Anti-gingivitis efficacy of a stabilized 0.454% stannous fluoride/sodium hexametaphosphate dentifrice. A controlled 6-month clinical trial

2005 ◽  
Vol 32 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Suru Mankodi ◽  
Robert D. Bartizek ◽  
J. Leslie Winston ◽  
Aaron R. Biesbrock ◽  
Stephen F. McClanahan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sodium Hexametaphosphate ◽  
Stannous Fluoride

scholarly journals A Randomized Clinical Trial to Compare Plaque Inhibition of a Sodium Fluoride/Potassium Nitrate Dentifrice versus a Stabilized Stannous Fluoride/ Sodium Hexametaphosphate Dentifrice

2009 ◽  
Vol 10 (2) ◽  
pp. 1-9 ◽  
Author(s):  
Matthew L. Barker ◽  
Philip G. Bellamy ◽  
Nichelle Khera ◽  
Trevor N. Day ◽  
Andrew J. Mussett
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Sodium Fluoride ◽  
Potassium Nitrate ◽  
Dental Erosion ◽  
Positive Control ◽  
Sodium Hexametaphosphate ◽  
Double Blind ◽  
Plaque Area ◽  
Stannous Fluoride

Abstract Aim To compare the plaque inhibition efficacy of a sodium fluoride/potassium nitrate (NaF/KNO3 with 1450 ppm F) test dentifrice to a 0.454% stannous fluoride/sodium hexametaphosphate/sodium fluoride positive control dentifrice (SnF2/SHMP with 1450 ppm F). Methods and Materials Twenty-five subjects were randomized to a two-period, two-treatment, double blind crossover sequence using NaF/KNO3 (Sensodyne® ProNamel™ dentifrice) and SnF2/SHMP (blend-a-med®* EXPERT GUMS PROTECTION dentifrice). Each treatment was conducted with a standard manual toothbrush (Oral-B® P35 Indicator). Digital plaque image analysis (DPIA) was used on three consecutive days to evaluate: (a) overnight plaque formation (A.M. pre-brushing); (b) following 40 seconds of brushing with the test product (A.M. post-brushing); and (c) mid-afternoon (P.M.). Images were analysed using an objective computer algorithm to calculate the total area of visible plaque. A four-day washout period was instituted for the crossover phase. Results All 25 subjects completed the study. The SnF2/SHMP positive control dentifrice provided statistically significantly lower levels of plaque area coverage versus the NaF/KNO3 test dentifrice at each timepoint. For the SnF2/SHMP dentifrice, plaque coverage was 23.0% lower (p<0.0001) at A.M. pre-brushing, 17.3% (p=0.0163) lower at A.M. post-brushing, and 22.6% (p= 0.0004) lower at the P.M. measure relative to the NaF/KNO3 dentifrice. Conclusion The SnF2/SHMP dentifrice (blend-a-med® EXPERT GUMS PROTECTION) inhibits plaque regrowth both overnight and during the day to a significantly greater degree than the NaF/KNO3 dentifrice (Sensodyne® ProNamel™). Clinical Significance Dentists recommending an effective home use dentifrice for patients experiencing dentinal hypersensitivity and/or dental erosion may previously have needed to compromise on other key benefits, such as plaque control. blend-a-med® EXPERT GUMS PROTECTION is a dentifrice when integrated into an oral hygiene routine can provide a proven treatment for hypersensitivity, dental erosion, and a reduction in the regrowth of plaque. Citation Bellamy PG, Khera N, Day TN, Barker ML, Mussett AJ. A Randomized Clinical Trial to Compare Plaque Inhibition of a Sodium Fluoride/Potassium Nitrate Dentifrice versus a Stabilized Stannous Fluoride/ Sodium Hexametaphosphate Dentifrice. J Contemp Dent Pract 2009 March; (10)2:001-009. * Also branded Crest® and Ipana, depending on the country.

An Anticalculus Dentifrice with Sodium Hexametaphosphate and Stannous Fluoride: A Six-month Study of Efficacy

2007 ◽  
Vol 8 (5) ◽  
pp. 1-8 ◽  
Author(s):  
J. Leslie Winston ◽  
Thomas Schiff ◽  
Susan K. Fiedler ◽  
Robert A. Baker
Keyword(s):  
Soft Tissue ◽  
Home Care ◽  
Clinical Significance ◽  
Negative Control ◽  
Sodium Hexametaphosphate ◽  
Control Group ◽  
Stannous Fluoride ◽  
Parallel Group ◽  
Calculus Formation ◽  
Oral Soft Tissue

Abstract Aim To compare the anticalculus efficacy of an experimental dentifrice (0.454% stabilized stannous fluoride/ sodium hexametaphosphate) with a negative control. Methods and Materials This was a randomized, examiner-blind, parallel group study. After a three-month run-in, qualifying subjects were randomized to the experimental or control dentifrice to use twice a day for six months. Volpe-Manhold Index (V-MI) and oral soft tissue examinations were conducted at baseline, three, and six months. Additional analyses were performed separately at three and six months on three subgroups categorized into high, medium, and low calculus-forming subjects. Results Compared to the control group, the experimental dentifrice group had a mean calculus score statistically significantly lower at both three months (50%) and six months (55%) post-treatment (p<0.001). Compared to control scores, mean experimental dentifrice calculus scores at three and six months were statistically significantly lower at both points in time for high, medium, and low calculus forming sub-groups (p<0.001). Both products were generally well tolerated. Conclusion The experimental dentifrice revealed significant anticalculus efficacy compared to the control regardless of levels of baseline calculus formation. Clinical Significance The stannous fluoride/sodium hexametaphosphate dentifrice technology is an effective calculus inhibitor for home care. Citation Winston JL, Fiedler SK, Schiff T, Baker RA. An Anticalculus Dentifrice with Sodium Hexametaphosphate and Stannous Fluoride: A Six-month Study of Efficacy. J Contemp Dent Pract 2007 July;(8)5:001-008.

scholarly journals Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice

2019 ◽  
Vol 17 (3) ◽  
pp. 261-267 ◽  
Author(s):  
Nicola X. West ◽  
Tao He ◽  
Nikki Hellin ◽  
Nicholas Claydon ◽  
Joon Seong ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Stannous Fluoride ◽  
Protection Efficacy ◽  
Fluoride Dentifrice ◽  
Erosion Protection

scholarly journals A 24-Hour Dental Plaque Prevention Study with a Stannous Fluoride Dentifrice Containing Hexametaphosphate

2006 ◽  
Vol 7 (3) ◽  
pp. 1-11 ◽  
Author(s):  
Donald J. White ◽  
Kathy M. Kozak ◽  
Roger D. Gibb ◽  
John M. Dunavent ◽  
Malgorzata Klukowska ◽  
...  
Keyword(s):  
Treatment Period ◽  
Treatment Regimen ◽  
Sodium Fluoride ◽  
Dental Plaque ◽  
Plaque Formation ◽  
Sodium Hexametaphosphate ◽  
Prevention Study ◽  
Stannous Fluoride ◽  
Intervention Protocol ◽  
Fluoride Dentifrice

Abstract Recently, a novel antibacterial fluoride dentifrice containing stannous fluoride and sodium hexametaphosphate (Crest® PRO-HEALTH™) was introduced. A digital plaque image analysis (DPIA) technique was used to quantify in situ plaque formation in a population carrying out a phased intervention protocol that included: (1) an initial treatment regimen including toothbrushing with standard sodium fluoride dentifrice in conventional bid brushing, (2) a second treatment regimen where a modified hygiene regimen was applied using standard sodium fluoride dentifrice including a period of 24 hours of non-brushing, and (3) a third treatment regimen where the 24-hour non-brushing regimen was continued using the antimicrobial stannous fluoride/sodium hexametaphosphate dentifrice. The quantitative evaluation of plaque formation was assessed in morning measurements following either standard evening hygiene (treatment period 1) or 24 hours since brushing (treatment periods 2 and 3). Post-brushing plaque measurements were also taken in each treatment regimen. Sixteen subjects completed all three treatment regimens with no side effects or oral complaints. Morning plaque coverage in treatment period 1 was 13.3%. Plaque coverage significantly increased in treatment period 2 when pre-bedtime brushing was discontinued, with 24-hour growth covering 18.4% of the dentition. Intervention of the antimicrobial stannous fluoride/hexametaphosphate dentifrice in treatment period 3 provided significant inhibition of plaque regrowth over 24 hours (15.2% coverage, a 17% reduction vs. sodium fluoride dentifrice control). These results support the strong retention and lasting antimicrobial efficacy of high stabilized stannous fluoride/sodium hexametaphosphate dentifrices. Citation White DJ, Kozak KM, Gibb RD, Dunavent JM. A 24-Hour Dental Plaque Prevention Study with a Stannous Fluoride Dentifrice Containing Hexametaphosphate. J Contemp Dent Pract 2006 July;(7)3:001-011.

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