scholarly journals Expression of the oestrogen regulated pNR-2 mRNA in human breast cancer: relation to oestrogen receptor mRNA levels and response to tamoxifen therapy

1990 ◽  
Vol 61 (1) ◽  
pp. 32-38 ◽  
Author(s):  
JA Henry ◽  
S Nicholson ◽  
C Hennessy ◽  
TWJ Lennard ◽  
FEB May ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Tamoxifen Therapy ◽  
Mrna Levels ◽  
Human Breast ◽  
Receptor Mrna

Inverse Relationship Between Estrogen Receptor and Epidermal Growth Factor Receptor mRNA Levels in Human Breast Cancer Cell Lines

1990 ◽  
Vol 3 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Christine S. L. Lee ◽  
Rosemary E. Hall ◽  
Ian E. Alexander ◽  
Masafumi Koga ◽  
John Shine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Inverse Relationship ◽  
Growth Factor Receptor ◽  
Human Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Mrna Levels ◽  
Human Breast ◽  
Receptor Mrna ◽  
Epidermal Growth

scholarly journals Oestrogen receptors and antioestrogen treatment of hormone-dependent tumours

2018 ◽  
Vol 49 (2) ◽  
pp. 91
Author(s):  
N. G. KOSTOMITSOPOULOS (Ν.Γ. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ)
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Dna Sequences ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Specific Gene ◽  
Oestrogen Receptors ◽  
Human Breast ◽  
Potential Use

The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences. The study of the role of oestrogen receptor on the expression of the mitogenic actionof oestrogens and oncogenesis lead biomedical research in new approaches of the treatment of oestrogen-dependent tumors by using antioestrogens. Main mechanism of action of antioestrogens is the prevention of oestrogen action by blocking the binding of oestradiol to the oestrogen receptor. Tamoxifen, the most wellknown antioestrogen, is widely used as adjuvant therapy in all stages of human breast cancer. Recently interest is focused on the potential use of "pure" antioestrogens. The use of antioestrogens in veterinary oncology is also under discussion.

Estrogen Activities and the Cellular Effects of Natural Progesterone from Wild Yam Extract in MCF-7 Human Breast Cancer Cells

2009 ◽  
Vol 37 (01) ◽  
pp. 159-167 ◽  
Author(s):  
Mi-Kyung Park ◽  
Hyeok-Yi Kwon ◽  
Woong-Shick Ahn ◽  
Sumi Bae ◽  
Mee-Ra Rhyu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Estrogenic Activity ◽  
Mrna Levels ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Wild Yam ◽  
Mcf 7

We studied the estrogenic activity and cellular effect of wild yam extract in MCF-7 human breast cancer cells. The extract increased the activity of the progesterone receptor and pS2 genes at the mRNA levels in human breast cancer MCF-7 cells, although the effects were not as prominent as those of 17β-estradiol (E2). Western blot analysis showed that the level of estrogen receptor α protein was down-regulated after treatment with E2 or wild yam extract. Wild yam extract also inhibited proliferation of MCF-7 cells. These data indicate that wild yam extract acts as a weak phytoestrogen and protects against proliferation in human breast carcinoma MCF-7 cells.

Interactions between MAP kinase and oestrogen receptor in human breast cancer

2013 ◽  
Vol 49 (6) ◽  
pp. 1176-1186 ◽  
Author(s):  
Liane M. McGlynn ◽  
Sian Tovey ◽  
John M.S. Bartlett ◽  
Julie Doughty ◽  
Timothy G. Cooke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Map Kinase ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Human Breast

Modulation of Bcl-2 and Ki-67 expression in oestrogen receptor-positive human breast cancer by tamoxifen

1994 ◽  
Vol 30 (11) ◽  
pp. 1663-1669 ◽  
Author(s):  
S.R.D. Johnston ◽  
K.A. MacLennan ◽  
N.P.M. Sacks ◽  
J. Salter ◽  
I.E. Smith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Human Breast ◽  
Ki 67

Low-level lasers on microRNA and uncoupling protein 2 mRNA levels in human breast cancer cells

Laser Physics ◽  
2017 ◽  
Vol 27 (6) ◽  
pp. 065601 ◽  
Author(s):  
K S Canuto ◽  
A F Teixeira ◽  
J A Rodrigues ◽  
F Paoli ◽  
E M Nogueira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Mrna Levels ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Low Level
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