scholarly journals Effects of fluoride and calcium phosphate-based varnishes on pH, lactic acid, and trace elements in saliva: a randomized clinical trial.

2020 ◽  
Author(s):  
Andrea Poza Pascual ◽  
Clara Serna Muñoz ◽  
Amparo Perez Silva ◽  
Yolanda Martínez-Beneyto ◽  
Antonio Jose Ortiz Ruiz
Keyword(s):  
Clinical Trial ◽  
Trace Elements ◽  
Lactic Acid ◽  
Placebo Group ◽  
High Risk ◽  
Randomized Clinical Trial ◽  
Sodium Fluoride ◽  
Dental Tissue ◽  
High Caries Risk ◽  
Oral Environment

Abstract Background: When dental plaque is not regularly removed, bacteria break down sugars in the diet forming acids as by-products. Lactic acid is the main acid involved in caries. As acids accumulate minerals are lost from the surface layer of the tooth. The imbalance in demineralization/remineralization favors the loss of calcium and phosphate from the teeth. Saliva contains the most important microelements for the remineralization and maturation of dental tissue and plays a crucial role in maintaining the oral environment. Fluoride is the agent par excellence in preventing and detaining cavities. However, remineralization may be hampered by limited levels of calcium and phosphate, and new products have been developed to ensure a constant supply. The aim of this study was to investigate the effect of the application of two varnishes − MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP) – applied every three months in children with high caries risk for 12 months on salivary pH, lactic acid concentrations and trace elements.Methods: We conducted a controlled, randomized clinical trial where MI Varnish and Clinpro White Varnish were applied quarterly in children with a high risk of caries, for 12 months. We included 58 children aged 4-12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-monthly saliva samples were taken. We assessed changes in pH, lactic acid concentrations and trace elements in saliva. Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24Mg (p= <0.001), 31P (p = 0.033) and 66Zn (p= 0.005) levels in the placebo group (p≤0.05), but not in the other elements studied: 23Na, 27Al, 39K, 44Ca, 52Cr, 55Mn, 57Fe, 59Co, 63Cu, 75As, 111Cd, 137Ba, 208Pb and 19F. Conclusions: Neither pH, lactic acid concentrations or most salivary trace elements were useful in defining patients at high risk of caries or in monitoring the effect of MI Varnish and Clinpro White Varnish after three-monthly application for 12 months. Trial registration: ISRCTN registry, ISRCTN13681286. Registered 26 May 2020.

scholarly journals Effects of Fluoride and Calcium Phosphate-Based Varnishes on pH, Lactic Acid and Trace Elements in Saliva: A Randomized Clinical Trial.

2020 ◽  
Author(s):  
Andrea Poza Pascual ◽  
Clara Serna Muñoz ◽  
Amparo Perez Silva ◽  
Yolanda Martínez-Beneyto ◽  
Antonio Jose Ortiz Ruiz
Keyword(s):  
Clinical Trial ◽  
Trace Elements ◽  
Lactic Acid ◽  
Placebo Group ◽  
High Risk ◽  
Calcium Phosphate ◽  
Randomized Clinical Trial ◽  
Sodium Fluoride ◽  
Dental Tissue ◽  
Casein Phosphopeptide

Abstract Background: When dental plaque is not regularly removed, bacteria break down sugars in the diet forming acids as by-products. Lactic acid is the main acid involved in caries. As acids accumulate minerals are lost from the surface layer of the tooth. The imbalance in demineralization/remineralization favours the loss of calcium and phosphate from the teeth. Saliva contains the most important microelements for the remineralization and maturation of dental tissue and plays a crucial role in maintaining the oral environment. Fluoride is the agent par excellence in preventing and detaining cavities. However, remineralization may be hampered by limited levels of calcium and phosphate, and new products have been developed to ensure a constant supply. Two of the most used products are amorphous calcium phosphate stabilized with casein phosphopeptide (CPP-ACP) and tricalcium phosphate modified by fumaric acid (fTCP).Methods: We conducted a controlled, randomized clinical trial of the effect on the saliva of the application of two varnishes − MI Varnish (CPP-ACP with sodium fluoride 5%) and Clinpro White Varnish (fTCP with sodium fluoride 5%) – applied every three months in children with a high risk of caries, for 12 months. We included 58 children aged 4-12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-monthly saliva samples were taken. We assessed changes in pH, lactic acid concentrations and trace elements in saliva.Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24Mg, 31P and 66Zn levels in the placebo group (p≤0.05), but not in the other elements studied: 23Na, 27Al, 39K, 44Ca, 52Cr, 55Mn, 57Fe, 59Co, 63Cu, 75As, 111Cd, 137Ba, 208Pb and 19F.Conclusions: Neither pH, lactic acid concentrations or most salivary trace elements were useful in defining patients at high risk of caries or in monitoring the effect of MI Varnish and Clinpro White Varnish after three-monthly application for 12 months.Trial registration: ISRCTN13681286. Registered 26 May 2020 - Retrospectively registered, http://www.isrctn.com/ISRCTN13681286

scholarly journals Effects of Fluoride and Calcium Phosphate-Based Varnishes in Children at High Risk of Tooth Decay: A Randomized Clinical Trial

2021 ◽  
Vol 18 (19) ◽  
pp. 10049
Author(s):  
Andrea Poza-Pascual ◽  
Clara Serna-Muñoz ◽  
Amparo Pérez-Silva ◽  
Yolanda Martínez-Beneyto ◽  
Inmaculada Cabello ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Placebo Group ◽  
High Risk ◽  
Sodium Fluoride ◽  
Chemical Elements ◽  
The Other ◽  
Tooth Decay ◽  
Caries Risk ◽  
High Caries Risk ◽  
Salivary Ph

Background: The aim of this study was to investigate the effect of the application of two varnishes—MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP)—applied every three months in children with high caries risk for 12 months on plaque indexes, salivary pH, salivary lactic acid and chemical elements concentrations. Methods: We included 58 children aged 4–12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-month saliva samples were taken. We assessed changes in pH, lactic acid concentrations and chemical elements in saliva. Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24Mg (p = <0.001), 31P (p = 0.033) and 66Zn (p = 0.005) levels in the placebo group (p ≤ 0.05), but not in the other elements studied: 23Na, 27Al, 39K, 44Ca, 52Cr, 55Mn, 57Fe, 59Co, 63Cu, 75As, 111Cd, 137Ba, 208Pb and 19F. Conclusions: Neither pH, lactic acid concentrations or most salivary chemical elements were useful in defining patients at high risk of caries or in monitoring the effect of MI Varnish and Clinpro White Varnish after three-month application for 12 months. However, the appearance of new cavities was stopped, and the hygiene index improved, probably due to hygienic and dietary measures and the use of fluoridated toothpaste. Trial registration: ISRCTN registry, ISRCTN13681286.

scholarly journals THU0566 THE EFFECT OF KINESIO-TAPING ON CHRONIC NONSPECIFIC LOW BACK PAIN: PRELIMINARY RESULTS OF A DOUBLE BLINDED RANDOMIZED CLINICAL TRIAL.

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 524.1-525
Author(s):  
I. Aachari ◽  
K. Samia ◽  
T. Latifa ◽  
T. Fatima Zahrae ◽  
S. Afilal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Low Back Pain ◽  
Placebo Group ◽  
Back Pain ◽  
Randomized Clinical Trial ◽  
Clinical Characteristics ◽  
Functional Disability ◽  
Low Back ◽  
Kinesio Taping ◽  
Secondary Outcomes

Background:The technique of Kinesio-Taping is a method of adhesive bandage exerting traction on the skin which would favorably influence the muscular and articular systems by reducing the pressure exerted on the subcutaneous mechanoreceptors thus reducing pain and muscle tension.Objectives:The aim of this study is to assess the effectiveness of Kinesio-Taping in the short and medium term on pain and function in patients with chronic nonspecific low back pain compared to a placebo.Methods:We conducted a double-blind, two-arm randomized clinical trial. The study should include a total of 70 patients randomized into 2 groups: Kinesio-Taping (n = 35) and control group (n = 35). To this date we have included 46 patients.All patients receives four I-shaped adhesive strips arranged in a star-like shape and applied to the most painful region of the lower back with a tension between 25% to 30% in the taping group. The placebo group received a taping procedure with no tension.Taping is applied three times (at baseline, fourth and eighth day). Patients are assessed at baseline, on day 14 and at 4 weeks by the Arabic version of the Oswestry Physical and Functional Disability Index (ODI) which is the primary outcome. The secondary outcomes are the assessment of pain and functional disability according to the visual analog scale (VAS) evaluated on a scale of 0 to 10, as well as Rolland-Morris score.Results:Both groups were comparable at baseline concerning the demographical and clinical characteristics (P > 0.05) (table 1). The result of repeated measures ANOVA showed a significant change in ODI score and in VAS for pain and functional disability as well as Rolland-Morris score in both groups. Using the ANCOVA, controlling for pre-test scores, a significant difference was found between the two groups (table 2).Table 1. Clinical characteristics of study population.Conclusion:Our clinical trial offers preliminary evidence on the superiority of Kinesio-Taping in the treatment chronic back pain compared to placebo concerning the reduction of pain and disability. Thus, it can be used as a complementary method in chronic non-specific low back pain.Table 2. Primary and secondary outcomes in the Kinesio-Taping and placebo group.Disclosure of Interests:None declared

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