scholarly journals Studies on Leukemia

Blood ◽  
1956 ◽  
Vol 11 (2) ◽  
pp. 154-166 ◽  
Author(s):  
A. A. SANDBERG ◽  
G. E. CARTWRIGHT ◽  
M. M. WINTROBE
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Leukocyte Count ◽  
Normal Subjects ◽  
Lymphocytic Leukemia ◽  
Chronic Myelocytic Leukemia ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Myelocytic Leukemia ◽  
The Mean

Abstract 1. The urinary excretion of uric acid was studied in 17 normal subjects and in 38 patients with leukemia. The mean excretion of uric acid by the normal subjects was 6.5 mg./Kg. of body weight /24 hrs. The mean excretion of uric acid in 14 patients with acute lymphoblastic leukemia was 30.3 mg./Kg. /24 hrs.; in 13 patients with acute myeloblastic leukemia, 13.0 mg.; in 6 patients with chronic lymphocytic leukemia, 5.2 mg.; and in 5 patients with chronic myelocytic leukemia, 13.5 mg. 2. Following therapy with cortisone, 6-mercaptopurine or Amethopterin, the urinary excretion of uric acid increased in the cases of acute leukemia as the leukocyte count declined. As the leukocyte count approached normal levels, the uric acid excretion decreased. The urinary excretion of xanthine and guanine paralleled the excretion of uric acid. 3. In association with the administration of an aromatic nitrogen mustard derivative to one patient with chronic lymphocytic leukemia and Myleran to one patient with chronic myelocytic leukemia, there was only a slight increase in uric acid excretion.

scholarly journals Studies on the Pseudouridinuria of Chronic Lymphocytic Leukemia

Blood ◽  
1964 ◽  
Vol 24 (5) ◽  
pp. 567-576 ◽  
Author(s):  
MARVIN LEWIS ◽  
SHERMAN M. WEISSMAN ◽  
MYRON KARON
Keyword(s):  
Uric Acid ◽  
Chronic Lymphocytic Leukemia ◽  
Chemical Analysis ◽  
Orotic Acid ◽  
Lymphocytic Leukemia ◽  
Major Portion ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Selective Retention

Abstract This paper reports a group of investigations attempting to explain the elevated pseudouridine excretion in the presence of normal uric acid excretion which occurs in chronic lymphocytic leukemia (CLL). Studies with isotopically labeled uric acid and adenine indicated that diversion of body purines from uric acid does not occur. Similarly the chemical analysis of the white cells in CLL did not reveal any excess content of pyrimidines, nor did the turnover of the ribonucleotides show any selective retention of purines as compared with pyrimidines. Studies with isotopically labeled orotic acid, however, indicated on overproduction of other pyrimidines as well as pseudouridine. Though no explanation has yet been found for the selective pyrimidine overproduction seen in CLL, a major portion of these pyrimidines appear to be derived from rapidly renewing sources.

THE EFFECT OF EPHEDRINE ON THE EXCRETION OF REDUCING STEROIDS, 17-KETOSTEROIDS AND URIC ACID IN HEALTHY MEN

1952 ◽  
Vol 8 (1) ◽  
pp. 27-31 ◽  
Author(s):  
BARBARA M. BRAY ◽  
W. H. H. MERIVALE ◽  
D. R. C. WILLCOX
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Inverse Relationship ◽  
Control Period ◽  
Acid Excretion ◽  
Normal Range ◽  
Healthy Men ◽  
Uric Acid Excretion ◽  
Upper Limit ◽  
Consistent Change

The urinary excretion in five healthy men of 17-ketosteroids, reducing steroids, uric acid and creatinine was studied for a 3-day control period, a period of 2 days during which 6 grains (390 mg.) of ephedrine were given by mouth, and for 1 day immediately thereafter. In all five men the excretion of reducing steroids rose to levels outside the normal range on one of the days on which ephedrine was given. There was an abrupt return to normal, even in the men who showed the increased excretion, on the first day of the administration of ephedrine. In two men 17-ketosteroid excretion rose above the upper limit of normal, but in two others there was no significant alteration, while in one the 17-ketosteroid excretion bore an inverse relationship to that of the reducing steroids. No consistent change occurred in the uric acid excretion.

Effect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken

1960 ◽  
Vol 198 (3) ◽  
pp. 575-580 ◽  
Author(s):  
Lawrence Berger ◽  
T'sai Fan Yü ◽  
Alexander B. Gutman
Keyword(s):  
Uric Acid ◽  
Tubular Secretion ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Acid Clearance ◽  
Uric Acid Clearance ◽  
Tubular Transport ◽  
Renal Tubular Transport ◽  
The Mean ◽  
Renal Tubular

In 43 chickens, the mean Cinulin was 4.7 ± 1.8 ml/min. (1.8 ± 0.8 ml/kg/min.), mean Curate 29.0 ± 14.9 ml/min. (11.3 ± 6.0 ml/kg/min.) and mean Turate 1.30 ± 0.69 mg/min. (0.48 ± 0.24 mg/kg/min.). Tubular secretion accounted for a mean of 81% of the total urinary urate. Probenecid, sulfinpyrazone, zoxazolamine and high dosages of phenylbutazone, all uricosuric in man, reduced urate excretion in the chicken, apparently by suppressing tubular secretion of urate; CPAH also was reduced. Salicylate, in doses uricosuric in man, had no effect on chicken urate excretion. Pyrazinamide and sodium r-lactate, agents which decrease urate excretion in man, did not alter urate excretion in the chicken. PAH loading experiments demonstrated that as TPAH increased, Turate decreased. These latter findings suggest competition of urate and PAH for renal tubular transport in the chicken.

scholarly journals The Plasma Clearance and Urinary Excretion of Parenterally Administered 58Co B12

Blood ◽  
1956 ◽  
Vol 11 (1) ◽  
pp. 31-43 ◽  
Author(s):  
D. L. MOLLIN ◽  
W. R. PITNEY ◽  
S. J. BAKER ◽  
J. E. BRADLEY
Keyword(s):  
Urinary Excretion ◽  
Vitamin B12 ◽  
Plasma Clearance ◽  
Vitamin B12 Deficiency ◽  
Normal Subjects ◽  
Normal Serum ◽  
Chronic Myelocytic Leukemia ◽  
Intravenous Injections ◽  
Myelocytic Leukemia ◽  
B12 Deficiency

Abstract Intravenous injections of 1.5 µg. of 58Co B12 were given to subjects with normal serum B12 concentrations, to patients with vitamin B12 deficiency and to patients with chronic myelocytic leukemia. The rate of plasma clearance of radioactivity after this dose was slowest in patients with chronic myelocytic leukemia and patients with pernicious anemia in severe relapse. In patients with vitamin B12 deficiency, serum B12 concentrations were estimated microbiologically at frequent intervals after the injection. There was a good correlation between the results obtained by microbiological assay and as calculated from plasma radioactivity. Significant differences were not observed between the urinary excretion of radioactivity by normal subjects and patients with B12 deficiency.

scholarly journals Uric Acid Excretion in Patients with Malignant Lymphomas

Blood ◽  
1961 ◽  
Vol 17 (6) ◽  
pp. 701-718 ◽  
Author(s):  
N. PRIMIKIRIOS ◽  
L. STUTZMAN ◽  
A. A. SANDBERG
Keyword(s):  
Uric Acid ◽  
Normal Subjects ◽  
Response To Treatment ◽  
Blood Levels ◽  
Acid Excretion ◽  
Malignant Lymphomas ◽  
Uric Acid Excretion ◽  
Blood Uric Acid ◽  
Objective Clinical Response ◽  
Uric Acid Nephropathy

Abstract Uric acid blood and urine studies were performed in 12 patients with lymphomas while on a measured low purine diet before, during and after cytotoxic therapy. Before treatment, urinary uric acid excretion in these patients was significantly higher than in normal subjects, although only 2 patients had clearly elevated blood uric acid levels. There was no correlation between the estimated size of the tumor masses and pretreatment uric acid excretion. The response to treatment could not have been predicted by measurement of the pretreatment uric acid excretion. In one patient with extensive tumor infiltration of the kidneys, dangerous renal failure, preceded by marked hyperuricemia, developed during therapy. Mechanical hemodialysis resulted in clinical improvement and marked reduction in the blood levels of uric acid and urea. The finding of a large increase in uric acid excretion during the early days of treatment of a patient with lymphoma is indicative of a responsive tumor. Such data also serve as warning of potential obstructive uric acid nephropathy or uropathy before major increases in serum uric acid appear. Small increases of uric acid excretion in association with treatment could not be correlated with objective clinical response.

Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects

1981 ◽  
Vol 29 (3) ◽  
pp. 318-321 ◽  
Author(s):  
William E Mitch ◽  
Michael W Johnson ◽  
James M Kirshenbaum ◽  
Robert E Lopez
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
Normal Subjects ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Oral Doses

Urinary Purine Excretion in the X-Irradiated Dog

1957 ◽  
Vol 189 (2) ◽  
pp. 315-322 ◽  
Author(s):  
Kenneth Jackson ◽  
Cecil Entenman
Keyword(s):  
Uric Acid ◽  
Radiation Dose ◽  
Ion Exchange ◽  
Urinary Excretion ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Whole Body ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
X Irradiation

Urinary excretion of purine bases by the dog following whole-body x-irradiation was studied. Ion exchange chromatography with Dowex-50 was used to measure uric acid, xanthine, hypoxanthine, guanine, 7-methylguanine and adenine. Changes in the excretion of uric acid and xanthine were noted during the first 24 hours following irradiation. Uric acid excretion was increased following doses between 150 and 500 r. Xanthine excretion increased markedly following superlethal doses but not after midlethal doses. Total purine excretion (allantoin plus uric acid) was increased slightly following irradiation and the degree of the increase was not related to the radiation dose.

A COMPARISON OF TWO METHODS FOR MEASUREMENT OF ALDOSTERONE SECRETION RATE IN MAN

1966 ◽  
Vol 53 (2) ◽  
pp. 177-188 ◽  
Author(s):  
P. Lund-Johansen ◽  
T. Thorsen ◽  
K. F. Støa
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Secretion Rate ◽  
Aldosterone Secretion ◽  
Simple Method ◽  
Mean Values ◽  
Pathological Conditions ◽  
Significant Difference ◽  
Derivative Method ◽  
The Mean

ABSTRACT A comparison has been made between (A), a relatively simple method for the measurement of aldosterone secretion rate, based on paper chromatography and direct densitometry of the aldosterone spot and (B) a more elaborate isotope derivative method. The mean secretion rate in 9 normal subjects was 112 ± 26 μg per 24 hours (method A) and 135 ± 35 μg per 24 hours (method B). The »secretion rate« in one adrenalectomized subject after the intravenous injection of 250 μg of aldosterone was 230 μg per 24 hours (method A) and 294 μg per 24 hours (method B). There was no significant difference in the mean values, and correlation between the two methods was good (r = 0.80). It is concluded that the densitometric method is suitable for clinical purposes as well as research, being more rapid and less expensive than the isotope derivative method. Method A also measures the urinary excretion of the aldosterone 3-oxo-conjugate, which is of interest in many pathological conditions. The densitometric method is obviously the less sensitive and a prerequisite for its use is an aldosterone secretion of 20—30 μg per 24 hours. Lower values are, however, rare in adults.

Effect of urine flow rate on uric acid excretion in man

1972 ◽  
Vol 15 (4) ◽  
pp. 338-346 ◽  
Author(s):  
Herbert S. Diamond ◽  
Robert Lazarus ◽  
David Kaplan ◽  
David Halberstam
Keyword(s):  
Uric Acid ◽  
Flow Rate ◽  
Urine Flow ◽  
Urine Flow Rate ◽  
Acid Excretion ◽  
Uric Acid Excretion
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