scholarly journals 1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase

2017 ◽  
Vol 38 (4) ◽  
pp. 561-570 ◽  
Author(s):  
Chun Peng ◽  
Xin-ming Qi ◽  
Ling-ling Miao ◽  
Jin Ren
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
M Phase

Effect and mechanism of YB-1 knockdown on glioma cell growth, migration, and apoptosis

2020 ◽  
Vol 52 (2) ◽  
pp. 168-179 ◽  
Author(s):  
Huilin Gong ◽  
Shan Gao ◽  
Chenghuan Yu ◽  
Meihe Li ◽  
Ping Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Growth ◽  
Glioma Cell ◽  
Cell Transformation ◽  
Malignant Cell ◽  
Protein Levels ◽  
Glioma Progression

Abstract Y-box binding protein 1 (YB-1) is manifested as its involvement in cell proliferation and differentiation and malignant cell transformation. Overexpression of YB-1 is associated with glioma progression and patient survival. The aim of this study is to investigate the influence of YB-1 knockdown on glioma cell progression and reveal the mechanisms of YB-1 knockdown on glioma cell growth, migration, and apoptosis. It was found that the knockdown of YB-1 decreased the mRNA and protein levels of YB-1 in U251 glioma cells. The knockdown of YB-1 significantly inhibited cell proliferation, colony formation, and migration in vitro and tumor growth in vivo. Proteome and phosphoproteome data revealed that YB-1 is involved in glioma progression through regulating the expression and phosphorylation of major proteins involved in cell cycle, adhesion, and apoptosis. The main regulated proteins included CCNB1, CCNDBP1, CDK2, CDK3, ADGRG1, CDH-2, MMP14, AIFM1, HO-1, and BAX. Furthermore, it was also found that YB-1 knockdown is associated with the hypo-phosphorylation of ErbB, mTOR, HIF-1, cGMP-PKG, and insulin signaling pathways, and proteoglycans in cancer. Our findings indicated that YB-1 plays a key role in glioma progression in multiple ways, including regulating the expression and phosphorylation of major proteins associated with cell cycle, adhesion, and apoptosis.

Silencing of Hypoxia Inducible Factor-1α by RNA Interference Attenuates Human Glioma Cell Growth In vivo

2007 ◽  
Vol 13 (8) ◽  
pp. 2441-2448 ◽  
Author(s):  
David L. Gillespie ◽  
Kum Whang ◽  
Brian T. Ragel ◽  
Jeannette R. Flynn ◽  
David A. Kelly ◽  
...  
Keyword(s):  
Rna Interference ◽  
Cell Growth ◽  
Glioma Cell ◽  
Hypoxia Inducible Factor ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in Vitro and Rapidly Growing Tumors in Vivo

2008 ◽  
Vol 327 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Austin M. Guo ◽  
Ju Sheng ◽  
Gloria M. Scicli ◽  
Ali S. Arbab ◽  
Norman L. Lehman ◽  
...  
Keyword(s):  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell

Co-delivery of as-miR-21 and 5-FU by Poly(amidoamine) Dendrimer Attenuates Human Glioma Cell Growth in Vitro

2010 ◽  
Vol 21 (3) ◽  
pp. 303-314 ◽  
Author(s):  
Yu Ren ◽  
Chun-Sheng Kang ◽  
Xu-Bo Yuan ◽  
Xuan Zhou ◽  
Peng Xu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell

scholarly journals APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo

2010 ◽  
Vol 13 (2) ◽  
pp. 155-164 ◽  
Author(s):  
G. Eisele ◽  
P. Roth ◽  
K. Hasenbach ◽  
S. Aulwurm ◽  
F. Wolpert ◽  
...  
Keyword(s):  
Cell Death ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Cd95 Ligand

scholarly journals Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo

2014 ◽  
Vol 10 (6) ◽  
pp. 2843-2850 ◽  
Author(s):  
XUEZHEN LI ◽  
XIN HE ◽  
WEI TIAN ◽  
JIANZHEN WANG
Keyword(s):  
Cell Cycle ◽  
Glioma Cell ◽  
Human Glioma ◽  
Hairpin Rna ◽  
Cycle Arrest ◽  
Rna Targeting ◽  
Glioma Cell Proliferation ◽  
Short Hairpin

scholarly journals MicroRNA-585 inhibits human glioma cell proliferation by directly targeting MDM2

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wangsheng Chen ◽  
Lan Hong ◽  
Changlong Hou ◽  
Yibin Wang ◽  
Fei Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Human Glioma Cell ◽  
Glioma Cell Proliferation

Abstract Background MicroRNAs (miRNAs) are important regulators for cancer cell proliferation. miR-585 has been shown to inhibit the proliferation of several types of cancer, however, little is known about its role in human glioma cells. Methods miR-585 levels in human glioma clinical samples and cell lines were examined by quantitative real-time PCR (qRT-PCR) analysis. Cell proliferation was measured by Cell Counting Kit-8 (CCK-8) and EdU incorporation assays in vitro. For in vivo investigations, U251 cells were intracranially inoculated in BALB/c nude mice and xenografted tumors were visualized by magnetic resonance imaging (MRI). Results miR-585 expression is downregulated in human glioma tissues and cell lines compared with non-cancerous counterparts. Additionally, miR-585 overexpression inhibits and its knockdown promotes human glioma cell proliferation in vitro. Moreover, miR-585 overexpression also inhibits the growth of glioma xenografts in vivo, suggesting that miR-585 may act as a tumor suppressor to inhibit the proliferation of human glioma. Furthermore, miR-585 directly targets and decreases the expression of oncoprotein murine double minute 2 (MDM2). More importantly, the restoration of MDM2 via enforced overexpression markedly rescues miR-585 inhibitory effect on human glioma cell proliferation, thus demonstrating that targeting MDM2 is a critical mechanism by which miR-585 inhibits human glioma cell proliferation. Conclusions Our study unveils the anti-proliferative role of miR-585 in human glioma cells, and also implicates its potential application in clinical therapy.

scholarly journals Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro

2015 ◽  
Vol 36 (4) ◽  
pp. 1012-1018 ◽  
Author(s):  
BING ZHAO ◽  
GANG ZONG ◽  
YONGSHENG XIE ◽  
JIA LI ◽  
HONGLIANG WANG ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioma Cell ◽  
Short Hairpin Rna ◽  
Human Glioma ◽  
Hairpin Rna ◽  
Human Glioma Cell ◽  
Short Hairpin

scholarly journals The failure of human leukocyte interferon to influence the growth of human glioma cell populations: in vitro and in vivo studies

1983 ◽  
Vol 48 (6) ◽  
pp. 819-825 ◽  
Author(s):  
N J Bradley ◽  
J L Darling ◽  
N Oktar ◽  
H J Bloom ◽  
D G Thomas ◽  
...  
Keyword(s):  
Glioma Cell ◽  
Human Leukocyte ◽  
In Vivo Studies ◽  
Cell Populations ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Human Leukocyte Interferon
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