North Dakota Early Childhood Outcomes Project

2013 ◽  
Keyword(s):  
Early Childhood ◽  
North Dakota ◽  
Early Childhood Outcomes

scholarly journals Elevated serum IL-10 is associated with severity of neonatal encephalopathy and adverse early childhood outcomes

2021 ◽  
Author(s):  
Raymand Pang ◽  
Brian M. Mujuni ◽  
Kathryn A. Martinello ◽  
Emily L. Webb ◽  
Angela Nalwoga ◽  
...  
Keyword(s):  
Early Childhood ◽  
Neonatal Mortality ◽  
Child Death ◽  
Elevated Serum ◽  
Adverse Outcomes ◽  
List Type ◽  
Perinatal Infection ◽  
Neonatal Encephalopathy ◽  
Early Childhood Outcomes ◽  
Sub Saharan

Abstract Background Neonatal encephalopathy (NE) contributes substantially to child mortality and disability globally. We compared cytokine profiles in term Ugandan neonates with and without NE, with and without perinatal infection or inflammation and identified biomarkers predicting neonatal and early childhood outcomes. Methods In this exploratory biomarker study, serum IL-1α, IL-6, IL-8, IL-10, TNFα, and VEGF (<12 h) were compared between NE and non-NE infants with and without perinatal infection/inflammation. Neonatal (severity of NE, mortality) and early childhood (death or neurodevelopmental impairment to 2.5 years) outcomes were assessed. Predictors of outcomes were explored with multivariable linear and logistic regression and receiver-operating characteristic analyses. Results Cytokine assays on 159 NE and 157 non-NE infants were performed; data on early childhood outcomes were available for 150 and 129, respectively. NE infants had higher IL-10 (p < 0.001), higher IL-6 (p < 0.017), and lower VEGF (p < 0.001) levels. Moderate and severe NE was associated with higher IL-10 levels compared to non-NE infants (p < 0.001). Elevated IL-1α was associated with perinatal infection/inflammation (p = 0.013). Among NE infants, IL-10 predicted neonatal mortality (p = 0.01) and adverse early childhood outcome (adjusted OR 2.28, 95% CI 1.35–3.86, p = 0.002). Conclusions Our findings support a potential role for IL-10 as a biomarker for adverse outcomes after neonatal encephalopathy. Impact Neonatal encephalopathy is a common cause of child death and disability globally. Inflammatory cytokines are potential biomarkers of encephalopathy severity and outcome. In this Ugandan health facility-based cohort, neonatal encephalopathy was associated with elevated serum IL-10 and IL-6, and reduced VEGF at birth. Elevated serum IL-10 within 12 h after birth predicted severity of neonatal encephalopathy, neonatal mortality, and adverse early childhood developmental outcomes, independent of perinatal infection or inflammation, and provides evidence to the contribution of the inflammatory processes. Our findings support a role for IL-10 as a biomarker for adverse outcomes after neonatal encephalopathy in a sub-Saharan African cohort.

scholarly journals Optimal timing of antenatal corticosteroid administration and preterm neonatal and early childhood outcomes

2020 ◽  
Vol 2 (1) ◽  
pp. 100077 ◽  
Author(s):  
Ashley N. Battarbee ◽  
Stephanie T. Ros ◽  
M. Sean Esplin ◽  
Joseph Biggio ◽  
Radek Bukowski ◽  
...  
Keyword(s):  
Early Childhood ◽  
Optimal Timing ◽  
Antenatal Corticosteroid ◽  
Corticosteroid Administration ◽  
Early Childhood Outcomes

Congenital defects and early childhood outcomes following in-utero exposure to antihypertensive medication

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Catherine A. Fitton ◽  
Michael Fleming ◽  
Lorna Aucott ◽  
Jill P. Pell ◽  
Daniel F. Mackay ◽  
...  
Keyword(s):  
Early Childhood ◽  
Antihypertensive Medication ◽  
In Utero ◽  
Congenital Defects ◽  
In Utero Exposure ◽  
Early Childhood Outcomes

scholarly journals No Strings Attached: The Impact of an Unconditional Prenatal Income Supplement on First Nations Birth and Early Childhood Outcomes

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Marni Brownell ◽  
Mariette Chartier ◽  
Nathan Nickel ◽  
Rhonda Campbell ◽  
Jennifer Enns ◽  
...  
Keyword(s):  
Early Childhood ◽  
Birth Weight ◽  
Low Birth Weight ◽  
First Nations ◽  
Birth Outcomes ◽  
Gestational Age ◽  
Low Income ◽  
Large For Gestational Age ◽  
Breastfeeding Initiation ◽  
Early Childhood Outcomes

IntroductionIn Manitoba, low-income pregnant women are eligible for the Healthy Baby Prenatal Benefit (HBPB), an unconditional income supplement provided during the second and third trimester of pregnancy. HBPB is associated with improved birth outcomes for Manitoba women; its association with birth outcomes for First Nations (Indigenous) women is unknown. Objectives and ApproachTo determine the association between HBPB and First Nations’ (FN) newborn and early childhood outcomes, we linked whole-population data from health, public health, family services and education. We included only FN women receiving income assistance during pregnancy (n=7074) to develop comparable treatment (received HBPB; n=5283) and comparison (no HBPB; n=1791) groups. Propensity score weighting adjusted for differences in maternal characteristics between groups. Multi-variable regressions compared groups on breastfeeding initiation, low birth weight, preterm birth, small- and large-for-gestational age, Apgar scores, complete immunizations at 1 and 2 years, and developmental vulnerability in kindergarten measured with the Early Development Instrument (EDI). ResultsReceipt of the HBPB was associated with reductions in low birth weight births (adjusted Relative Risk (aRR): 0.77; 95% CI: 0.63, 0.93) and preterm births (aRR: 0.78 (0.68, 0.90)), and increases in breastfeeding initiation (aRR: 1.05 (1.00, 1.09)) and large-for-gestational age births (aRR: 1.11 (1.01, 1.23)). HBPB receipt during pregnancy was also associated with increases in 1- and 2-year immunizations for FN children (aRR: 1.14 (1.09, 1.19), and aRR: 1.28 (1.19, 1.36), respectively). Reductions in the risk of being developmentally vulnerable in the language and cognitive domain of the EDI were also found for FN children whose mothers had received the HBPB during pregnancy (aRR: 0.85 (0.74, 0.97). Conclusion/ImplicationsA modest unconditional income supplement during pregnancy was associated with improved birth outcomes, increased immunization rates, and improved language and cognitive development at kindergarten for children born to low-income First Nations women. Long-term strategies to address structural inequities and the ongoing effects of colonization are also needed.

Poor early childhood outcomes attributable to maternal depression in Mexican women

2017 ◽  
Vol 20 (4) ◽  
pp. 561-568 ◽  
Author(s):  
Filipa de Castro ◽  
Jean Marie Place ◽  
Aremis Villalobos ◽  
Rosalba Rojas ◽  
Tonatiuh Barrientos ◽  
...  
Keyword(s):  
Early Childhood ◽  
Maternal Depression ◽  
Mexican Women ◽  
Early Childhood Outcomes
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