Purpose of the study: to study the association of alcohol dependence syndrome with the clinical and psychological characteristics of patients with organic mental disorders, aggressive behavior, and suicidal attempts. Materials and methods: we examined 842 patients with organic mental disorders, addictive disorders and aggressive behavior who made a suicide attempt from 1991 to 2018 in the Tyumen region, which were divided into two groups: 1) 421 patients who were diagnosed with an organic mental disorder (in categories F06.6, F06.7, F06. 8, F07.8): 201 men and 220 women; 2) 421 people with organic mental disorders of the above categories and alcohol dependence (F10.242, F10.252, F10.262): 208 men and 213 women. Results and discussion. According to the data of the clinical conversation, the structure of subjective indicators characterizing various disorders of the neuropsychiatric state was described in individuals with high and low levels of factors contributing to the development of suicidal behavior. When assessing the relative risk of factors contributing to the development of suicidal activity, when comparing the indicators of the clinical and mental status of men and women of the studied groups, a 95% confidence interval was determined: mood instability (1.34), psychosomatic complaints (1.03), sleep disorders (1.09), interpersonal interaction problems (1.02), psychopathic (1.48), depressive (1.11) reactions and self-esteem inadequacy (1.05). Conclusions: when comparing the indicators of the neuropsychiatric status in persons with organic mental disorders, aggressive behavior and addictive disorders who have committed suicide attempts, more than half (75.6%) of the examined persons revealed a high level of factors for the development of suicidal activity: 38.0% of women and 37.6% of men. Clinical and psychological parameters were significantly (p < 0.001) characterized by: mood instability (12.4%), difficulties in interpersonal interaction (11.6%), prenosological neurotic (8.5%), psychopathic (8.9%) and depressive (6.2%) reactions. The results obtained can be used to develop effective prevention and rehabilitation measures using digital resources.