been found to be effective worldwide for disease control. The subjects were randomized to receive either a multivitamin-trace element supplement or a placebo containing calcium. The two groups were matched on all relevant confounding variables. At two months into the treatment, the group that was supplemented with a multivitamin-trace element preparation showed a significant reduction in the number of individuals with sputum smear positive for acid-fast bacillus: two out of 22 individuals, compared with seven out of 22 among placebo-treated controls (p = 0.028, Fisher’s test). It is concluded that patients with tuberculosis should be supplemented with a suitable micronutrient preparation that contains optimum amounts of all vitamins and trace elements that have been documented to enhance the immune response.

Author(s):  
Islam Mejri Ep Ajili ◽  
Soumaya Ben Saad ◽  
Achref Ben Tkhayet ◽  
Hafaoua Daghfous ◽  
Fatma Tritar

2017 ◽  
Vol 24 (34) ◽  
pp. 26513-26520 ◽  
Author(s):  
Zainab Manzoor Memon ◽  
Erkan Yilmaz ◽  
Afsheen Mushtaque Shah ◽  
Ugur Sahin ◽  
Tasneem Gul Kazi ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Pooja Prasad ◽  
Minakshi Bhardwaj

Tuberculosis is one of the major causes of ill health and death worldwide. Isolated tuberculosis of tonsil in the absence of active pulmonary tuberculosis is a very rare clinical entity. A 10-year-male child presented with recurrent episodes of upper respiratory tract infections, with 2-3 occurrences per month for the past 6 years. On general physical examination, bilateral tonsils showed grade III enlargement and congestion. Posterior pharyngeal wall was clear. Examination of the chest was within normal limits. Histopathological examination of bilateral tonsils revealed caseating and noncaseating epithelioid cell granulomas with Langhans giant cells. Ziehl-Neelsen stain for acid fast bacillus was positive. Features were consistent with a diagnosis of tuberculosis of tonsils. Tuberculosis of the oral cavity is uncommon and lesions may be either primary or secondary. Early detection and intervention is essential for cure. Isolated and primary tuberculosis of the tonsils in the absence of pulmonary tuberculosis is a rare entity, which prompted us to report this case.


2005 ◽  
Vol 99 (4) ◽  
pp. 415-420 ◽  
Author(s):  
A.T. Abal ◽  
B. Jayakrishnan ◽  
S. Parwer ◽  
A. El Shamy ◽  
E. Abahussain ◽  
...  

2008 ◽  
Vol 15 (6) ◽  
pp. 1028-1030 ◽  
Author(s):  
Kelly Aparecida Kanunfre ◽  
Olavo Henrique Munhoz Leite ◽  
Max Igor Lopes ◽  
Marcelo Litvoc ◽  
Antonio Walter Ferreira

ABSTRACT This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to ≥0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test.


2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Francioli Koro Koro ◽  
Alphonse Um Boock ◽  
Afi Leslie Kaiyven ◽  
Juergen Noeske ◽  
Cristina Gutierrez ◽  
...  

Background. Cameroon this last decade continues to present a low contribution ofM. africanumandM. bovisin human tuberculosis (TB), whileM. boviswas prevalent in cattle but all these pieces of information only concerned West and Center regions.Methods. We carried out the first study in Adamaoua, one of the most rearing regions of Cameroon, on the genetic structure and drug susceptibility of the MTBC strains isolated from newly diagnosed sputum smear-positive patients aged 15 years and above. For that purpose, spoligotyping, a modified 15 standard MIRU/VNTR loci typing, and the proportion method were used.Results. Four hundred and thirty-seven MTBC isolates were analyzed by spoligotyping. Of these, 423 were identified asM. tuberculosis, within the Cameroon family being dominant with 278 (65.7%) isolates; twelve (2.75%) isolates were classified asM. africanumand two asM. bovis. MIRU/VNTR typing of the most prevalent sublineage (SIT 61) suggested that this lineage is not a unique clone as thought earlier but could constitute a group of strains implicated to different pocket of TB transmission. OnlyM. tuberculosissublineages were associated with antituberculosis drug resistance.Conclusion. These results showed the weak contribution ofM. africanumandM. bovisto human active pulmonary tuberculosis in Cameroon even in the rearing region.


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