Olfactory dysfunction, gambling task performance and intracranial lesions after traumatic brain injury.

2010 ◽  
Vol 24 (4) ◽  
pp. 504-513 ◽  
Author(s):  
Solrun Sigurdardottir ◽  
Tone Jerstad ◽  
Nada Andelic ◽  
Cecilie Roe ◽  
Anne-Kristine Schanke

2017 ◽  
Vol 18 (1) ◽  
pp. 62-73 ◽  
Author(s):  
Anna-Lynne Ruth Adlam ◽  
Malcolm Adams ◽  
Oliver Turnbull ◽  
Giles Yeates ◽  
Fergus Gracey

The Bangor Gambling Task (BGT, Bowman & Turnbull, 2004) is a simple test of emotion-based decision making, with contingencies varying across five blocks of 20 trials. This is the first study to characterise BGT performance in survivors of traumatic brain injury (TBI) relative to healthy controls. The study also aimed to explore sub-groups (cluster analysis), and identify predictors of task performance (multiple regression). Thirty survivors of TBI and thirty-nine controls completed the BGT and measures of processing speed, pre-morbid IQ, working memory, and executive function. Results showed that survivors of TBI made more gamble choices than controls (total BGT score), although the groups did not significantly differ when using a cut-off score for ‘impaired’ performance. Unexpectedly, the groups did not significantly differ in their performance across the blocks; however, the cluster analysis revealed three subgroups (with survivors of TBI and controls represented in each cluster). Findings also indicated that only age and group were significant predictors of overall BGT performance. In conclusion, the study findings are consistent with an individual difference account of emotion-based decision making, and a number of issues need to be addressed prior to recommending the clinical use of the BGT.



2005 ◽  
Vol 18 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Brian Levine ◽  
Sandra E Black ◽  
Gordon Cheung ◽  
Ann Campbell ◽  
Colleen O??Toole ◽  
...  


1998 ◽  
Vol 79 (8) ◽  
pp. 888-892 ◽  
Author(s):  
Charles Christiansen ◽  
Beatriz Abreu ◽  
Kenneth Ottenbacher ◽  
Kenneth Huffman ◽  
Brent Masel ◽  
...  




2007 ◽  
Vol 8 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Melanie Drummond ◽  
Jacinta Douglas ◽  
John Olver

AbstractMost people only recognise the value of olfactory function after it is lost. In the context of traumatic brain injury with its far-reaching physical, cognitive, behavioural and emotional sequelae, posttraumatic olfactory dysfunction is an additional consequence that many survivors have to face as they adjust to a changed life situation. The aim of this article is to provide an update on posttraumatic anosmia for clinicians working in the area of brain injury rehabilitation. Brief reviews of incidence studies and causal mechanisms of olfactory impairment after brain injury are provided. Consequences of anosmia in the domains of safety, eating, personal hygiene, leisure, work and relationships with associated adaptive strategies are described.



Brain Injury ◽  
2018 ◽  
Vol 32 (8) ◽  
pp. 1021-1027 ◽  
Author(s):  
Mette Bratt ◽  
Toril Skandsen ◽  
Thomas Hummel ◽  
Kent G. Moen ◽  
Anne Vik ◽  
...  


Brain Injury ◽  
2010 ◽  
Vol 24 (6) ◽  
pp. 851-858 ◽  
Author(s):  
Jennifer A. Foley ◽  
Anna Cantagallo ◽  
Sergio Della Sala ◽  
Robert H. Logie


2019 ◽  
Vol 40 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Ning Gao ◽  
Xiaohui Zhang-Brotzge ◽  
Bushra Wali ◽  
Iqbal Sayeed ◽  
Joshua J Chern ◽  
...  

Traumatic brain injury (TBI) is the leading cause of death in children and adolescents in developed countries, but there are no blood-based biomarkers to support the diagnosis or prognosis of pediatric TBI to-date. Here we report that the plasma levels of osteopontin (OPN), a phosphoprotein chiefly secreted by macrophages and/or activated microglia, may contribute to this goal. In animal models of TBI, while OPN, fibrillary acidic protein (GFAP), and matrix metalloproteinase 9 (MMP-9) were all readily induced by controlled cortical impact in the brains of one-month-old mice, only OPN and GFAP ascended in the blood in correlation with high neurological severity scores (NSS). In children with TBI (three to nine years of age, n = 66), the plasma levels of OPN, but not GFAP, correlated with severe TBI (Glasgow Coma Score ≤ 8) and intracranial lesions at emergency department. In addition, the plasma OPN levels in severe pediatric TBI patients continued to ascend for 72 h and correlated with mortality and the days requiring ventilator or intensive care unit support, whereas the plasma GFAP levels lacked these properties. Together, these results suggest that plasma OPN outperforms GFAP and may be a neuroinflammation-based diagnostic and prognostic biomarker in pediatric TBI.



2021 ◽  
Vol 6 (1) ◽  
pp. 1352-1357
Author(s):  
Ajay Kumar Yadav ◽  
Binit Dev ◽  
Sushil Taparia ◽  
Parvez Kumar ◽  
Rakesh Mandal ◽  
...  

Introduction: Traumatic brain injury (TBI) in patients with head trauma is common cause for emergency visits to hospital affecting all age groups. It is one of important leading cause of death and disability worldwide besides leading to neurological disease burden. Noncontrast enhanced Multidetector computed tomography (MDCT) is imaging modality of choice for detection of various intracranial lesions. Objectives: This study was done to analyse various imaging findings on MDCT in traumatic head injury patients along with association of CT findings with clinical manifestation and mechanism of injury. Methodology: In this ethically approved prospective study, CT scan was done in 224 consecutive patients with head injury from November 2020 to February 2021. The various imaging findings seen in CT scan were documented in proforma. The data collected was analyzed with appropriate statistical test and statistical significance was calculated. Results: Total of 224 patients with diagnosis of head injury were included in the study. The male to female ratio was 2.86 and most common age group involved was between 20-40years (41.1%). The most common mode of injury was road traffic accidents (57.6%) and most of the patients presented with history of altered sensorium (35.7%). About 47.3% patients showed abnormal findings on CT scan with scalp lesion was most common findings (82%) followed by skull fractures (54.7%) and cerebral contusions (43.4%). Patients with history of RTA had more abnormal CT scan (62%) than fall injury and physical assault. Statistically significant association seen between CT scan findings with Glasgow Coma Scale and RTA (P<0.05). Conclusion: The present study showed well documented role of CT scan in diagnosis of TBI besides detection of spectrum of intracranial lesions in patients with head trauma. Road traffic accident is most common mode of head injury with most of the victims are young middle age active male. 



2014 ◽  
Vol 31 (22) ◽  
pp. 1815-1822 ◽  
Author(s):  
Linda Papa ◽  
Salvatore Silvestri ◽  
Gretchen M. Brophy ◽  
Philip Giordano ◽  
Jay L. Falk ◽  
...  


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