Brown Norway rats, a putative schizophrenia model, show increased electroencephalographic activity at rest and decreased event-related potential amplitude, power, and coherence in the auditory sensory gating paradigm

2015 ◽  
Vol 166 (1-3) ◽  
pp. 171-177 ◽  
Author(s):  
Yoshiro Tomimatsu ◽  
Ryosuke Hibino ◽  
Hiroyuki Ohta
Keyword(s):  
Sensory Gating ◽  
Event Related Potential ◽  
Brown Norway ◽  
Potential Amplitude ◽  
Auditory Sensory Gating ◽  
Electroencephalographic Activity ◽  
Gating Paradigm ◽  
Norway Rats

scholarly journals Relevance of Attention in Auditory Sensory Gating Paradigms in Schizophrenia

2011 ◽  
Vol 25 (2) ◽  
pp. 60-66 ◽  
Author(s):  
Klevest Gjini ◽  
Scott Burroughs ◽  
Nash N. Boutros
Keyword(s):  
Visual Attention ◽  
Sensory Gating ◽  
Control Measures ◽  
Group Differences ◽  
Continuous Performance ◽  
Continuous Performance Task ◽  
Visual Distraction ◽  
Auditory Sensory Gating ◽  
Neurological Conditions ◽  
Gating Paradigm

The paired-click paradigm (PCP) is widely used to study sensory habituation or gating in a number of psychiatric and neurological conditions. The classic paradigm does not control for attentional factors. In order to assess the influences of incorporating attentional control measures we administered the auditory PCP (S1-S2) in three different attention (passive, auditory attention to S2, visual attention to a concurrent continuous performance task, CPT) conditions to a group of chronic, medicated schizophrenia patients (N = 12) and a group of healthy subjects (N = 15) to evaluate the effects of attention on sensory gating measures. A significant effect of attention on S1 amplitudes was shown for P50 in both groups, and N100 or P200 in schizophrenia patients. Attention status had a significant effect on S2 amplitudes for N100 and P200, and N100 and P200 gating ratios. Despite the effect of attention on S1 P50 amplitudes there was no effect on the gating ratio. In terms of group differences, visual attention to the concurrent CPT during the paired-click sensory gating task significantly enhanced the detection of deficient gating of the N100 and P200 components in schizophrenia patients. The data support the continued utilization of the passive gating paradigm for examining P50 gating but strongly suggest that for studies examining gating of the N100 or P200 components, a visual distraction paradigm may enhance the detection of abnormal gating in schizophrenia patients.

Auditory Sensory Gating and the Big Five Personality Factors

2019 ◽  
Vol 33 (4) ◽  
pp. 276-285
Author(s):  
Carly A. Yadon ◽  
Timothy K. Daugherty
Keyword(s):  
Big Five ◽  
Cognitive Skills ◽  
Sensory Information ◽  
Sensory Gating ◽  
Event Related Potential ◽  
Personality Factors ◽  
Big Five Personality ◽  
Behavioral Correlates ◽  
Five Factors ◽  
Auditory Sensory Gating

Abstract. Sensory gating allows an individual to filter out irrelevant sensory information from the environment, potentially freeing attentional resources for more complex tasks. Some work has demonstrated a relationship between auditory sensory gating and cognitive skills such as executive function, although the functional significance is not well understood. The relationship between sensory gating and personality dimensions has not been adequately explored. Participants completed a paired-tone sensory gating event-related potential (ERP) paradigm and the Big Five Inventory to assess personality characteristics. Participants with more robust P50 sensory gating reported a significantly greater degree of conscientiousness; conscientiousness (but not the other Big Five factors) predicted sensory gating ability. Longer ERP latencies were associated with participants being more conscientious (P50 component), more agreeable, and less neurotic (N100 component). A better understanding of the behavioral correlates of sensory gating will help elucidate the functional consequences of reduced sensory gating both in typical adults and clinical groups.

Cortical correlates of auditory sensory gating: A simultaneous near-infrared spectroscopy event-related potential study

Neuroscience ◽  
2009 ◽  
Vol 159 (3) ◽  
pp. 1032-1043 ◽  
Author(s):  
A.-C. Ehlis ◽  
T.M. Ringel ◽  
M.M. Plichta ◽  
M.M. Richter ◽  
M.J. Herrmann ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Sensory Gating ◽  
Event Related Potential ◽  
Potential Study ◽  
Auditory Sensory Gating

P50, N100, and P200 Sensory Gating in Panic Disorder

2020 ◽  
Vol 51 (5) ◽  
pp. 317-324 ◽  
Author(s):  
Lars Thoma ◽  
Johannes Rentzsch ◽  
Katharina Gaudlitz ◽  
Nicole Tänzer ◽  
Jürgen Gallinat ◽  
...  
Keyword(s):  
Information Processing ◽  
Panic Disorder ◽  
Cognitive Processing ◽  
Sensory Gating ◽  
Event Related Potential ◽  
Clinical Population ◽  
Healthy Controls ◽  
Auditory Sensory Gating ◽  
Processing Deficits ◽  
Information Processing Deficits

Panic disorder (PD) has been linked to abnormalities in information processing. However, only little evidence has been published for sensory gating in PD. Sensory gating describes the brain’s ability to exclude stimuli of low relevance from higher level information processing, thereby sustaining efficient cognitive processing. Deficits in sensory gating have been associated with various psychiatric conditions, most prominently schizophrenia. In this case-control event-related potential study, we tested 32 patients with PD and 39 healthy controls in a double click paradigm. Both groups were compared with regard to pre-attentive (P50), early-attentive (N100), and late-attentive (P200) sensory gating indices. Contrary to a hypothesized deficit, PD patients and healthy controls showed no differences in P50, N100 and P200 values. These results suggest that sensory gating seems to be functional across the pre-attentive, early-attentive, and late-attentive time span in this clinical population. Given this consistency across auditory sensory gating indices, further research aiming to clarify information processing deficits in PD should focus on other neurophysiological markers to investigate information processing deficits in PD (eg, P300, error-related negativity or mismatch negativity).

The Influence of Background Auditory Noise on P50 and N100 Suppression Elicited by the Paired-Click Paradigm

2020 ◽  
Vol 34 (3) ◽  
pp. 171-178
Author(s):  
Samantha Major ◽  
Kimberly Carpenter ◽  
Logan Beyer ◽  
Hannah Kwak ◽  
Geraldine Dawson ◽  
...  
Keyword(s):  
Sensory Gating ◽  
Autism Spectrum ◽  
Inhibitory Response ◽  
Future Research ◽  
Typically Developing ◽  
Optimal Outcomes ◽  
Hyperactivity Disorder ◽  
Auditory Sensory Gating ◽  
Auditory Noise ◽  
P50 Suppression

Abstract. Auditory sensory gating is commonly assessed using the Paired-Click Paradigm (PCP), an electroencephalography (EEG) task in which two identical sounds are presented sequentially and the brain’s inhibitory response to the second sound is measured. Many clinical populations demonstrate reduced P50 and/or N100 suppression. Testing sensory gating in children may help to identify individuals at risk for neurodevelopmental disorders earlier, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which could lead to more optimal outcomes. Minimal research has been done with children because of the difficulty of performing lengthy EEG experiments with young children, requiring them to sit still for long periods of time. We designed a modified, potentially child-friendly version of the PCP and evaluated it in typically developing adults. The PCP was administered twice, once in a traditional silent room (silent movie condition) and once with an audible movie playing (audible movie condition) to minimize boredom and enhance behavioral compliance. We tested whether P50 and N100 suppression were influenced by the presence of the auditory background noise from the movie. N100 suppression was observed in both hemispheres in the silent movie condition and in the left hemisphere only during the audible movie condition, though suppression was attenuated in the audible movie condition. P50 suppression was not observed in either condition. N100 sensory gating was successfully elicited with an audible movie playing during the PCP, supporting the use of the modified task for future research in both children and adults.

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