Event-related potential (ERP) measures of auditory sensory gating: Pitch and interval parameters

Abstract. Sensory gating allows an individual to filter out irrelevant sensory information from the environment, potentially freeing attentional resources for more complex tasks. Some work has demonstrated a relationship between auditory sensory gating and cognitive skills such as executive function, although the functional significance is not well understood. The relationship between sensory gating and personality dimensions has not been adequately explored. Participants completed a paired-tone sensory gating event-related potential (ERP) paradigm and the Big Five Inventory to assess personality characteristics. Participants with more robust P50 sensory gating reported a significantly greater degree of conscientiousness; conscientiousness (but not the other Big Five factors) predicted sensory gating ability. Longer ERP latencies were associated with participants being more conscientious (P50 component), more agreeable, and less neurotic (N100 component). A better understanding of the behavioral correlates of sensory gating will help elucidate the functional consequences of reduced sensory gating both in typical adults and clinical groups.

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Cortical correlates of auditory sensory gating: A simultaneous near-infrared spectroscopy event-related potential study

Neuroscience ◽

10.1016/j.neuroscience.2009.01.015 ◽

2009 ◽

Vol 159 (3) ◽

pp. 1032-1043 ◽

Cited By ~ 39

Author(s):

A.-C. Ehlis ◽

T.M. Ringel ◽

M.M. Plichta ◽

M.M. Richter ◽

M.J. Herrmann ◽

...

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Sensory Gating ◽

Event Related Potential ◽

Potential Study ◽

Auditory Sensory Gating

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P50, N100, and P200 Sensory Gating in Panic Disorder

Clinical EEG and Neuroscience ◽

10.1177/1550059419899324 ◽

2020 ◽

Vol 51 (5) ◽

pp. 317-324 ◽

Cited By ~ 2

Author(s):

Lars Thoma ◽

Johannes Rentzsch ◽

Katharina Gaudlitz ◽

Nicole Tänzer ◽

Jürgen Gallinat ◽

...

Keyword(s):

Information Processing ◽

Panic Disorder ◽

Cognitive Processing ◽

Sensory Gating ◽

Event Related Potential ◽

Clinical Population ◽

Healthy Controls ◽

Auditory Sensory Gating ◽

Processing Deficits ◽

Information Processing Deficits

Panic disorder (PD) has been linked to abnormalities in information processing. However, only little evidence has been published for sensory gating in PD. Sensory gating describes the brain’s ability to exclude stimuli of low relevance from higher level information processing, thereby sustaining efficient cognitive processing. Deficits in sensory gating have been associated with various psychiatric conditions, most prominently schizophrenia. In this case-control event-related potential study, we tested 32 patients with PD and 39 healthy controls in a double click paradigm. Both groups were compared with regard to pre-attentive (P50), early-attentive (N100), and late-attentive (P200) sensory gating indices. Contrary to a hypothesized deficit, PD patients and healthy controls showed no differences in P50, N100 and P200 values. These results suggest that sensory gating seems to be functional across the pre-attentive, early-attentive, and late-attentive time span in this clinical population. Given this consistency across auditory sensory gating indices, further research aiming to clarify information processing deficits in PD should focus on other neurophysiological markers to investigate information processing deficits in PD (eg, P300, error-related negativity or mismatch negativity).

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The Influence of Background Auditory Noise on P50 and N100 Suppression Elicited by the Paired-Click Paradigm

Journal of Psychophysiology ◽

10.1027/0269-8803/a000245 ◽

2020 ◽

Vol 34 (3) ◽

pp. 171-178

Author(s):

Samantha Major ◽

Kimberly Carpenter ◽

Logan Beyer ◽

Hannah Kwak ◽

Geraldine Dawson ◽

...

Keyword(s):

Sensory Gating ◽

Autism Spectrum ◽

Inhibitory Response ◽

Future Research ◽

Typically Developing ◽

Optimal Outcomes ◽

Hyperactivity Disorder ◽

Auditory Sensory Gating ◽

Auditory Noise ◽

P50 Suppression

Abstract. Auditory sensory gating is commonly assessed using the Paired-Click Paradigm (PCP), an electroencephalography (EEG) task in which two identical sounds are presented sequentially and the brain’s inhibitory response to the second sound is measured. Many clinical populations demonstrate reduced P50 and/or N100 suppression. Testing sensory gating in children may help to identify individuals at risk for neurodevelopmental disorders earlier, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which could lead to more optimal outcomes. Minimal research has been done with children because of the difficulty of performing lengthy EEG experiments with young children, requiring them to sit still for long periods of time. We designed a modified, potentially child-friendly version of the PCP and evaluated it in typically developing adults. The PCP was administered twice, once in a traditional silent room (silent movie condition) and once with an audible movie playing (audible movie condition) to minimize boredom and enhance behavioral compliance. We tested whether P50 and N100 suppression were influenced by the presence of the auditory background noise from the movie. N100 suppression was observed in both hemispheres in the silent movie condition and in the left hemisphere only during the audible movie condition, though suppression was attenuated in the audible movie condition. P50 suppression was not observed in either condition. N100 sensory gating was successfully elicited with an audible movie playing during the PCP, supporting the use of the modified task for future research in both children and adults.

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The interaction between auditory sensory gating and hippocampal long term potentiation

Schizophrenia Research ◽

10.1016/0920-9964(93)90307-5 ◽

1993 ◽

Vol 9 (2-3) ◽

pp. 164

Author(s):

ChristineL. Miller ◽

PaulaC. Bickford

Keyword(s):

Sensory Gating ◽

Long Term Potentiation ◽

Term Potentiation ◽

Auditory Sensory Gating

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Sleep Extension Normalizes ERP of Waking Auditory Sensory Gating in Healthy Habitually Short Sleeping Individuals

PLoS ONE ◽

10.1371/journal.pone.0059007 ◽

2013 ◽

Vol 8 (3) ◽

pp. e59007 ◽

Cited By ~ 12

Author(s):

Valentina Gumenyuk ◽

Oleg Korzyukov ◽

Thomas Roth ◽

Susan M. Bowyer ◽

Christopher L. Drake

Keyword(s):

Sensory Gating ◽

Auditory Sensory Gating ◽

Sleep Extension

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Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders

Brain Sciences ◽

10.3390/brainsci11121581 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1581

Author(s):

Alexis E. Whitton ◽

Kathryn E. Lewandowski ◽

Mei-Hua Hall

Keyword(s):

Bipolar Disorder ◽

Prediction Error ◽

Psychotic Disorders ◽

Predictive Coding ◽

Sensory Gating ◽

Event Related Potential ◽

Reward Learning ◽

Smoking History ◽

Impaired Performance ◽

Psychotic Bipolar Disorder

Motivational and perceptual disturbances co-occur in psychosis and have been linked to aberrations in reward learning and sensory gating, respectively. Although traditionally studied independently, when viewed through a predictive coding framework, these processes can both be linked to dysfunction in striatal dopaminergic prediction error signaling. This study examined whether reward learning and sensory gating are correlated in individuals with psychotic disorders, and whether nicotine—a psychostimulant that amplifies phasic striatal dopamine firing—is a common modulator of these two processes. We recruited 183 patients with psychotic disorders (79 schizophrenia, 104 psychotic bipolar disorder) and 129 controls and assessed reward learning (behavioral probabilistic reward task), sensory gating (P50 event-related potential), and smoking history. Reward learning and sensory gating were correlated across the sample. Smoking influenced reward learning and sensory gating in both patient groups; however, the effects were in opposite directions. Specifically, smoking was associated with improved performance in individuals with schizophrenia but impaired performance in individuals with psychotic bipolar disorder. These findings suggest that reward learning and sensory gating are linked and modulated by smoking. However, disorder-specific associations with smoking suggest that nicotine may expose pathophysiological differences in the architecture and function of prediction error circuitry in these overlapping yet distinct psychotic disorders.

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