On the background of ever increasing HIV transmission in our community throughvarious routes, the psychosocial factors related with intravenous drug abuse has becomenecessary to be studied. Aim of the study was to assess the Socio-psychological factorsthat influence people to use drugs, especially to use Injectable drugs. We enrolled asample of 393 Intravenous drug users, all male, in the Kathmandu Valley. Participantswere administered a semi structured proforma to assess the psychosocial issues relatedwith the drug intravenous drug abuse. Mean age of the sample was 27.76+ 4.86 years.Majority were single, unemployed, Hindu and by caste Newars, with education morethan high school (SLC or more). The first psychoactive substance use by most of themwas cannabis. The most frequently used psychoactive substance was injectionBuprenorphine (Tidigesic), which was followed by mixture of various substances(opiates, benzodiazepines, antihistamines) and Diacetyl morphine (Brown sugar).Factors associated with the start of the drugs were for enjoyment, friend’s pressureand to alleviate mental tension. Many accepted Injectable drug use contributing toproblems in mental, marital, social, economic and legal aspects of their life. Despiteknowing the harms caused by the drugs majority persist on its use. A needle exchangeprogramme has been viewed positively by many.Key words: buprenorphin, needle sharing, needle replacement, HIV transmission.