The effects of environmental enrichment on nicotine condition place preference in male rats.

Abstract Rationale Mephedrone is a frequently overused drug of abuse that belongs to the group of novel psychoactive substances. Although its mechanism of action, as well as toxic and psychoactive effects, has been widely studied, the role of different factors that could contribute to the increased vulnerability to mephedrone abuse is still poorly understood. Objectives The aim of the presented study was to assess the impact of several factors (sex differences, social-conditioning, and chronic mild unpredictable stress — CMUS) on the liability to mephedrone-induced reward in Wistar rats. Methods The rewarding effects of mephedrone in male and female rats were assessed using the conditioned place preference (CPP) procedure. Furthermore, the impact of social factor and stress was evaluated in male rats using social-CPP and CMUS-dependent CPP, respectively. Results Mephedrone induced classic-CPP in female (10 mg/kg), as well as in male (10 and 20 mg/kg) rats. However, the impact of mephedrone treatment during social-CPP was highly dose-dependent as the rewarding effects of low dose of mephedrone (5 mg/kg; non-active in classic-CPP) were potentiated when administered during social-conditioning. Interestingly, social-conditioning with a higher dose of 20 mg/kg (that induced classic-CPP) was able to reverse these effects. Finally, CMUS potentiated rewarding effects of a low dose of mephedrone (5 mg/kg) and increased the level of corticosterone in rats’ prefrontal cortex and hippocampus. Conclusions Altogether, the presented results give new insight into possible factors underlying the vulnerability to mephedrone abuse and can serve as a basis for further studies assessing mechanisms underlying observed effects.

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The influence of electrical stimulation on dorsal raphe nucleus with different current intensities on morphine-induced conditioned place preference in male rats

Pharmacological Reports ◽

10.1016/j.pharep.2015.01.006 ◽

2015 ◽

Vol 67 (5) ◽

pp. 832-836 ◽

Cited By ~ 2

Author(s):

Gholam Reza Ghavipanjeh ◽

Ali Asghar Pourshanazari ◽

Hojjatllah Alaei ◽

Sara Karimi

Keyword(s):

Electrical Stimulation ◽

Conditioned Place Preference ◽

Dorsal Raphe Nucleus ◽

Dorsal Raphe ◽

Place Preference ◽

Raphe Nucleus ◽

Male Rats ◽

Dorsal Raphé

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MDMA produces a conditioned place preference and elicits ejaculation in male rats: A modulatory role for the endogenous opioids

Pharmacology Biochemistry and Behavior ◽

10.1016/0091-3057(91)90577-o ◽

1991 ◽

Vol 40 (2) ◽

pp. 443-447 ◽

Cited By ~ 44

Author(s):

Edward J. Bilsky ◽

Christopher L. Hubbell ◽

John D. Delconte ◽

Larry D. Reid

Keyword(s):

Conditioned Place Preference ◽

Place Preference ◽

Endogenous Opioids ◽

Male Rats

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The Effect of the mGlu8 Receptor Agonist, S-3,4-DCPG on Acquisition and Expression of Morphine-induced Conditioned Place Preference in Male rats

10.21203/rs.3.rs-114995/v2 ◽

2021 ◽

Author(s):

Nazanin Kahvandi ◽

Zahra Ebrahimi ◽

Seyed Asaad Karimi ◽

Siamak Shahidi ◽

Iraj Salehi ◽

...

Keyword(s):

Conditioned Place Preference ◽

Metabotropic Glutamate Receptors ◽

Preference Test ◽

Place Preference ◽

Male Rats ◽

Dependent Manner ◽

Metabotropic Glutamate ◽

Male Wistar Rats ◽

Dose Dependent

Abstract Background: The nucleus accumbens (NAc) plays a principal role in drug reward. It has been reported that metabotropic glutamate receptors (mGlu receptors) play a key role in the rewarding pathway(s). Previous studies have shown the vast allocation of the different types of mGlu receptors, including mGlu8 receptors, in regions that are associated with opioid rewards, such as the NAc. The aim of the present study was to evaluate the role of mGlu8 receptors within the NAc in the acquisition and expression phases of morphine induced conditioned place preference (CPP). Adult male Wistar rats were bilaterally implanted by two cannulas' in the NAc and were evaluated in a CPP paradigm. Selective mGlu8 receptor allosteric agonist (S-3,4-DCPG) was administered at doses of 0.03, 0.3, and 3 μg/0.5 μL saline per side into the NAc on both sides during the 3 days of morphine (5 mg/kg) conditioning (acquisition) phase, or before place preference test, or post-conditioning (expression) phase of morphine-induced CPP. Results: The results revealed that intra-accumbal administration of S-3,4-DCPG (0.3 and 3 μg) markedly decreased the acquisition in a dose-dependent manner but had no effect on expression of morphine-induced CPP. Conclusions: The findings suggest that activation of mGlu8 receptors in the NAc dose-dependently blocks the establishment of morphine-induced CPP and reduces the rewarding properties of morphine which may be related to the glutamate activity into the NAc and in reward pathway(s). These data suggest that mGlu8 receptor may be involved in conditioned morphine reward.

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