scholarly journals Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer

2017 ◽  
Vol 117 (8) ◽  
pp. 1176-1184 ◽  
Author(s):  
Mohammed A Aleskandarany ◽  
Sultan Sonbul ◽  
Rachel Surridge ◽  
Abhik Mukherjee ◽  
Carlos Caldas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Rho Gtpase ◽  
Good Prognosis ◽  
Gtpase Activating Protein

scholarly journals Differential expression of Rho GTPase-activating protein 20 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Rho Gtpase ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Gtpase Activating Protein ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding Rho GTPase-activating protein 20, ARHGAP20, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ARHGAP20 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ARHGAP20 in primary tumors of the breast was correlated with overall survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ARHGAP20 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

CD61+ and CAF+ were found to be good prognosis factors for invasive breast cancer patients

2017 ◽  
Vol 213 (10) ◽  
pp. 1296-1301 ◽  
Author(s):  
Dongyan Cai ◽  
Xiaohong Wu ◽  
Tingting Hong ◽  
Yong Mao ◽  
Xiaosong Ge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Breast Cancer ◽  
Good Prognosis ◽  
Breast Cancer Patients ◽  
Prognosis Factors

scholarly journals IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients

2017 ◽  
Vol 67 (4) ◽  
pp. 537-549 ◽  
Author(s):  
Narmeen Ahmad ◽  
Aula Ammar ◽  
Sarah J. Storr ◽  
Andrew R. Green ◽  
Emad Rakha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Breast Cancer ◽  
Early Stage ◽  
Good Prognosis ◽  
Breast Cancer Patients

scholarly journals ARHGAP15 expression associates with survival in triple negative breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rho Gtpase ◽  
Molecular Subtype ◽  
Breast Cancer Patients ◽  
Gtpase Activating Protein ◽  
Primary Tumors ◽  
Significant Gene

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of Rho GTPase activating protein 15, encoded by ARHGAP15 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, ARHGAP15 expression was correlated with overall survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. ARHGAP15 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.

scholarly journals Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes

2018 ◽  
Vol 118 (8) ◽  
pp. 1142-1151 ◽  
Author(s):  
Chitra Joseph ◽  
Olivia Macnamara ◽  
Madeleine Craze ◽  
Roslin Russell ◽  
Elena Provenzano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Good Prognosis ◽  
Mediator Complex

Overexpression of Certain Cancer Stem Cell Marker Confer A Good Prognosis In Invasive Breast Cancer

2019 ◽  
Vol 45 (11) ◽  
pp. 2220
Author(s):  
Umar Wazir ◽  
Mona Orakzai ◽  
Tracey Martin ◽  
Salim Tayeh ◽  
Wen Guo Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Invasive Breast Cancer ◽  
Good Prognosis ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Stratification Using hTERT and Stem Cell Markers Confers a Good Prognosis in Invasive Breast Cancer

2020 ◽  
Vol 17 (2) ◽  
pp. 169-174
Author(s):  
UMAR WAZIR ◽  
SALIM TAYEH ◽  
MONA A.W. ORAKZAI ◽  
TRACEY A. MARTIN ◽  
WEN G. JIANG ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Invasive Breast Cancer ◽  
Good Prognosis ◽  
Stem Cell Markers ◽  
Cell Markers

scholarly journals Differential expression of Rho GTPase activating protein 10 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Rho Gtpase ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Gtpase Activating Protein ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding Rho GTPase activating protein 10, ARHGAP10, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ARHGAP10 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ARHGAP10 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. ARHGAP10 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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