Prediction of sotalol-induced maximum steady-state QTc prolongation from single-dose administration in healthy volunteers

1992 ◽  
Vol 52 (4) ◽  
pp. 417-426 ◽  
Author(s):  
Franck Le Coz ◽  
Christian Funck-Brentano ◽  
Jean-Marie Poirier ◽  
Yves Kibleur ◽  
François Xavier Mazoit ◽  
...  
Keyword(s):  
Single Dose ◽  
Steady State ◽  
Healthy Volunteers ◽  
Qtc Prolongation ◽  
Dose Administration ◽  
Single Dose Administration ◽  
Maximum Steady State

scholarly journals Pharmacokinetics of Telithromycin in Plasma and Soft Tissues after Single-Dose Administration to Healthy Volunteers

2004 ◽  
Vol 48 (12) ◽  
pp. 4650-4653 ◽  
Author(s):  
Rainer Gattringer ◽  
Eleonora Urbauer ◽  
Friederike Traunmüller ◽  
Markus Zeitlinger ◽  
Pejman Dehghanyar ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Single Dose ◽  
Healthy Volunteers ◽  
Streptococcus Pyogenes ◽  
Soft Tissues ◽  
Time Curve ◽  
Dose Administration ◽  
Single Dose Administration

ABSTRACT By use of microdialysis we assessed the concentrations of telithromycin in muscle and adipose tissue to test its ability to penetrate soft tissues. The ratios of the area under the concentration-versus-time curve from 0 to 24 h to the MIC indicated that free concentrations of telithromycin in tissue and plasma might be effective against Streptococcus pyogenes but not against staphylococci and human and animal bite pathogens.

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