A Closer Look at Long-Term Effects of Childhood Trauma: A Case Example of a Child in Foster Care

2008 ◽  
Author(s):  
Veronica Chavez ◽  
Ediza Garcia ◽  
Blanca Orellana ◽  
Susan Park
Keyword(s):  
Foster Care ◽  
Childhood Trauma ◽  
Long Term Effects

Long term effects of childhood trauma on cortisol stress reactivity in adulthood and relationship to the occurrence of depression

2014 ◽  
Vol 50 ◽  
pp. 289-299 ◽  
Author(s):  
Akiko Suzuki ◽  
Lucia Poon ◽  
Andrew S. Papadopoulos ◽  
Veena Kumari ◽  
Anthony J. Cleare
Keyword(s):  
Childhood Trauma ◽  
Stress Reactivity ◽  
Long Term Effects

scholarly journals Childhood trauma and the prevalence of alcohol dependence in adulthood

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Karolina Kosecka ◽  
Ewa Stelmach
Keyword(s):  
Alcohol Dependence ◽  
Childhood Trauma ◽  
Physical Violence ◽  
Later Life ◽  
Alcohol Addiction ◽  
Long Term Effects ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Alcohol Dependence Syndrome

Abstract Introduction: The experience of trauma and stress in childhood and early adulthood can lead not only to immediate physical and psychological symptoms but also to long-term effects observed in later life. Aim and method: The objective of the following study was to search for the correlation between the occurrence of childhood trauma and its long-term outcome, that is alcohol dependence, and to review studies concerning the presence of certain personality traits in patients with such trauma experience and prognostic factors for treatment. The literature in the Google Scholar database was reviewed using the following keywords: childhood abuse, childhood trauma, alcohol addiction and alcohol use disorder. The time descriptors 2015-2021 were also used. Results: On the basis of the conducted studies, it has been found that the experience of extremely stressful situations at a young age is declared by a greater part of the examined patients with alcohol dependence syndrome. It was also noticed that the most significant and most frequently reported negative childhood experiences in patients with alcohol dependence syndrome are physical violence, parental separation or divorce, and mental illness of a family member. It was found that impulsivity, disorder, pessimism, fatigue and asthenia are some of the characteristics of this group of patients. Conclusions: It can be concluded that there is a significant correlation between the occurrence of traumatic events in childhood and the tendency to develop alcohol addiction in adulthood.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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