Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects

1981 ◽  
Vol 29 (3) ◽  
pp. 318-321 ◽  
Author(s):  
William E Mitch ◽  
Michael W Johnson ◽  
James M Kirshenbaum ◽  
Robert E Lopez
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
Normal Subjects ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Oral Doses

scholarly journals Uric Acid Excretion in Patients with Malignant Lymphomas

Blood ◽  
1961 ◽  
Vol 17 (6) ◽  
pp. 701-718 ◽  
Author(s):  
N. PRIMIKIRIOS ◽  
L. STUTZMAN ◽  
A. A. SANDBERG
Keyword(s):  
Uric Acid ◽  
Normal Subjects ◽  
Response To Treatment ◽  
Blood Levels ◽  
Acid Excretion ◽  
Malignant Lymphomas ◽  
Uric Acid Excretion ◽  
Blood Uric Acid ◽  
Objective Clinical Response ◽  
Uric Acid Nephropathy

Abstract Uric acid blood and urine studies were performed in 12 patients with lymphomas while on a measured low purine diet before, during and after cytotoxic therapy. Before treatment, urinary uric acid excretion in these patients was significantly higher than in normal subjects, although only 2 patients had clearly elevated blood uric acid levels. There was no correlation between the estimated size of the tumor masses and pretreatment uric acid excretion. The response to treatment could not have been predicted by measurement of the pretreatment uric acid excretion. In one patient with extensive tumor infiltration of the kidneys, dangerous renal failure, preceded by marked hyperuricemia, developed during therapy. Mechanical hemodialysis resulted in clinical improvement and marked reduction in the blood levels of uric acid and urea. The finding of a large increase in uric acid excretion during the early days of treatment of a patient with lymphoma is indicative of a responsive tumor. Such data also serve as warning of potential obstructive uric acid nephropathy or uropathy before major increases in serum uric acid appear. Small increases of uric acid excretion in association with treatment could not be correlated with objective clinical response.

scholarly journals Studies on Leukemia

Blood ◽  
1956 ◽  
Vol 11 (2) ◽  
pp. 154-166 ◽  
Author(s):  
A. A. SANDBERG ◽  
G. E. CARTWRIGHT ◽  
M. M. WINTROBE
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Leukocyte Count ◽  
Normal Subjects ◽  
Lymphocytic Leukemia ◽  
Chronic Myelocytic Leukemia ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Myelocytic Leukemia ◽  
The Mean

Abstract 1. The urinary excretion of uric acid was studied in 17 normal subjects and in 38 patients with leukemia. The mean excretion of uric acid by the normal subjects was 6.5 mg./Kg. of body weight /24 hrs. The mean excretion of uric acid in 14 patients with acute lymphoblastic leukemia was 30.3 mg./Kg. /24 hrs.; in 13 patients with acute myeloblastic leukemia, 13.0 mg.; in 6 patients with chronic lymphocytic leukemia, 5.2 mg.; and in 5 patients with chronic myelocytic leukemia, 13.5 mg. 2. Following therapy with cortisone, 6-mercaptopurine or Amethopterin, the urinary excretion of uric acid increased in the cases of acute leukemia as the leukocyte count declined. As the leukocyte count approached normal levels, the uric acid excretion decreased. The urinary excretion of xanthine and guanine paralleled the excretion of uric acid. 3. In association with the administration of an aromatic nitrogen mustard derivative to one patient with chronic lymphocytic leukemia and Myleran to one patient with chronic myelocytic leukemia, there was only a slight increase in uric acid excretion.

Effect of urine flow rate on uric acid excretion in man

1972 ◽  
Vol 15 (4) ◽  
pp. 338-346 ◽  
Author(s):  
Herbert S. Diamond ◽  
Robert Lazarus ◽  
David Kaplan ◽  
David Halberstam
Keyword(s):  
Uric Acid ◽  
Flow Rate ◽  
Urine Flow ◽  
Urine Flow Rate ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals Effect of pentose ingestion on uric acid excretion

1929 ◽  
Vol 23 (6) ◽  
pp. 1175-1177
Author(s):  
Kate Madders ◽  
Robert Alexander McCance
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals POS1144 SERUM URIC ACID TO CREATININE RATIO IS ASSOCIATED WITH URINARY URIC ACID EXCRETION IN PATIENTS WITH GOUT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 851.2-851
Author(s):  
Z. Zhong ◽  
Y. Huang ◽  
X. Huang ◽  
Q. Huang ◽  
Y. Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Output ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Binary Logistic Regression Analysis ◽  
Creatinine Ratio ◽  
Acid Excretion ◽  
Complete Collection ◽  
Uric Acid Excretion

Background:Underexcretion of uric acid is the dominant mechanism leading to hyperuricemia [1] and the 24-hour urinary uric acid excretion is an important measurement. However, it is inconvenient due to accurate timing and complete collection of the specimen.Objectives:The aim of this study was to investigate the relationship between serum uric acid to creatinine ratio (sUACR) and 24-hour urinary uric acid excretion in gout patients.Methods:A total of 110 gout patients fulfilling 2015 ACR/EULAR classification criteria from Guangdong Second Provincial General Hospital from January 2019 to January 2021 were retrospectively enrolled in this study. Patients were divided into underexcretion group (<3600 μmol/24h) and non-underexcretion group (≥3600 μmol/24h). The correlation between sUACR and 24-hour urinary uric acid excretion was analyzed by the Pearson’s correlations analysis. Receiver operation characteristic (ROC) curves were performed to assess the utility of sUACR for discriminating between underexcretion group and non-underexcretion group. Furthermore, the risk factors of uric acid underexcretion were evaluated using binary logistic regression analysis.Results:sUACR in the underexcretion group was significantly lower than the non-underexcretion group (p=0.0001). Besides, sUACR was positively correlated with 24-hour urinary uric acid excretion (r=0.4833, p<0.0001). Furthermore, ROC suggested that the area under the curve (AUC) of sUACR was 0.728, which was higher that of serum uric acid and creatinine. The optimal cutoff point of sUACR was 5.2312, with a sensitivity and specificity of 71.9% and 67.9%. Logistic analysis results revealed that decreased sUACR (<5.2312) was an independent risk factor of underexcretion of uric acid (OR =5.510, 95% CI: 1.952-15.550, P=0.001).Conclusion:sUACR is lower in gout patients with underexcretion of uric acid and may serve as a useful and convenient marker of assessing underexcretion of uric acid in gout patients.References:[1]Perez-Ruiz F, Calabozo M, Erauskin GG, Ruibal A, Herrero-Beites AM. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum 2002; 47: 610–13.Figure 1.A. Comparison of serum uric acid to creatinine ratio between underexcretion group and non-underexcretion group. B. Correlation between serum uric acid to creatinine ratio and 24h uric acid excretion.Disclosure of Interests:None declared.

Uric acid excretion in normal children

1978 ◽  
Vol 92 (6) ◽  
pp. 911-914 ◽  
Author(s):  
F. Bruder Stapleton ◽  
Michael A. Linshaw ◽  
Khatab Hassanein ◽  
Alan B. Gruskin
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Normal Children ◽  
Uric Acid Excretion
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