Comparative efficacy of stabilized stannous fluoride/sodium hexametaphosphate dentifrice and sodium fluoride/triclosan/copolymer dentifrice for the prevention of periodontitis in xerostomic patients: a 2-year randomized clinical trial

BDJ ◽  
2008 ◽  
Vol 204 (3) ◽  
pp. 139-139
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Sodium Fluoride ◽  
Sodium Hexametaphosphate ◽  
Comparative Efficacy ◽  
Stannous Fluoride

scholarly journals A Randomized Clinical Trial to Compare Plaque Inhibition of a Sodium Fluoride/Potassium Nitrate Dentifrice versus a Stabilized Stannous Fluoride/ Sodium Hexametaphosphate Dentifrice

2009 ◽  
Vol 10 (2) ◽  
pp. 1-9 ◽  
Author(s):  
Matthew L. Barker ◽  
Philip G. Bellamy ◽  
Nichelle Khera ◽  
Trevor N. Day ◽  
Andrew J. Mussett
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Sodium Fluoride ◽  
Potassium Nitrate ◽  
Dental Erosion ◽  
Positive Control ◽  
Sodium Hexametaphosphate ◽  
Double Blind ◽  
Plaque Area ◽  
Stannous Fluoride

Abstract Aim To compare the plaque inhibition efficacy of a sodium fluoride/potassium nitrate (NaF/KNO3 with 1450 ppm F) test dentifrice to a 0.454% stannous fluoride/sodium hexametaphosphate/sodium fluoride positive control dentifrice (SnF2/SHMP with 1450 ppm F). Methods and Materials Twenty-five subjects were randomized to a two-period, two-treatment, double blind crossover sequence using NaF/KNO3 (Sensodyne® ProNamel™ dentifrice) and SnF2/SHMP (blend-a-med®* EXPERT GUMS PROTECTION dentifrice). Each treatment was conducted with a standard manual toothbrush (Oral-B® P35 Indicator). Digital plaque image analysis (DPIA) was used on three consecutive days to evaluate: (a) overnight plaque formation (A.M. pre-brushing); (b) following 40 seconds of brushing with the test product (A.M. post-brushing); and (c) mid-afternoon (P.M.). Images were analysed using an objective computer algorithm to calculate the total area of visible plaque. A four-day washout period was instituted for the crossover phase. Results All 25 subjects completed the study. The SnF2/SHMP positive control dentifrice provided statistically significantly lower levels of plaque area coverage versus the NaF/KNO3 test dentifrice at each timepoint. For the SnF2/SHMP dentifrice, plaque coverage was 23.0% lower (p<0.0001) at A.M. pre-brushing, 17.3% (p=0.0163) lower at A.M. post-brushing, and 22.6% (p= 0.0004) lower at the P.M. measure relative to the NaF/KNO3 dentifrice. Conclusion The SnF2/SHMP dentifrice (blend-a-med® EXPERT GUMS PROTECTION) inhibits plaque regrowth both overnight and during the day to a significantly greater degree than the NaF/KNO3 dentifrice (Sensodyne® ProNamel™). Clinical Significance Dentists recommending an effective home use dentifrice for patients experiencing dentinal hypersensitivity and/or dental erosion may previously have needed to compromise on other key benefits, such as plaque control. blend-a-med® EXPERT GUMS PROTECTION is a dentifrice when integrated into an oral hygiene routine can provide a proven treatment for hypersensitivity, dental erosion, and a reduction in the regrowth of plaque. Citation Bellamy PG, Khera N, Day TN, Barker ML, Mussett AJ. A Randomized Clinical Trial to Compare Plaque Inhibition of a Sodium Fluoride/Potassium Nitrate Dentifrice versus a Stabilized Stannous Fluoride/ Sodium Hexametaphosphate Dentifrice. J Contemp Dent Pract 2009 March; (10)2:001-009. * Also branded Crest® and Ipana, depending on the country.

scholarly journals Comparative efficacy of two daily use mouthrinses: randomized clinical trial using an experimental gingivitis model

2011 ◽  
Vol 25 (4) ◽  
pp. 338-344 ◽  
Author(s):  
Christine Ann Charles ◽  
James Anthony McGuire ◽  
Naresh Chandra Sharma ◽  
James Qaqish
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Comparative Efficacy ◽  
Experimental Gingivitis

Anti-gingivitis efficacy of a stabilized 0.454% stannous fluoride/sodium hexametaphosphate dentifrice. A controlled 6-month clinical trial

2005 ◽  
Vol 32 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Suru Mankodi ◽  
Robert D. Bartizek ◽  
J. Leslie Winston ◽  
Aaron R. Biesbrock ◽  
Stephen F. McClanahan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sodium Hexametaphosphate ◽  
Stannous Fluoride

Randomized Trial of Silver Nitrate with Sodium Fluoride for Caries Arrest

2019 ◽  
Vol 4 (2) ◽  
pp. 126-134 ◽  
Author(s):  
S.S. Gao ◽  
D. Duangthip ◽  
M.C.M. Wong ◽  
E.C.M. Lo ◽  
C.H. Chu
Keyword(s):  
Clinical Trial ◽  
Preschool Children ◽  
Silver Nitrate ◽  
Randomized Clinical Trial ◽  
Sodium Fluoride ◽  
Silver Diamine Fluoride ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B

Objectives: The aim of this noninferiority double-blind randomized clinical trial was to compare the effectiveness of the topical semiannual application of a 25% silver nitrate (AgNO3) solution followed by a 5% sodium fluoride (NaF) varnish with that of a 38% silver diamine fluoride (SDF) solution in arresting caries among preschool children. Methods: Healthy 3-y-old children with active dentine carious lesions were randomly allocated to 2 groups via computer-generated random numbers. Lesions in group A received applications of a 25% AgNO3 solution followed by a 5% NaF varnish semiannually (every 6 mo). Lesions in group B received semiannual applications of a 38% SDF solution followed by a placebo varnish. A trained examiner recorded the status of caries and oral hygiene at baseline and during follow-up examinations. The examiner, children, and their caretakers were blinded to the intervention allocation. This study adopted an intention-to-treat analysis. A noninferiority test was conducted for the data analysis. Group A’s noninferiority was accepted if the lower limit of the 95% CI for the difference in the mean number of arrested surfaces was >−0.5. Results: A total of 1,070 children were recruited at baseline, with 535 children in each group. After 18 mo, the mean ± SD number of arrested surfaces was 3.3 ± 3.4 in group A (n = 484) and 3.2 ± 3.5 in group B (n = 476; P = 0.664). The difference in the mean number of arrested surfaces between the groups was 0.092 (95% CI, −0.322 to 0.505). Apart from black staining on the arrested lesions, no other significant side effect was observed. Conclusion: A semiannual application of 25% AgNO3 followed by 5% NaF is no worse than a 38% SDF in arresting dentine caries among preschool children over 18 mo. The Hong Kong Research Grants Council (GRF 17107315) funded this trial, which was registered at ClinicalTrials.gov (NCT02019160). Knowledge Transfer Statement: This randomized clinical trial found that silver nitrate solution followed by sodium fluoride varnish is effective in arresting dentine caries among preschool children. As silver nitrate followed by sodium fluoride is a noninvasive and simple protocol, it can be an alternative strategy to manage dental caries among young children, especially in countries where silver diamine fluoride is not available.

scholarly journals Effects of fluoride and calcium phosphate-based varnishes on pH, lactic acid, and trace elements in saliva: a randomized clinical trial.

2020 ◽  
Author(s):  
Andrea Poza Pascual ◽  
Clara Serna Muñoz ◽  
Amparo Perez Silva ◽  
Yolanda Martínez-Beneyto ◽  
Antonio Jose Ortiz Ruiz
Keyword(s):  
Clinical Trial ◽  
Trace Elements ◽  
Lactic Acid ◽  
Placebo Group ◽  
High Risk ◽  
Randomized Clinical Trial ◽  
Sodium Fluoride ◽  
Dental Tissue ◽  
High Caries Risk ◽  
Oral Environment

Abstract Background: When dental plaque is not regularly removed, bacteria break down sugars in the diet forming acids as by-products. Lactic acid is the main acid involved in caries. As acids accumulate minerals are lost from the surface layer of the tooth. The imbalance in demineralization/remineralization favors the loss of calcium and phosphate from the teeth. Saliva contains the most important microelements for the remineralization and maturation of dental tissue and plays a crucial role in maintaining the oral environment. Fluoride is the agent par excellence in preventing and detaining cavities. However, remineralization may be hampered by limited levels of calcium and phosphate, and new products have been developed to ensure a constant supply. The aim of this study was to investigate the effect of the application of two varnishes − MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP) – applied every three months in children with high caries risk for 12 months on salivary pH, lactic acid concentrations and trace elements.Methods: We conducted a controlled, randomized clinical trial where MI Varnish and Clinpro White Varnish were applied quarterly in children with a high risk of caries, for 12 months. We included 58 children aged 4-12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-monthly saliva samples were taken. We assessed changes in pH, lactic acid concentrations and trace elements in saliva. Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24Mg (p= <0.001), 31P (p = 0.033) and 66Zn (p= 0.005) levels in the placebo group (p≤0.05), but not in the other elements studied: 23Na, 27Al, 39K, 44Ca, 52Cr, 55Mn, 57Fe, 59Co, 63Cu, 75As, 111Cd, 137Ba, 208Pb and 19F. Conclusions: Neither pH, lactic acid concentrations or most salivary trace elements were useful in defining patients at high risk of caries or in monitoring the effect of MI Varnish and Clinpro White Varnish after three-monthly application for 12 months. Trial registration: ISRCTN registry, ISRCTN13681286. Registered 26 May 2020.

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