Inhibitor of HSP70 expression quercetin abolishes anxiolytic effect induced by thermal preconditioning in rats

2008 ◽  
Author(s):  
M. V. Chernyshev ◽  
O. A. Sapach ◽  
Yu F. Pastukhov
Keyword(s):  
Anxiolytic Effect ◽  
Hsp70 Expression ◽  
Thermal Preconditioning

scholarly journals Molecular Imaging-Assisted Optimization of Hsp70 Expression during Laser-Induced Thermal Preconditioning for Wound Repair Enhancement

2009 ◽  
Vol 129 (1) ◽  
pp. 205-216 ◽  
Author(s):  
Gerald J. Wilmink ◽  
Susan R. Opalenik ◽  
Joshua T. Beckham ◽  
Alexander A. Abraham ◽  
Lillian B. Nanney ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Wound Repair ◽  
Hsp70 Expression ◽  
Thermal Preconditioning

Thermal Preconditioning Protocols for Cartilage Tissue Engineering

2008 ◽  
Author(s):  
Eunna Chung ◽  
M. N. Rylander
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Molecular Chaperones ◽  
Cellular Proliferation ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Hsp70 Expression ◽  
Cartilaginous Tissues ◽  
Shock Proteins ◽  
Thermal Preconditioning

Successful creation of cartilaginous engineered tissues is often limited by insufficient cellular proliferation and formation of extracellular matrix. Stress conditioning protocols using heat have been shown to induce up-regulation of molecular chaperones called heat shock proteins (HSP) [1]. These proteins have been linked to enhanced cell proliferation and collagen synthesis which is critical for formation of the extracellular matrix. Therefore, identification of effective thermal stress preconditioning protocols that enhance HSP expression could substantially advance development of replacement tissues for cartilaginous tissues [2]. Our project focused on identifying thermal preconditioning protocols that enhance HSP70 expression while minimizing cellular injury for ultimate use in improving cell proliferation and extracellular matrix formation for cartilage.

Influence of thermal preconditioning on anticonvulsive effects of valproate and memantine

2008 ◽  
Author(s):  
A. A. Yakimchuk ◽  
Yu F. Pastukhov ◽  
N. A. Frolova
Keyword(s):  
Thermal Preconditioning

Effect of thermal ablation on HSP70 expression in benign thyroid nodules

2014 ◽  
Vol 35 (11) ◽  
pp. 1215
Author(s):  
Lei YAN ◽  
Jian-quan ZHANG ◽  
Qian PAN ◽  
Jian-ming ZHENG ◽  
Yan-hong Lv
Keyword(s):  
Thermal Ablation ◽  
Thyroid Nodules ◽  
Hsp70 Expression ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

scholarly journals Critical Effects on Akt Signaling in Adult Zebrafish Brain Following Alterations in Light Exposure

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 637
Author(s):  
Nicholas S. Moore ◽  
Robert A. Mans ◽  
Mackenzee K. McCauley ◽  
Colton S. Allgood ◽  
Keri A. Barksdale
Keyword(s):  
Optic Tectum ◽  
Visual Processing ◽  
Environmental Enrichment ◽  
Glycogen Synthase ◽  
Light Exposure ◽  
Hsp70 Expression ◽  
Light Cycle ◽  
Adult Zebrafish ◽  
Sleep State ◽  
Zebrafish Brain

Evidence from human and animal studies indicate that disrupted light cycles leads to alterations of the sleep state, poor cognition, and the risk of developing neuroinflammatory and generalized health disorders. Zebrafish exhibit a diurnal circadian rhythm and are an increasingly popular model in studies of neurophysiology and neuropathophysiology. Here, we investigate the effect of alterations in light cycle on the adult zebrafish brain: we measured the effect of altered, unpredictable light exposure in adult zebrafish telencephalon, homologous to mammalian hippocampus, and the optic tectum, a significant visual processing center with extensive telencephalon connections. The expression of heat shock protein-70 (HSP70), an important cell stress mediator, was significantly decreased in optic tectum of adult zebrafish brain following four days of altered light exposure. Further, pSer473-Akt (protein kinase B) was significantly reduced in telencephalon following light cycle alteration, and pSer9-GSK3β (glycogen synthase kinase-3β) was significantly reduced in both the telencephalon and optic tectum of light-altered fish. Animals exposed to five minutes of environmental enrichment showed significant increase in pSer473Akt, which was significantly attenuated by four days of altered light exposure. These data show for the first time that unpredictable light exposure alters HSP70 expression and dysregulates Akt-GSK3β signaling in the adult zebrafish brain.

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