Influence of dorzolamide on corneal thickness, endothelial cell count and corneal sensibility

1998 ◽  
Vol 76 (1) ◽  
pp. 78-79 ◽  
Author(s):  
Stephan Kaminski ◽  
Anton Hommer ◽  
Didem Koyuncu ◽  
Robert Biowski ◽  
Talin Barisani ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Count ◽  
Corneal Thickness ◽  
Endothelial Cell Count

scholarly journals A Comparative Study of Corneal Endothelial Cell Count and Central Corneal Thickness in Emmetropia and Axial Myopia

2020 ◽  
Vol 9 (44) ◽  
pp. 3300-3304
Author(s):  
Vandana Panjwani ◽  
Sachin Daigavane
Keyword(s):  
Endothelial Cell ◽  
Comparative Study ◽  
Cell Count ◽  
Axial Length ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Corneal Endothelial Cell ◽  
Specular Microscopy ◽  
Endothelial Cell Count ◽  
Axial Myopia

BACKGROUND The main attributes of cornea which makes it optically important is its ability to maintain its dehydrated state. This corneal dehydration can be achieved and maintained by various factors among which corneal endothelial cell count and morphology play a significant role. Corneal attributes considered in this study i.e. the corneal endothelial cell count and central corneal thickness are extremely variable, and changes are seen even with smaller changes in anterior segment or overall structural changes in eyes. We wanted to compare central corneal thickness in emmetropia and axial myopia and compare corneal endothelial cell count in emmetropia and axial myopia. METHODS The sample size was decided taking into consideration various prevalence studies. The patients were consecutively recruited for the study considering the inclusion and exclusion criteria. The subjects were divided into two groups emmetropia and axial myopia and were differentiated on the basis of the axial lengths. Specular microscopy was performed for the subjects and corneal endothelial cell count, morphology and central corneal thickness were measured, and comparative study was performed. RESULTS This study of 80 eyes shows us that the difference between mean the corneal endothelial cell count between emmetrope (2812.80 cells / mm2) and axial myopes (2653 cells / mm2) is statistically significant where p was < 0.05 while the mean central corneal thickness measurements didn’t show statistically significant change between emmetrope (490.05 microns) and axial myope. (489.37 microns). CONCLUSIONS Axial length has an indirect correlation with the corneal endothelial cell count which is statistically significant. While significant correlation between the central corneal thickness and axial length cannot be established in this study. KEY WORDS Emmetropia, Axial Myopia, Corneal Endothelial Cell Count, Central Corneal Thickness, Comparison

The utility of contact lens-assisted corneal cross-linking (CACXL) in progressive keratoconus patients with thin corneas

2022 ◽  
pp. 112067212110709
Author(s):  
Bilgehan Sezgin Asena ◽  
Mahmut Kaskaloglu
Keyword(s):  
Visual Acuity ◽  
Endothelial Cell ◽  
Cell Count ◽  
Contact Lens ◽  
Corneal Thickness ◽  
Hydroxypropyl Methylcellulose ◽  
Cross Linking ◽  
Demarcation Line ◽  
Endothelial Cell Count ◽  
The Mean

Purpose To evaluate efficacy and safety of contact lens-assisted corneal cross-linking (CACXL) among progressive keratoconus patients with thin corneas. Setting Private eye hospital Design Cross-sectional study Methods Thirty-six eyes of 36 consecutive patients with progressive keratoconus and thinnest corneal thickness of 380–400 µm after epithelium removal were included. CACXL was performed based on use of a dextran-free isotonic (>0.1%) riboflavin solution with hydroxypropyl methylcellulose (HPMC, 1.1%) after epithelial removal and placement of a riboflavin-soaked contact lens without an ultraviolet filter on the cornea and ultraviolet irradiance. Data on best distance corrected (CDVA) and uncorrected (UDVA) visual acuity, manifest sphere (D), manifest cylinder (D), K1 (D), K2 (D), mean keratometry (D) and Kmax (D) values, endothelial cell count and mean depth of demarcation line were recorded preoperatively and at the postoperative 1-year Results Post-operative 1-year data revealed significant increases in UDVA (0.23  ±  0.15 vs. 0.17  ±  0.13 D, p < 0.001) and CDVA (0.44  ±  0.18 vs. 0.36  ±  0.17 D, p < 0.001) values and a significant reduction in the mean Kmax (from 56  ±  3.3D to 55  ±  3.2 D, p < 0.001), K2 (from 49.7  ±  3.2 D to 49.52  ±  3.11 D, p  =  0.049), manifest sphere (from −1.93  ±  2.21 D to −1.55  ±  2.02 D, p  =  0.001) and manifest cylinder (from −2.83  ±  1.67 D to −2.39  ±  1.36 D, p < 0.001) values along with a similar endothelial cell count. The mean depth of demarcation line was mean 230 (SD17.05, range 200 to 262) at postoperative 1-month. Conclusions Our findings indicate favourable 1-year postoperative outcome of CACXL in progressive keratoconus patients with thin cornea in terms of improved visual acuity and keratectasia status as well as endothelial safety.

Changes in Central Corneal Thickness and Endothelial Cell Count after Lasik

2017 ◽  
Vol 19 (3) ◽  
pp. 1-8
Author(s):  
Syed Kubravi ◽  
Syed Qureshi ◽  
Shah Nawaz ◽  
Arshi Nazir ◽  
Khalid Kawoosa
Keyword(s):  
Endothelial Cell ◽  
Cell Count ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Endothelial Cell Count

scholarly journals Clinical performance of presbyopia correction with a multifocal corneoscleral lens

2021 ◽  
Vol 14 (4) ◽  
pp. 529-535
Author(s):  
Woo Chan Park ◽  
◽  
Sang Wook Jin ◽  
Keyword(s):  
Endothelial Cell ◽  
Cell Count ◽  
Clinical Performance ◽  
Corneal Thickness ◽  
Corneal Edema ◽  
Corneal Endothelial Cell ◽  
Conjunctival Hyperemia ◽  
Endothelial Cell Count ◽  
Corneal Staining ◽  
Presbyopia Correction

AIM: To assess the clinical performance of a multifocal corneoscleral lens for the presbyopia correction. METHODS: A prospective clinical trial of the Onefit™ A multifocal corneoscleral lens was conducted with 40 participants with presbyopia. At 4wk of continuous wear of the corneoscleral lens, changes in the distance, intermediate, and near visual acuity (VA) were evaluated. The safety of the corneoscleral lens, central corneal thickness (CCT), corneal endothelial cell count, binocular stereopsis, tear film break-up time (BUT), corneal staining, corneal edema, corneal neovascularization (NV), and conjunctival hyperemia were examined. In addition, a subjective questionnaire addressing satisfaction (rated from 1 to 5 points) and discomfort (rated from 1 to 5 points) was administered. RESULTS: Forty participants were enrolled in this study. Six participants were excluded because of poor compliance with lens fitting (n=2) and loss to follow-up (n=4). The mean age of the participants was 53.0±4.9y. At 4wk of continuous wear of the corneoscleral lens, the best corrected far, intermediate, and near VA was 0.08±0.11, 0.10±0.12, and 0.10±0.12 logMAR, respectively. These results were significant improvements over the baseline uncorrected VA (far: P=0.004; intermediate: P=0.004; near: P=0.002). CCT, corneal endothelial cell count, binocular stereopsis, BUT, corneal staining, corneal edema, corneal NV, and conjunctival hyperemia were not significantly different between baseline and after corneoscleral lens use. The average satisfaction scores for fit sensation; corrected far, intermediate, and near VA; and ease of handling were 4.1, 3.4, 3.6, 3.5, and 3.4, respectively. The average discomfort scores for dryness, irritation, foreign body sensation, redness, fogging, and halo were 1.7, 1.8, 1.5, 1.7, 1.7, and 1.3, respectively. CONCLUSION: Far, intermediate, and near VA are improved in presbyopic patients with the multifocal corneoscleral lens compared to uncorrected baseline VA, without adverse ocular effects. This evidence supports the safety and effectiveness of presbyopia correction with multifocal corneoscleral lenses.

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