Membrane mimetic chemistry

AccessScience ◽  
2015 ◽  
Keyword(s):  
Membrane Mimetic

scholarly journals CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nathanael A. Caveney ◽  
Sean D. Workman ◽  
Rui Yan ◽  
Claire E. Atkinson ◽  
Zhiheng Yu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Acid Anhydride ◽  
Atomic Resolution ◽  
Inherent Difficulty ◽  
Penicillin Binding Proteins ◽  
Antibiotic Development ◽  
Class A ◽  
Membrane Mimetic ◽  
Antibacterial Target ◽  
Resolution Structure

AbstractThe pathway for the biosynthesis of the bacterial cell wall is one of the most prolific antibiotic targets, exemplified by the widespread use of β-lactam antibiotics. Despite this, our structural understanding of class A penicillin binding proteins, which perform the last two steps in this pathway, is incomplete due to the inherent difficulty in their crystallization and the complexity of their substrates. Here, we determine the near atomic resolution structure of the 83 kDa class A PBP from Escherichia coli, PBP1b, using cryogenic electron microscopy and a styrene maleic acid anhydride membrane mimetic. PBP1b, in its apo form, is seen to exhibit a distinct conformation in comparison to Moenomycin-bound crystal structures. The work herein paves the way for the use of cryoEM in structure-guided antibiotic development for this notoriously difficult to crystalize class of proteins and their complex substrates.

Dye-sensitized photo-oxidation of amino acids in reversed micellar membrane mimetic system

1997 ◽  
Vol 40 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Jianbo Liu ◽  
Fushi Zhang ◽  
Yu Zhao ◽  
Fuqun Zhao ◽  
Yingwu Tang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Photo Oxidation ◽  
Dye Sensitized ◽  
Membrane Mimetic

Hydrophobic forces are responsible for the folding of a highly potent natriuretic peptide analogue at a membrane mimetic surface: An NMR study

Biopolymers ◽  
1997 ◽  
Vol 42 (1) ◽  
pp. 37-48 ◽  
Author(s):  
Katharine A. Carpenter ◽  
Brian C. Wilkes ◽  
André De Léan ◽  
Alain Fournier ◽  
Peter W. Schiller
Keyword(s):  
Natriuretic Peptide ◽  
Peptide Analogue ◽  
Nmr Study ◽  
Membrane Mimetic
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