scholarly journals Coadministration of nanosystems of short silencing RNAs targeting oestrogen receptor α and anti-oestrogen synergistically induces tumour growth inhibition in human breast cancer xenografts

2009 ◽  
Vol 122 (1) ◽  
pp. 145-158 ◽  
Author(s):  
Céline Bouclier ◽  
Véronique Marsaud ◽  
Olivia Bawa ◽  
Valérie Nicolas ◽  
Laurence Moine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Inhibition ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Tumour Growth ◽  
Human Breast ◽  
Tumour Growth Inhibition ◽  
Oestrogen Receptor Α ◽  
Breast Cancer Xenografts

P16 Biological profiles of two ERBB2-amplified human breast cancer xenografts diversely sensitive to Trastuzumab

2007 ◽  
Vol 5 (8) ◽  
pp. 23
Author(s):  
L. de Plater ◽  
E. Marangoni ◽  
F. Assayag ◽  
N. Auger ◽  
A. Degeorges ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Breast Cancer Xenografts

scholarly journals Oestrogen receptors and antioestrogen treatment of hormone-dependent tumours

2018 ◽  
Vol 49 (2) ◽  
pp. 91
Author(s):  
N. G. KOSTOMITSOPOULOS (Ν.Γ. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ)
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Dna Sequences ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Specific Gene ◽  
Oestrogen Receptors ◽  
Human Breast ◽  
Potential Use

The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences. The study of the role of oestrogen receptor on the expression of the mitogenic actionof oestrogens and oncogenesis lead biomedical research in new approaches of the treatment of oestrogen-dependent tumors by using antioestrogens. Main mechanism of action of antioestrogens is the prevention of oestrogen action by blocking the binding of oestradiol to the oestrogen receptor. Tamoxifen, the most wellknown antioestrogen, is widely used as adjuvant therapy in all stages of human breast cancer. Recently interest is focused on the potential use of "pure" antioestrogens. The use of antioestrogens in veterinary oncology is also under discussion.

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